某水电设备联合厂房建设项目职业病危害控制效果评价

目的 对某大型水电设备联合厂房建设项目进行职业病危害控制效果评价，确定该项目建成投产后的职业病危害因素，分析其危害程度，评价相应防护措施的运行效果。方法采用现场调查法、检测检验法和检查表法相结合的原则进行综合评价。结果该建设项目存在的职业病危害因素为化学性职业病危害因素锰、一氧化碳、臭氧、苯、甲苯、二甲苯、汽油、丙酮、乙酸乙酯、氯氧化物、甲醛等；粉尘有电焊尘、金属尘、玻璃棉尘、其他类粉尘等；物理性职业病危害因素有噪声、紫外线等。结论项目对《职业病危害预评价报告书》和在设计阶段卫生行政部门提出应采取的职业病危害控制措施要求，在建设中逐条与建设项目进行同步配套建设，基本落实了各项职业病防护设施，怛所有作业区同处一联合厂房的设计存在缺陷，职业卫生管理措施还需完善．     

大姚县青石棉污染区主要恶性肿瘤的健康生命损失年分析

目的评价云南省大姚县环境青石棉污染对人群健康及社会造成的危害。方法通过查阅当地县级医院门诊和住院登记恶性肿瘤病例、人口死因登记报告中1994至2003年期间死亡的恶性肿瘤患者。用健康生命损失年评价当地恶性肿瘤引起的死亡、健康寿命损失及社会负担。结果1994至2003年，青石棉污染区肺癌、肝癌、间皮瘤、胃癌、结肠直肠癌的死亡率分别为10．15／10万、9．04／10万、8．48／10万、3．96／10万、3．55／10万。除女性乳腺癌外，男女各主要恶性肿瘤死亡率均随年龄增长而增长。肝癌、肺癌、问皮瘤、白血病、胃癌的健康生命损失年损失分别是1981．39、1886．63、1799．23、948．01、754．18人年。健康生命损失年损失的年龄分布主要集中于15～44岁和45～59岁年龄组。恶性肿瘤引起的间接经济损失以肺癌、肝癌、间皮瘤造成的损失较大，分别占总损失的15．02％、13．98％、13．01％。青石棉污染引起的健康生命损失年为3092．23人年，间接经济损失517．58万元。结论肺癌、肝癌、间皮瘤、白血病和女性乳腺癌对污染区人群健康和社会危害影响较大。恶性肿瘤造成的中老年人死亡较为严重，引起的青壮年死亡造成的社会损失最大。     

两种膨润土细胞毒性的体外试验研究

Objective To study comparatively the cytotoxicity induced by acid bentonite and organic bentonite.Methods The cytotoxicity of two kinds of bentonite was detected using CCK8 assay,neutral red uptake(NRU) assay,lactate dehydrogenase(LDH) leakage assay,apoptosis assay and hemolysis assay.In hemolysis assay human erythrocytes served as target cells and were exposed to the two kinds of bentonite at the doses of 0,0.3125,0.6250,1.2500 and 2.5000 mg/ml for ten min.In other four assays,human B lymphoblast cells (HMy2.CIR) served as target cells and were exposed to the two kinds of bentonite at the doses of 0,10,20,30,60,120 and 180 μg/ml for four h.Results In hemolysis assay,the hemolysis rates induced by two kinds of bentonite at all doses were significantly higher than that of control (P＜0.05);in CCK-8 assay,the cellular activities in acid bentonite group at the doses ≥30 μg/ml and in organic bentonite group at the doses ≥20μg/ml were significantly lower than that of control (P＜0.01);the similar results appeared in NRU assay and LDH assay,and the dose-effect relationship was observed in above 4 assays.In apeptosis assay,the early apoptosis cell rates in acid bentonite group at the dose of 180 μg/ml and in organic bentonite group at the doses of 120,180 μg/ml were significantly higher than that of control (P＜0.05).Moreover,the results of five in vitro assays indicated the eytotoxicity induced by organic bentonite was higher than that induced by acid bentonite.Conclusion Two kinds of bentonite could induce cytotoxicity,such as apoptosis and damage of cell membrane.The cytotoxicity of organic bentonite is higher than that of acid bentonite due to the different industrial treatment and characteristics of two kinds of bentonite particles.     

利巴韦林凝胶滴眼剂的制备与含量测定

<正>利巴韦林(Ribavirin)为单磷酸次黄嘌呤核苷(IMP)脱氢酶抑制剂,具有广谱抗病毒作用,局部用药适用于单纯疱疹病毒性角膜炎,疗效确切。但普通滴眼液药效维持时间短,生物利用度低。眼用亲水凝胶能延长药物在角膜前滞留和接触时间,而药物从凝胶中逐渐限量溶出,则具有一定缓释效果。     

HPLC法测定常通舒颗粒中芍药苷的含量

<正>常通舒颗粒为卫生部药品标准中药成方制剂第十册收载的品种,原标准中仅有白芍的TLC鉴别。为提高该品的质控标准,以更好的控制药物的内在质量,笔者采用HPLC法对方中白芍进行了含量测定。现报告如下。     

阻塞性睡眠呼吸暂停低通气综合征与儿童生长发育

阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OS-AHS)是儿童常见疾病之一,直接关系到儿童体格、认知发育及心理健康,已逐渐受到重视。本文就近年来关于此病对儿童生长发育影响的研究做一综述。     

阻塞性睡眠呼吸暂停低通气综合征与儿童生长发育

阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome,OS-AHS）是儿童常见疾病之一,直接关系到儿童体格、认知发育及心理健康,已逐渐受到重视。本文就近年来关于此病对儿童生长发育影响的研究做一综述。     

吡哌酸片溶出度光纤传感实时分析研究

 目的建立吡哌酸片剂溶出度的光纤传感实时检测方法。方法采用转篮法,转速100r·min^-1,以稀盐酸(24→1000)为溶出介质,用光纤化学传感药物溶出度实时分析系统在320nm处检测紫外吸收。同时用药典规定方法检测溶出浓度,以作相互对照。结果在50.～249μg·mL^-1内,吸光度与吡哌酸片的浓度成线性关系,平均回收率为100.4%。光纤传感实时检测方法所得结果与药典方法结果无显著性差异(P>0.05)。结论所建立的吡哌酸片剂溶出度的光纤传感实时检测方法可行,在位在线、连续定量地反映了药物体外溶出特性。     

两种膨润土细胞毒性的体外试验研究

Objective To study comparatively the cytotoxicity induced by acid bentonite and organic bentonite.Methods The cytotoxicity of two kinds of bentonite was detected using CCK8 assay,neutral red uptake(NRU) assay,lactate dehydrogenase(LDH) leakage assay,apoptosis assay and hemolysis assay.In hemolysis assay human erythrocytes served as target cells and were exposed to the two kinds of bentonite at the doses of 0,0.3125,0.6250,1.2500 and 2.5000 mg/ml for ten min.In other four assays,human B lymphoblast cells (HMy2.CIR) served as target cells and were exposed to the two kinds of bentonite at the doses of 0,10,20,30,60,120 and 180 μg/ml for four h.Results In hemolysis assay,the hemolysis rates induced by two kinds of bentonite at all doses were significantly higher than that of control (P＜0.05);in CCK-8 assay,the cellular activities in acid bentonite group at the doses ≥30 μg/ml and in organic bentonite group at the doses ≥20μg/ml were significantly lower than that of control (P＜0.01);the similar results appeared in NRU assay and LDH assay,and the dose-effect relationship was observed in above 4 assays.In apeptosis assay,the early apoptosis cell rates in acid bentonite group at the dose of 180 μg/ml and in organic bentonite group at the doses of 120,180 μg/ml were significantly higher than that of control (P＜0.05).Moreover,the results of five in vitro assays indicated the eytotoxicity induced by organic bentonite was higher than that induced by acid bentonite.Conclusion Two kinds of bentonite could induce cytotoxicity,such as apoptosis and damage of cell membrane.The cytotoxicity of organic bentonite is higher than that of acid bentonite due to the different industrial treatment and characteristics of two kinds of bentonite particles.     

自制复方甲硝唑痤疮擦剂治疗痤疮50例

痤疮是青少年人的多发病、常见病。人群中约有80％-90％的人患过此病。它不仅影响人的容貌美，而且带来精神和肉体上的痛苦。目前，治疗方法各异，疗效不甚显著。我院自2001-2005年，采用自制复方甲硝唑擦剂治疗痤疮50例，取得满意的效果，现报告如下。