皮肤淋巴瘤的新分类

恶性淋巴瘤（ｍａｌｉｇｎａｎｔｌｙｍｐｈｏｍａ,ＭＬ）是指来源于淋巴细胞的恶性肿瘤,由于到目前为止,人们认为没有淋巴细胞发生的良性肿瘤,故逐渐将“恶性”两字省略而简称淋巴瘤。１　淋巴瘤需要分类淋巴瘤与人体其它组织的恶性肿瘤相比,最显著的特点是其多样性（ｍｕｌｔｉｐｌｉｃｉｔｙ）或称为异质性（ｈｅｔｅｒｏｇｅｎｅｉｔｙ）,主要表现为：（１）淋巴组织分布广泛,淋巴瘤也呈全身性疾病。除主要见于淋巴结外,还可见于全身各器官和／或组织,也就决定了临床准确分期的重要性;（２）淋巴细胞种类多样,淋巴瘤的类型也…     

对王琳等报告1例原发性皮肤中心母细胞淋巴瘤的命名和分类的探讨

顷读<临床皮肤科杂志>1999年8月第28卷第4期251～252页刊登王琳等报告1例原发性皮肤中心母细胞淋巴瘤,兹对其命名和分类探讨如下.     

细胞毒T细胞识别皮肤T细胞淋巴瘤的T细胞受体个体基型肽抗原

目的 确定细胞毒Ｔ细胞是否能识别由第三互补决定区特异基因编码的肽。方法 选择两例皮肤Ｔ细胞淋巴瘤（ＣＴＣＬ）患者（ＳＳ和ＡＲ）和ＣＤ４＾＋、Ｖβ８＾＋恶性Ｔ细胞作为测定肽序列的细胞,ＣＤ８＾＋非恶性Ｔ细胞作为杀伤或反应性细胞,和转化的淋巴母细胞样细胞作为主要组织相容性复合体（ＭＨＣ）抗原提呈的细胞。结果 患者ＳＳ的恶性Ｔ细胞受体（ＴＣＲ）β链的个体基因型肽可刺激ＣＤ８＾＋Ｔ细胞产生肿瘤坏死因子（Ｔ     

STUDY OF 310 CASES OF BEHCET''S SYNDROME

This article reports 310 cases of BeheeCs syn- drome seen from 1958-1981 in the Dermatology Department, now the Institute of Dermatology, Shanghai First Medical College. The syndrome is considered to be a multi-systemic disease af- fecting 4 chief areas: the oral cavity (99.070), skin (96.8To), external genitalia (73.6To) and eyes (39.4To). In this series, joints are involved in 189 {60.9%) among which 15'7 (83.1%) have knee joint involvement. Therefore, the joint may also be included in the chief affected areas. Other sys- tems such as the cardiovascular, gastrointestinal and neurologic systems or other organs are less commonly affected. In the 310, a group of 26 in which the 3-4 chief areas are simultaneously or successively affected within 3 months accom- panied by more severe general condition, is con- sidered the acute type while the relst, with areas affected in 6 months t0 21 years with milder symptoms, are chronic type. Both types run a chronic course with a tendency to ameliorate after 14 years and chiefly involves simultaneous or successive attacks on 3-4 chief areas, repeated recurrence, and chronic course. Characteristics of erytheinatous halo around the nodules, folli- culitis-like lesions, atrophy of tongue tip fungi- form papillae and positive needle puncture phe- nomenon are helpful in diagnosing the disease. Laboratory findings reveal increased ESR, mucoprotein and ceruloplasmin in the majority with some positive cryoglobulin determinations. Immunologic examinations show decreased cel- lular immunity. Hemorrheologic determination and microcirculation of nail fold and tongue tip show increased microcirculatory blood viscosity. Histopathologic examination of nodular skin le- sions show that the disease process is located mainly in the connective tissue of interlobular septa of subcutaneous tissue and primary vas- culitis of arterioles, venules and capillaries of the middle and lower dermis with abscess-like formation. The etiology remains obscure.     

皮肤恶性淋巴瘤的分类

本研究对上海医科大学皮肤病学研究所26年(1954年—1965年和1972年—1987年)间经长期临床随访和病理组织学检查(包括多种新技术)确诊的204例皮肤恶性淋巴瘤进行了综合分析,提供具有一定代表性的我国皮肤恶性淋巴瘤资料和分类。主要发现如下:     

皮肤恶性淋巴瘤新的分类研究

皮肤恶性淋巴瘤 (cutaneous malignant lym-phomas,CML)是一组极为异质性的疾病 ,其各个病种和亚型的瘤细胞来源、形态学、免疫表型、分子遗传学和生物学行为的特点以及临床表现和病程与治疗的效应均不同 .因此 ,探寻适合临床应用的 CML新分类 ,对诊治恶性淋巴瘤 (malignant lymphoms,ML )至关重要。已成为世界各国学者普遍接受并统一使用的非霍奇金淋巴瘤 (non- Hodgkin' s lymphomas,NHL)分类方案 ,主要根据 1 982年公布的工作规范(working formulation,WF)和 1 988年修订的 Kiel分类。该方案根据淋巴结 ML的细胞学分级 ,常与临床…     

WHO肿瘤新分类——皮肤肿瘤组织学类型(二)

３．２．１．２乳头状汗腺瘤Ｈｉｄｒａｄｅｎｏｍａｐａｐｉｌｉｆｅｒｕｍ３．２．１．３乳头状汗管囊腺瘤Ｓｙｒｉｎｇｏｃｙｓｔａｄｅｎｏｍａｐａｐｉｌｉｆｅｒｕｍ３．２．１．４大汗腺腺瘤Ａｐｏｃｒｉｎｅａｄｅｎｏｍａ３．２．１．５圆柱瘤Ｃｙｌｉｎｄｒｏｍ...     

肉芽肿性蕈样肉芽肿

肉芽肿性蕈样肉芽肿是蕈样肉芽肿的一种罕见的组织学变异。复习文献闹述肉芽肿性蕈样肉芽肿的临床表现、组织病理变化、免疫组化染色、发病机制、诊断和鉴别诊断与预后。     

皮肤淋巴瘤 第四讲 皮肤T细胞淋巴瘤向大细胞淋巴瘤转化

阐述皮肤T细胞淋巴瘤向大细胞淋巴瘤转化的临床表现、组织病理、免疫组织化学染色、分子生物学特征、诊断和鉴别诊断与治疗。     

皮肤γδ-T细胞淋巴瘤临床和组织病理特征

皮肤γδ-T细胞淋巴瘤是指瘤细胞起源于γδ-T细胞的一组Epstein-Barr病毒阴性的皮肤外周T细胞淋巴瘤。其病程呈侵袭性，预后差。皮肤损害主要发生于上、下肢，偶或泛发，累及躯干，常表现为蕈样肉芽肿样斑块、皮下结节或溃疡性肿瘤。同一患者常出现一种以上的组织病理模式[向表皮性、侵犯真皮和(或)皮下脂肪组织]。瘤细胞多形提示T细胞受体γ或δ基因重排，表达CD^4-、CD8^-，成熟细胞毒性表型，偶或CD8^ 表型；常伴坏死和(或)细胞凋亡。