克山病病区玉米及酱块对大鼠心肌损伤的实验研究

Objective To investigate the myocardial damage in rats fed with corn from Keshan disease area added with bean puree. Methods Male Wistar rats were randomly divided into 3 groups according to their body weights, and fed with corn, corn from Keshan disease area added with bean puree, corn from non-endemic area. The GSH-Px activity of vena cardalis blood was examined in 1 and 3 months, rats were sacrificed after being fed for 6 months to examine the heart changes with HE stain. Results The three groups of GSH-Px activity were different in 1 and 3 months respectively(F=23.60,72.46, all P<0.01); GSH-Px activity was (181.58±22.15), (44.76±28.59)U/L in rats fed with corn, was (195.03±17.66), (30.38±3.35)U/L in those fed with corn added with bean puree from Keshan disease area, lower than the group fed with corn of non-endemic area[(340.90±95.42), (125.17±13.64)U/L, all P < 0.01]. But the difference of GSH-Px activity between simple corn group and corn adding bean puree groups of Keshan disease area was not obvious(P>0.05). Myocardial damage incidence of the three groups was 3/9,1/9,2/7. Difference among three groups did not have statistical significance(χ2=1.33, P> 0.05). Conclusions Only corn from Keshan disease area may induce myocardial damage pathology change. Adding bean puree into corn does not increase damage.     

酒精性肝病临床诊治策略

目的：探讨酒精性肝病（ ALD）的临床特征及诊治方法。方法选取2012年5月-2013年7月诊治的ALD患者64例,对患者临床资料进行回顾性分析。观察临床疗效和治疗前后γ-谷氨酰基转移酶（ GGT）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平变化。结果64例患者的治疗总有效率为92．2％,GGT、ALT与AST水平均低于治疗前,差异均有统计学意义（ P＜0．05）。结论 ALD损害程度与患者饮酒量之间有密切联系。ALD患者经戒酒、营养支持与保肝治疗后,临床疗效显著,同时应加强健康教育,促使患者不良行为习惯得到纠正。     

大承气汤对危重症患者胃肠功能衰竭防治作用研究

目的：研究大承气汤对危重症患者胃肠功能衰竭的防治作用。方法回顾性分析2011－12～2014－12间本院ICU收治的112例危重症患者的临床资料,按是否发生肠胃功能障碍将其分为预防组与对照组,每组各56例。预防组入院后立即予以大承气汤治疗,对照组均予以生理盐水治疗,对出现肠胃功能障碍者予以大承气汤,分析两组治疗效果。结果预防组胃肠功能障碍发生率低于对照组,胃液pH值高于对照组,且对照组中胃肠功能障碍者治疗后胃肠功能恢复,胃液pH值高于治疗前,比较差异均具统计学意义（ P＜0．05）。结论大承气汤在危重症患者的胃肠功能衰竭防治方面具有积极意义,可有效减少胃肠功能衰竭的发生,平衡患者胃液酸碱度。     

高萍教授治疗食管癌经验

高萍教授长期从事血液肿瘤内科临床的医疗、教学、科研工作,在中西医结合治疗恶性肿瘤及血液系统疾病方面有其独到的见解,积累了丰富的临床经验,取得了较好的临床疗效,尤其在辨证治疗放化疗毒副作用方面有着较深的造诣。笔者有幸随师学习,现将高师治疗食管癌的经验介绍如下。     

高萍教授治疗食管癌经验

高萍教授长期从事血液肿瘤内科临床的医疗、教学、科研工作,在中西医结合治疗恶性肿瘤及血液系统疾病方面有其独到的见解,积累了丰富的临床经验,取得了较好的临床疗效,尤其在辨证治疗放化疗毒副作用方面有着较深的造诣.笔者有幸随师学习,现将高师治疗食管癌的经验介绍如下.     

特殊类型舌下腺囊肿的诊断及治疗

目的：探讨特殊类型舌下腺囊肿的临床特点及诊治原则。方法：回顾19例特殊类型舌下腺囊肿的临床资料并进行随访。结果：19例中哑铃型10例,颌下型9例。主要表现为颌下及舌下区的肿胀。所有病例均行手术治愈。结论：经口内进路将舌下腺切除是最有效的治疗方法。     

正交试验法优选丹参中丹酚酸B的提取工艺

目的优化丹酚酸B提取工艺。方法以提取物的得率及HPLC法测定丹酚酸B含量为指标,考察乙醇浓度、加醇量、提取时间、温度对提取的影响。结果除提取时间外,其它因素对提取物得率的影响均达显著水平,而对其含量的影响以乙醇浓度和温度影响显著。综合最佳提取工艺为70%醇浓度,12倍加液量,于50℃提取1 h。结论以此工艺可获得最佳提取物得率和丹酚酸B含量。     

改良类"V"形切口在下唇缺损修复中的美容效果

下唇近中线缺损小于唇宽的1/3可采用“V”形切口直接拉拢缝合,但术后遗留直线疤痕。我们采用改良类“V”形切口,取得较理想的美容效果,现总结如下:1.手术方法　唇红部仍为矩形切口,下方的皮肤切口设计见图1,由A点向下作弧形切口,切口弧度近似于同侧的颏突外侧沟,止于颏突的一侧     

冠心病患者血压昼夜节律与颈动脉粥样硬化的相关性分析

颈动脉粥样硬化与冠心病有共同的病理基础和危险因素，两者常存在明显相关性。24h动态血压提供的血压昼夜节律“非构型者”改变，往往提示心脑血管事件发生较“构型者”严重。本文报道对64例冠心病患者超声检查双侧颈动脉，同时给予动态血压检测。探讨冠心病患者血压昼夜节律与颈动脉粥样硬化的超声分型关系。     

克山病病区玉米及酱块对大鼠心肌损伤的实验研究

Objective To investigate the myocardial damage in rats fed with corn from Keshan disease area added with bean puree. Methods Male Wistar rats were randomly divided into 3 groups according to their body weights, and fed with corn, corn from Keshan disease area added with bean puree, corn from non-endemic area. The GSH-Px activity of vena cardalis blood was examined in 1 and 3 months, rats were sacrificed after being fed for 6 months to examine the heart changes with HE stain. Results The three groups of GSH-Px activity were different in 1 and 3 months respectively(F=23.60,72.46, all P<0.01); GSH-Px activity was (181.58±22.15), (44.76±28.59)U/L in rats fed with corn, was (195.03±17.66), (30.38±3.35)U/L in those fed with corn added with bean puree from Keshan disease area, lower than the group fed with corn of non-endemic area[(340.90±95.42), (125.17±13.64)U/L, all P < 0.01]. But the difference of GSH-Px activity between simple corn group and corn adding bean puree groups of Keshan disease area was not obvious(P>0.05). Myocardial damage incidence of the three groups was 3/9,1/9,2/7. Difference among three groups did not have statistical significance(χ2=1.33, P> 0.05). Conclusions Only corn from Keshan disease area may induce myocardial damage pathology change. Adding bean puree into corn does not increase damage.