气管恶性淋巴瘤一例

患者女,41岁。渐进加重性呼吸困难1年。2004年初,患者“感冒”后出现咽部异物感,无发热、咳嗽及呼吸困难,服抗炎药,症状无缓解。近2个月症状加重伴气急。外院颈胸部CT示:中段气管肿瘤。遂来我院就诊。体检无异常,电子鼻咽镜检查未见异常。CT扫描:胸上段气管环形增厚,最厚处约1.     

BIOEQUIVALENCE BETWEEN rhGH FOR RECONSTITUTION AND READY-TO-USE rhGH IN TWO LIQUID FORMULATIONS

Objective To evaluate the bioequivalence between recombinant human growth hormone （rhGH） for reconstitution, and two dosages of liquid formulation of rhGH [ （151U） 5mg or （301U） lOmg per 3ml ]. Methods The study drugs were tested in a randomized, single-blind and three-period crossover studies in 24 healthy male subjects. The three drugs were administered by subcutaneous injection at a dose of O. 21U/kg body weight. A continuous somatostatin infusion was given in order to suppress the secretion of endogenous GH. The ve- nous blood samples were drawn at different time points to test the serum concentration of GH. The pharmacokinetic parameters were analyzed by statistical methods. Results 90% confidence intervals （CI） of AUC0-24h among three products were all within 80% - 125% interval （ 103. 4% - 116. 5%, 105. 7% - 119. 6% and 91.9% - 103. 7%, respectively）, and the Cls of C,~ among three products were all within 70% - 143% interval （91.9% - 114. 0%, 103. 7% -127. 2% and 81.6% -97. 4%, respectively）. There was no statisitical difference of tmax among all the three products. Conclusion These data demonstrate that there is bioequivalence between rhGH for reconstitution and two liquid formulations of rhGH.     

复方丹参与脑活素联合应用治疗新生儿缺氧缺血性脑病

目的 探讨复方丹参与脑活素联合应用治疗新生儿缺氧缺血性脑病（HIE）的疗效。方法 对我院自2000年1月-2004年12月入院治疗的新生儿缺氧缺血性脑病病例进行临床分析，在常规治疗的基础上加用复方丹参注射液与脑活素注射液联合应用，观察其疗效。结果 显效40例，有效10例，无效2例；无1例并发硬肿症，无死亡病例。讨论 复方丹参注射液与脑活素注射液联合应用治疗新生儿缺氧缺血性脑病（HIE）效果显著，值得推广。     

糖尿病的眼部表现

糖尿病是一组常见的代谢内分泌病，分原发性和继发性两类。前者占绝火多数，有遗传倾向，其基本病理生理为绝对或相对性胰岛素分泌不足所引起的代谢紊乱，包括糖、蛋白质、脂肪、水及电解质等，严重时常导致酸碱平衡失常；其特征为高血糖、尿糖、葡萄糖耐量减低及胰岛素释放试验异常。临床上早期无症状，到症状期才有多食、多饮、多尿、     

血液稀释治疗冠心病的临床研究

本研究采用等容血液稀释治疗冠心病，并与对照组进行随机对照研究。结果表明，血液稀释组总有效率８７．２３％，显效率为４４．６８％，对心电图缺血性ＳＴ－Ｔ改变、改善率达７７．２７％，其临床疗效及心电图疗效明显优于对照组。     

AN EEG STUDY OF 120 EPILEPTIC FAMILIES

To study the epilepsy heredity, routine EEG tracings of 120 epileptic families and 57 normal control families were carried out. The results suggest that epilepsy shows an obvious tendency to be inherited.     

环境致癌物阻断NIH3T3细胞间隙连接通讯与细胞内游离钙离子…

选用环境致癌物芥子气、苯并（ａ）芘（Ｂ（））、４－硝基喹啉－１一氧化物、二甲基亚硝胺、环磷酰胺、雌二醇、四氯化碳，作用于该细胞１２ｈ后，用划痕标记染料示踪技术检测其对该细胞间隙连接通讯功能的阻断作用，同时测定该细胞内的［Ｃａ＾２＋］ｉ的变化，结果表明，环境致癌物阻断细胞ＧＪＩＣ与［Ｃａ＾＋］ｉ变化密切相关。     

云南大理和吉林双辽人蚤狗株鼠疫菌栓形成能力试验

用鼠疫强毒菌株50012号、84003号,2.8×10~9个菌/ml,分别感染双辽人蚤狗株6批334只和大理人蚤狗株5批341只,均未形成菌栓。试验表明这两株人蚤不是鼠疫的有效传播媒介。