中西医预防治疗PSD研究概括

脑卒中后抑郁是脑卒中常见的并发症之一,发病率较高。随着医学技术的发展,人们对脑卒中后抑郁的认识和治疗手段都在不断提高,国内外越来越重视PSD预防治疗,尤其是卒中急性期预防治疗。现就对卒中急性期预防治疗现状进行综述。     

亲水性敷料应用于新生儿蓝光治疗降低医源性皮肤损伤的效果观察

目的 研究亲水性敷料应用于新生儿蓝光治疗降低医源性皮肤损伤的效果。方法 选取收治的80例病理性黄疸患儿，采用随机数字表法分为研究组和对照组各40例。对照组在蓝光照射时采用常规医用胶贴固定眼罩，研究组采用亲水性敷料贴。对比两组医源性皮肤损伤发生率、不良反应发生率、住院时间、住院费用和家属满意度。结果 研究组医源性皮肤损伤发生率显著低于对照组（P<0.05）；红肿、破溃和皮肤撕脱等不良反应发生率显著低于对照组（P<0.05）；住院时间和住院费用均显著低于对照组（P<0.05）；家属满意度显著高于对照组（P<0.05）。结论 亲水性敷料应用于新生儿蓝光治疗可有效预防出现医源性皮肤损伤，同时降低红肿、破溃和皮肤撕脱等不良反应的发生，缩短住院时间及降低住院费用效果明显，且患儿家属的满意度较高。     

基于结构方程分析老年肺炎患者健康行为的影响因素

目的:观察老年肺炎患者健康行为水平现状,并基于结构方程分析老年肺炎患者健康行为的影响因素.方法:选取本院2019年12月-2020年12月治疗的老年肺炎患者74例作为研究对象.采用健康行为促进生活方式量表(HPLP-C)评估患者健康行为情况,统计患者基线资料,分析老年肺炎患者健康行为水平的影响因素.结果:74例老年肺炎患者HPLP-Ⅱ评分为50-96分,平均(70.12±10.34)分;经多元线性回归分析结果显示,文化程度高中及以下、抑郁、社会支持度低下是老年肺炎患者健康行为水平低的影响因素(P<0.05);建立老年肺炎患者健康水平的结构方程模型,结果显示,文化程度高中及以下、抑郁、社会支持度低下对老年肺炎患者健康行为水平的总效应分别是0.478、-0.424、0.517;模型拟合度检验结果显示,模型拟合度相关指标均符合参考标准,模型和数据完美拟合.结论:文化程度高中及以下、抑郁、社会支持度低下是老年肺炎患者健康行为水平低的影响因素.     

重复经颅磁刺激对产后轻中度抑郁患者脑血流动力学及初级运动区激活的影响

目的 探讨重复经颅磁刺激（rTMS）治疗产后轻中度抑郁患者的效果及对脑血流动力学及初级运动区激活的影响。方法 选取2020年2月—2023年2月深圳市中医院收治的84例产后轻中度抑郁患者，以随机数表法分为对照组和研究组，每组42例。对照组给予抗抑郁药物，研究组在对照组基础上给予rTMS，治疗后8周评价疗效。对比两组抑郁病情、临床疗效、脑血流动力学指标、脑功能初级运动区激活情况、脑神经因子及不良反应。结果 两组治疗前及治疗后4、8周的汉密顿抑郁量表（HAMD）评分比较，结果：(1)不同时间点HAMD评分比较，差异有统计学意义（F=8.013,P=0.000）；(2)两组HAMD评分比较，差异有统计学意义（F=7.429,P=0.000）；(3)两组HAMD评分变化趋势比较，差异有统计学意义（F=7.005,P=0.000）。研究组总有效率高于对照组（P <0.05）。研究组治疗前后的大脑中动脉、大脑前动脉、大脑后动脉血流速度差值均高于对照组（P <0.05）。研究组治疗前后的左、右手握拳对侧初级运动区激活体积差值均高于对照组（P <0.05）。研究组治疗前后的脑源性神经...     

Mechanism of Polygonum capitatum in treatment of Helicobacter Pylori associated gastritis by network pharmacology,microarray data analysis and molecular docking北大核心CSCD

Aim To explore the mechanism of Polygonum capitatum(PC)in the treatment of Helicobacter Pylori associated gastritis(HAG). Methods The databases were used to identify the target of PC active compounds and HAG-related genes,and the intersection was taken to obtain the potential targets of PC treatment of HAG. The interaction network diagram of “drug-active compound-target-disease” and the protein-protein interaction(PPI)network of potential target protein interaction in HAG treated by PC were constructed by software Cytoscape 3.6.0. The important nodes in the network were screened by several topological indexes,and the GO and KEGG enrichment were analyzed by STRING database to obtain the potential signaling pathway of PC in the treatment of HAG. The binding ability of PC active components with key target proteins was observed by molecular docking method. On this basis,the related targets of PC in the treatment of HAG were verified in vivo and in vitro experiments. Results The PC active compounds and targets were identified through the database,and the “drug-active compound-target-disease” network diagram and the PPI network of potential target proteins were constructed. Combined with several topological indexes,the PPI network of potential target-protein interaction was analyzed,and 52 hub genes were screened. Further bioinformatics analysis and high-throughput sequencing revealed that PC exerted an effect on HAG through the Akt/NF-κB/NLRP3 pathway. Based on this,it was found that PC could reduce IL-18 and IL-1β in HAG GES-1 cells and HAG SD rats,up-regulate Akt and its phosphorylation level and reduce NF-κB expression,inhibit the activation of NLRP3 inflammatory body,so as to improve HAG inflammatory response. Conclusions PC could exert a therapeutic effect on HAG by activating Akt and its phosphorylation level,and inhibiting the expression of NF-κB and NLRP3 inflammasome related factors. This study provides a theoretical basis for explaining the mechanism of PC in the treatment of HAG. © 2023 Publication Centre of Anhui Medical University. All rights reserved.