耳穴疗法优势病种之优选耳穴分析

为分析耳穴的临床应用以期指导临床实践，选取1979年1月-21306年2月中的955篇有关耳穴疗法期刊文章，统计优势病种及所选耳穴，并将所选穴位与1993年5月颁布实施的《中华人民共和国国家标准耳穴名称与部位》（简称（（BG／T13734—92耳穴名称与部位》）中穴位的主治范围进行对比。结果：发现耳穴疗法的临床应用范围有所扩大，为耳穴疗法优化处方奠定基础。     

肿瘤坏死因子-α和白介素-1β对小鼠腹主动脉炎症反应及内皮P-选择素表达的影响

目的:探讨肿瘤坏死因子-α(TNF-α)和(或)白介素-1β(IL-1β)作用后小鼠腹主动脉的炎症反应及内皮P-选择素的表达.方法:32只小鼠随机平均分为3个实验组(1L-1β组、TNF-α组、TNF-α+IL-1β组)和1个对照组,实验组在小鼠腹主动脉周围无菌注射炎性因子TNF-α和(或)IL-1β(对照组用PBS),4 h后取出腹主动脉行HE染色和内皮P-选择素免疫组化染色,定量分析动脉病理形态学的改变和半定量分析内皮P-选择素表达强度.结果:对照组动脉未见明显的病理改变及内皮P-选择素表达,3个实验组的动脉组织则发生不同程度的急性炎症改变,并以TNF-α+IL-1β组为甚,该组动脉发生的病理改变程度和内皮P-选择素表达的强度与范围明显大于IL-1β组和TNF-α组(P<0.05).结论:联合应用TNF-α和IL-1β诱导的大动脉内皮的炎性病变稳定可靠,可用于急性冠状动脉综合症和相关大动脉内皮炎性病变早期的研究.     

携抗P-选择素单抗靶向微泡在炎症模型微循环中黏附机制及行为方式的研究

Objective To evaluate the adhesion mechanisms and microvascular behaviors of P-selectin targeted microbubbles and isotype control microbubbles.Methods The targeted microbubbles with FITC fluorescence and antibodies of P-selectin (MBp), and the isotype control microbubbles with FITC fluorescence and isotype antibodies(MBiso) were constructed.MBp and MBiso were injected intravenously in random to wild-type mice with TNF-α stimulus.The mechanisms and behaviors of MBp and MBiso in cremasteric venules were assessed by fluorescence microscopy.And then velocity variation of ultrasound microbubbles in microvascular was analyzed by tracking fixed-point technology of image-pro-plus software.Results The retention of microbubbles directly to venular endothelium amounted to (8.4 ± 2.1 )/view in MBp-group,while it was only (0.8 ± 0.8)/view in MBiso-group.Difference was evident between of the two groups( P ＜0.01 ).The numbers of MBp and MBiso attachment to activated leukocytes were (3.6± 0.6)/view and (2.2± 0.8)/view separately.There was no obvious difference between the two groups( P ＞0.05).The variation curves of velocity in MBp and MBiso targeting to venular endothelium were different.The flowing rate decreased gradually in MBp-group,while it decreased rapidly in MBiso-group.Conclusions MBp and MBiso have different behaviors targeting to venular endothelium, MBp could adhere to vascular endothelial efficiently and specifically, these results suggest MBp may be used to assess inflammation of vascular endothelial or other tissue injury effectively.     

Protective effect of metoprolol on the development of alcoholic cardiomyopathy in rats

Background Alcoholic cardiomyopathy(ACM)is a chronic cardiomyopathy characterized by dilation and impaired contraction of one or both ventricles with normal or reduced ventricular wall thickness. For the past few years,many studies have shown that metoprolol can improve cardiac function in patients with ACM. However,the effect of metoprolol on cardiac structure and function in patients with ACM remains unclear. Methods A total of 45 Wistar rats were randomly divided into three groups:drug group(n=14),alcohol group(n=15)and control group(n=16). Rats in drug group and alcohol group were received 10% ethanol drinking and gavaged with 60% ethanol to induce ACM. Oral administration of metoprolol was applied in drug group,while the alcohol group received a placebo. The control group was received water and gavaged with normal saline. Left ventricular end-diastolic dimension(LVEDd),left ventricular ejection fraction(LVEF),fractional shortening(FS)were measured by ultrasound in the fourth month after randomization. And then,the myocardial tissues were analyzed. Results The myocardial histopathology of the alcohol group was consistent with the pathologic changes of ACM,which proved model success. Compared with control group,the LVEDd values were significantly higher in drug and alcohol groups(P0.05),while the LVEF and FS values in drug group and alcohol group were significantly lower. Furthermore,the values of LVEDd were higher in alcohol group,while LVEF and FS were significantly lower than those in drug group. Conclusions Metoprolol alleviates the pathophysiological changes of alcoholic cardiomyopathy.[S Chin J Cardiol 2019;20(2):117-120]     

鼻肠管与鼻胃管喂养在预防有创通气患者中并发呼吸机相关性肺炎的临床观察

目的研究鼻肠管与鼻胃管喂养对有创通气患者中呼吸机相关肺炎（VAP）发生率的影响。方法将进行创通气的40例患者随机分成鼻肠管喂养组和鼻胃管喂养组,观察喂养期间VAP的发生情况。结果鼻肠管喂养组VAP发生率为30%,鼻胃管喂养组为75%,两组比较差异有统计学意义（P〈0.01）。结论鼻肠管喂养有利于减少有创通气患者中VAP的发生。     

标准化护理程序在重症监护室心衰患者病情观察中的应用研究

目的探讨标准化护理程序在重症监护室心衰患者病情观察中的应用效果。方法选取2016年1月到2017年12月期间在我院重症监护室住院治疗的心力衰竭患者120例作为研究研究对象,以对照实验要求为依据,随机将其分为观察组和对照组,每组均设置60例研究对象。对照组患者实施常规护理程序,观察组患者实施标准化护理程序。结果两组患者护理前的舒张压、收缩压水平和心率水平均相当,组间比较差异不存在统计学意义(P0.05);两组患者护理后的舒张压、收缩压水平和心率水平,均较护理前有显著降低,但观察组患者的降低幅度显著大于对照组患者,组间比较差异存在统计学意义(P0.05)。观察组患者的致残率、致死率,均明显低于对照组患者,组间比较差异存在统计学意义(P0.05)。观察组患者的急救反应时间、院内反应时间,均明显短于对照组患者,组间比较差异存在统计学意义(P0.05)。结论标准化护理程序的实施能够有效提高重症监护室心衰患者的病情观察质量,利于保证患者生命体征平稳,从而显著降低患者的致残、致死率,提高患者的急救效果。     

卢德维氏咽峡炎的护理

卢德维氏咽峡炎的护理福建省晋江市医院蔡晶晶卢德维氏咽峡炎是口底。颌下和颈部的一种弥漫性炎症，亦是颌面部最严重的感染之一，可以是化脓性，也可以是腐败坏死性的，后者病情发展迅猛，如不及时处埋，可因舌根水肿压迫会厌或因炎症漫延至颈前而压迫气管，出现呼吸困难...     

平衡膳食能达到减重目的吗?

<正>近年来,我国社会经济快速发展,居民的膳食结构和生活方式发生了重要变化。我国最新的肥胖和代谢综合征(MS)调查结果显示,我国成人超重和肥胖的患病率男性分别为33.7%和13.7%,女性分别为29.2%和10.7%[1]。超重和肥胖人数的剧增,导致营养相关的慢性非传染性疾病患病率明显增加,给社会和个人及其家庭带来沉重的经济负担。正因如此,平衡膳食这个概念也逐渐被人们重视起来。在最新版《中国居民膳食指南(2007)》一书中对     

面中部复合性骨折的护理

面中部复合性骨折的护理晋江市医院蔡晶晶因工伤、交通事故、斗殴等引起口腔颌面部损伤，常损伤软组织和骨组织，并引起不同的全身症状。我院于１９９４年至１９９５年６月治疗６０例，疗效满意，报告于下。一、临床资料６０例中，男５８例、女２例；年龄２０～４０岁。损...     

直肠-尿道瘘治疗体会

我院自 1 982年至今收治直肠 -尿道瘘 1 5例获得成功。今将治疗过程中教训及成功体会较深刻的3例介绍如下。1　临床资料3例中男 2例 ,女 1例 ,年龄 3个月～ 1 8岁 ,病程 3个月～ 1 8年。例 1　 1 992年 4月 ,患儿沈某某 ,男性 ,3岁 ,因1周岁时患细菌性痢疾 ,并发肛旁脓肿致肛瘘未及时治疗时好时发 ,肛瘘外口经久不愈 ,经常有脓性及粪汁伴尿样水性排泄物。在尿道口亦常有粪汁排出。入院后经碘液造影 ,观察到直肠 -尿道中后段有明显管道 ,直肠右侧壁与右侧肛缘旁瘘管有外口。第 1次施行肛瘘切开挂线术 ,尿道用导尿管支撑 ,后尿道段修补缝合术 …