骨髓基质细胞向神经细胞诱导分化的研究进展

骨髓基质细胞，与胚胎干细胞一样具有多向分化潜能，在一定条件诱导下，可以跨谱系分化为成骨细胞、软骨细胞、脂肪细胞、肝脏细胞、神经干细胞，并可生成神经元及神经胶质细胞等，脑内移植骨髓基质细胞能改善帕金森病大鼠模型的旋转和缺血小鼠的功能恢复。骨髓取材方便，骨髓基质细胞体外扩增后，进行基因工程修饰或诱导分化为神经干细胞进行自体移植，不存在免疫排斥反应，是干细胞移植治疗脑损伤和神经退行性变的理想材料，有广阔的应用前景。     

留置三腔气囊导尿管引起尿路感染的预防及护理

三腔气囊导尿管的应用 ,避免了一次性导尿管易脱落及胶布固定的缺点。但其并发症不容忽视 ,尤其是糖尿病病人极易发生尿路感染。现将预防及护理体会总结如下。1　用物必须严格消毒灭菌 ,并按无菌操作进行 ,以防发生交叉感染。2　女病人导尿时 ,如误入阴道 ,应更换导尿管重新插入。3　避免尿道损伤 :①插入导尿管见尿液流出后再插入 4～5ｃｍ。然后注生理盐水 10～ 15ｍｌ于气囊内。对清醒患者应询问有无尿道胀痛 ;前列腺增生患者先从尿道口注入 3～ 5ｍｌ石蜡油 ,并选用尖头气囊导尿管 ,以避免尿道粘膜的损伤 ,从而减少尿道感染的机会。②选…     

颅脑损伤病人下肢深静脉血栓形成的临床护理

目的探讨颅脑损伤病人下肢深静脉血栓（DVT）形成后的临床护理方法。方法通过对14例颅脑损伤并发下肢静脉血栓形成病人采用溶栓、抗凝治疗,配合适当抬高患肢,避免患肢液体输入,加强患肢肿胀、皮温、血运等各方面的观察,掌握正确的临床护理方法。结果本组14例病人治疗3周,1例并发肺栓塞,临床死亡,其余病人临床症状好转。结论颅脑损伤并发下肢静脉血栓形成病人,正确的临床护理措施,可以减少致命并发症的出现,加快临床恢复。     

口腔修复技师的职业危害及防护

<正>随着口腔修复学技术的发展,口腔技师在工作中劳动强度加大,劳动环境复杂,接触很多有害物质、受到物理、化学和生物因素的危害,但长期以来,未能引起足够重视,这就要求口腔技师在日常工作过程中,要自觉做到用不同方式保护自己,采取全面预防性防护措施,增强自我防护意识。本文针对口腔修复技师的职业危害及防护进行探讨。     

高脂喂养大鼠内脏脂肪组织C反应蛋白的表达

The abdominal visceral fat content in obese SD rats induced by high fat diet for 10 weeks was significantly higher than that in control group [(26±6 vs 13±3)g,P<0.01] ,along with increased CRP mRNA expression in abdominal visceral fat (0.901±0.085 vs O. 402±0.036, P<0.01). As compared with normal control group, in the high fat group the concentrations of CRP in portal vein [(743.8±95.8 vs 558.3 ±118.3) mg/L, P<0.01] and peripheral vein[(596.3±38.9 vs 485.8±30.2) mg/L,P<0. 05] were higher. The concentration of CRP in portal vein was significantly higher than that in peripheral vein in high fat diet group(P<0.01) ,but this was not evident in control group. These results suggest that the increased CRP expression in visceral adipose tissue may partially account for the elevation of serum CRP in obesity.     

高脂喂养大鼠内脏脂肪组织C反应蛋白的表达

The abdominal visceral fat content in obese SD rats induced by high fat diet for 10 weeks was significantly higher than that in control group [(26±6 vs 13±3)g,P<0.01] ,along with increased CRP mRNA expression in abdominal visceral fat (0.901±0.085 vs O. 402±0.036, P<0.01). As compared with normal control group, in the high fat group the concentrations of CRP in portal vein [(743.8±95.8 vs 558.3 ±118.3) mg/L, P<0.01] and peripheral vein[(596.3±38.9 vs 485.8±30.2) mg/L,P<0. 05] were higher. The concentration of CRP in portal vein was significantly higher than that in peripheral vein in high fat diet group(P<0.01) ,but this was not evident in control group. These results suggest that the increased CRP expression in visceral adipose tissue may partially account for the elevation of serum CRP in obesity.     

Graves病及正常甲状腺组织褪黑素受体亚型表达差异的研究

用RT-PCR半定量分析结果显示,Graves病甲状腺组织及甲状腺腺瘤瘤旁正常甲状腺组织(各5例)均存在褪黑素受体亚型mt1mRNA的表达,未检测到MT2亚型。手术时经药物控制甲状腺功能已正常的Graves病与甲状腺机能仍亢进的Graves病甲状腺组织mt1表达量无差异(P>0.05);Graves病甲状腺组织mt1表达量较正常甲状腺组织明显增加(P<0.01)。提示褪黑素的免疫调节作用可能通过mt1介导,Graves病发病可能与mt1亚型激活有关。     

高脂喂养大鼠内脏脂肪组织C反应蛋白的表达

The abdominal visceral fat content in obese SD rats induced by high fat diet for 10 weeks was significantly higher than that in control group [(26±6 vs 13±3)g,P<0.01] ,along with increased CRP mRNA expression in abdominal visceral fat (0.901±0.085 vs O. 402±0.036, P<0.01). As compared with normal control group, in the high fat group the concentrations of CRP in portal vein [(743.8±95.8 vs 558.3 ±118.3) mg/L, P<0.01] and peripheral vein[(596.3±38.9 vs 485.8±30.2) mg/L,P<0. 05] were higher. The concentration of CRP in portal vein was significantly higher than that in peripheral vein in high fat diet group(P<0.01) ,but this was not evident in control group. These results suggest that the increased CRP expression in visceral adipose tissue may partially account for the elevation of serum CRP in obesity.     

前列地尔注射液对短暂性脑缺血发作脑血流变化的影响

目的探讨前列地尔注射液对短暂性脑缺血发作(TIA)脑血流变化的影响。方法 收集TIA患者121例,随机分为2组,加用前列地尔注射液(治疗组)61例与未加用前列地尔注射液(对照组)60例,治疗前后采用经颅多普勒超声(TCD)检测并对比分析大脑中动脉(MCA)、大脑前动脉(ACA)、双侧椎动脉(VA)及基底动脉(BA)平均血流速度(Vm)的改善,并观察临床疗效。结果 治疗组治愈率、总有效率分别为72.13%、98.36%,明显优于对照组的36.67%、90.00%,差异有统计学意义(P<0.05)。2组治疗前MCA、ACA、VA、BA血流速度比较差异均无统计学意义(P>0.05);治疗后均较治疗前提高(P<0.05,P<0.01),且观察组较对照组提高更显著(P<0.05)。对照组治疗后颈总动脉内径、血流速度、斑块面积无显著改善,治疗组治疗后颈总动脉内径、血流速度显著改善且均优于对照组(P<0.05),而斑块面积亦无显著改善。结论 前列地尔注射液可显著提高TIA患者MCA、ACA、VA、BA血液流速及临床疗效。     

彩超筛查684例甲状腺结节结果讨论

目的:根据采集2012年7月至10月在我院体检的1013例健康人群的甲状腺彩色超声检查结果,发现患有甲状腺结节者684例,分析讨论甲状腺结节在健康人群中患病情况。方法:对1013例健康体检人员进行甲状腺彩色多普勒高频超声检查。结果:1013例健康体检者甲状腺结节阳性率67.52%,其中男性293例,女性391例。结论:甲状腺结节在健康人群中的发病率较高,女性阳性率明显高于男性,且甲状腺结节阳性率随年龄增长有逐年上升趋势。检出的结节多数为良性增生结节,以多发结节为主,占60.96%,恶性或可疑恶性结节占0.11%。