右美托咪定不同给药方式对老年结直肠癌患者术后围术期指标的影响

目的 探究并分析右美托咪定不同给药方式联合腹横肌平面阻滞(transversus abdominis plane,TAP)对老年结直肠癌根治术患者术后苏醒以及免疫功能的影响.方法 选取2018年6月-2019年6月杭州市富阳区第一人民医院收治的95例老年结直肠癌根治术患者,按照随机数字表法将其分为观察组(48例)和对照...     

某二级医院130例护理不良事件与差错分析及防范对策

不良事件是指与医疗护理相关的损伤,差错是指医疗过程中的任何错误,无论是否造成伤害[1]. 本研究分析某二级医院2007年1月-2008年12月上报的护理不良事件与差错130起,并提出防范措施.     

脱细胞尿道细胞外基质修复尿道缺损的临床研究

目的 总结新型替代材料修复尿道缺损的临床经验.方法 采用组织工程学材料脱细胞尿道细胞外基质(ECM)修复男性长段尿道缺损8例.患者平均年龄56岁.病程3～60个月,平均16.7个月.其中陈旧性前尿道狭窄4例、球部尿道狭窄2例、狭窄段从前尿道延伸到后尿道2例.狭窄长度3～8 cm,平均5 cm.结果 8例随访3～21个月,平均12.5个月.术后6周拔除尿管2例,8周拔管6例.无狭窄、尿瘘,排尿通畅7例,1例排尿不畅者定期行尿道扩张.术后8周尿道造影显示尿道通畅,未见吻合口狭窄.结论 脱细胞尿道细胞外基质为机体提供了良好的供宿主组织爬行替代的框架,在修补后可有效地与宿主组织融合,修补后的尿道愈合良好.     

脑血管意外后遗症患者的家庭护理

脑血管意外是神经内科常见的脑血管病，常威胁中老年人的健康和生命，尤其急性脑血管病起病急，病情发展快，病死率和致残率高。患者急性期经过及时合理的抢救和治疗而度过险关后，大部分患者留有不同程度的后遗症如偏瘫、失语及精神、神经功能障碍等，生活多不能完全自理，但又不宜长期住院治疗，因此就必须由患者家属来承担护理工作，其家庭护理要点如下：一、创造卫生、整洁和舒适的环境：住房应保持室内整洁、空气流通、光线充足而柔和，但避免通风过度，以免受凉感冒。二、进行心理护理：脑血管病患者由于肢体功能或精神障碍，生活不能…     

丹曲林钠的HPLC测定

丹曲林钠 (dantrolene sodium,1 )是一种骨骼肌松弛剂[1] ,已在美国和欧洲多个国家上市 ,日本药局方十三版 (1 999年 )收载 ,系采用电位滴定法测定含量 ,操作简单 ,但专属性不强。本文采用 HPLC法测定 1含量 ,结果准确 ,重现性好 ,而且可用于其杂质成分的监测。1　仪器与试药美国 SSI高效液相色谱仪 ,包括 P-4 0 0 0型泵 ,American Hi-Tech 5 0 6型 UV/Vis检测器 ,Ezchrom工作站 ;Sharp PC-15 0 0型计算机。乙腈 (色谱纯 ,美国 Tedia公司 ) ;甲醇 (色谱纯 ,天津四友 ) ;水(重蒸馏水 ) ;丙酮缩氨脲、对硝基苯胺、3-硝基苯基呋喃甲醛…     

用二维电离室阵列对螺旋断层治疗的调强计划进行剂量验证

Objective To investigate the feasibility of dose verification of intensity modulated (IM) planning of helical tomotherapy (HT) using two-dimensional ion chamber array (2DICA),and develop an efficient way to validate the dose delivered under the parameters mirroring those during the treatment. Meth-ods A 2DICA,I'mRT MatriXX and MULTICube equivalent solid water phantom from IBA company were used to verify the dose distribution of 10 IM planning. The combined phantom was set up to measure the dose distributions on coronal and sagittal surface. The precise setup of phantom was guided by HTMVCT images. After the irradiation, the measured dose distributions on the coronal and sngittal plane were compared with those calculated by the IM planning system for verification. The results were evaluated and the feasibility of the different measuring methods was studied. Results The dose distribution measured by the MatriXX 2DICA was well consistent with that calculated by the treatment planning system. The errors between the measured dose and predicted dose in the selected points were within ±3%. In the comparison of the pixel-segmented ionization chamber versus treatment planning system using the 3 mm/3% γ criteria, the passing ratio of pixels with γ parameter ≤1 was 97.76% and 96.83%, respectively. Conclusions MatriXX is a-ble to measure the absolute and relative dose distributions simultaneously,which can be used for dose verifi-cation of IM planning.     

月经过少的超声诊断相关因素

目的调查月经过少的相关因素,进一步探讨月经过少的超声表现。方法纳入月经过少患者53例,同期监测排卵健康育龄女性46例。采用最大似然估计对排卵当日各项超声指数进行Logistic逐步回归分析,筛选出月经过少的主要相关因素。对回归参数估计值采用Waldχ~2检验,对整个模型的拟合情况采用似然比检验,并用ROC曲线法评价Logistic回归模型的预报能力。结果月经过少与子宫内膜下血管数（OR=0.06,95%CI 0.01～0.35）、子宫内膜血流分型（OR=0.15,95%CI 0.02～0.90）、Salle评分（OR=0.19,95%CI 0.05～0.72）等因素相关。建立回归模型能很好地区分月经过少患者及正常人。结论月经过少可能与子宫内膜血流缺乏有关;多数月经过少患者存在子宫内膜容受性低下,为潜在的不孕症患者。     

板蓝根滴丸的稳定性考察

目的考察板蓝根滴丸的稳定性.方法用高效液相色谱（HPLC）法测定板蓝根滴丸中腺苷含量,并考察其他指标.结果板蓝根滴丸样品在加速实验及长期实验中,考察前后各项检查指标均无明显变化,符合药品质量标准的各项规定.结论板蓝根滴丸在室温条件下稳定性较好.     

高效液相色谱法测定呋喃唑酮的含量及其杂质的控制

呋喃唑酮属硝基呋喃类抗菌药,虽然近年其应用呈下降趋势,但因价格低廉,疗效确切,仍有很大的市场,其含量的测定方法为紫外分光光度法,但由于呋喃唑酮在合成过程中的杂质(主要为硝基呋喃甲醛二乙酯,下称二乙酯)在367nm处有很强的吸收,因此很难反映呋喃唑酮的真实含量。我们采用高效液相色谱法,将呋喃唑酮与杂质分离,方法准确,结果可靠。1　仪器、试药与色谱条件SSI高效液相色谱仪(包括P-4000型泵,506紫外检测器,Ezchrom工作站)。呋喃唑酮对照品,二乙酯对照品,呋喃唑酮原料药均由山东金泰集团金达药化有限公司提供,甲醇为色谱纯,磷酸二氢钾为…     

用二维电离室阵列对螺旋断层治疗的调强计划进行剂量验证

Objective To investigate the feasibility of dose verification of intensity modulated (IM) planning of helical tomotherapy (HT) using two-dimensional ion chamber array (2DICA),and develop an efficient way to validate the dose delivered under the parameters mirroring those during the treatment. Meth-ods A 2DICA,I'mRT MatriXX and MULTICube equivalent solid water phantom from IBA company were used to verify the dose distribution of 10 IM planning. The combined phantom was set up to measure the dose distributions on coronal and sagittal surface. The precise setup of phantom was guided by HTMVCT images. After the irradiation, the measured dose distributions on the coronal and sngittal plane were compared with those calculated by the IM planning system for verification. The results were evaluated and the feasibility of the different measuring methods was studied. Results The dose distribution measured by the MatriXX 2DICA was well consistent with that calculated by the treatment planning system. The errors between the measured dose and predicted dose in the selected points were within ±3%. In the comparison of the pixel-segmented ionization chamber versus treatment planning system using the 3 mm/3% γ criteria, the passing ratio of pixels with γ parameter ≤1 was 97.76% and 96.83%, respectively. Conclusions MatriXX is a-ble to measure the absolute and relative dose distributions simultaneously,which can be used for dose verifi-cation of IM planning.