男性胆囊胆固醇结石与胰岛素抵抗和血浆脂联素水平的相关性研究

目的探讨男性胆囊胆固醇结石患者与胰岛素抵抗及血浆脂联素水平的关系。方法检测30例男性胆囊胆固醇结石患者(结石组)与30例健康志愿(对照组)者其血浆脂联素、空腹胰岛素(FINS)、空腹血糖水平,同时监测血压、腰围、体质指数(BMI)、腰臀比并进行比较。结果①结石组血浆脂联素较对照组低(P<0.01),控制BMI、腰围、腰臀比后,结石组脂联素仍较对照组低,差异有统计学意义(P<0.05)。而结石组FINS、胰岛素抵抗指数(HOMA-IR)较对照组高(P<0.01),控制BMI后,FINS、HOMA-IR指数仍较对照组高,差异有统计学意义(P<0.05);但控制腰围、腰臀比后,FINS、HOMA-IR指数较对照组差异无统计学意义(P>0.05)。结石组腰围、腰臀比、BMI较对照组高,差异均有统计学意义(均P<0.01)。②男性胆囊胆固醇结石血浆脂联素与HOMA-IR指数、腰围呈负相关,腰臀比与HOMA-IR指数、FINS呈正相关,均有统计学意义,但脂联素与腰臀比无关。偏相关分析提示控制腰臀比后HOMA-IR指数与脂联素无关(P>0.05)。③多因素分析提示腰臀比、FINS、空腹血糖、脂联素为男性胆囊胆固醇结石发病的危险因素。结论①在未诊断糖尿病、空腹血糖<6.1mmol/L及血脂正常的男性胆囊胆固醇结石患者血浆脂联素水平显著降低,血浆脂联素水平降低是男性胆囊胆固醇结石发病危险因素,患者体脂分布异常在脂联素与胰岛素抵抗之间及脂联素降低可能有一定的作用。②男性胆囊胆固醇结石患者FINS水平升高,且空腹胰岛素水平升高是男性胆囊胆固醇结石患者发病的危险因素。患者FINS水平升高,可能与体脂分布异常有关。③男性胆囊胆固醇结石患者BMI、腰围、腰臀比较对照组高,且腰臀比是男性胆囊胆固醇结石发病的主要危险因素。     

手术取栓治疗急性下肢深静脉血栓形成的系统评价

目的探讨下肢深静脉血拴急性期手术取栓的疗效和安全性。方法计算机检索MEDLINE(1966-2006．6)、EMbase(1984-2006．6)、Cochrane图书馆(2006年第2期)、中国生物医学文献数据库(1989-2006．6)、中文生物医学期刊数据库(1994-2006．6)和中国医学学术会议论文数据库(1994-1999),手枪国内《血管外科会议汇编》(1991-2006．6)和国内《血管外科》杂志(2000-2006．6),纳入手术取栓与标准抗凝治疗比较的随机对照试验。由两名研究者独立进行文献质量评价和数据提取,并按Cochrane协作网提供的方法对纳入文献进行质量评价和结果分析。结果共检索到相关文献8篇,其中6篇符合纳入标准。手术取栓组6个月静脉完全通畅率高于抗凝治疗组[OR=7．26,95％CI(2．40,21．94)]。两组5年静脉通畅率差异无统计学意义[OR=2．59,95%CI(0．88,7．67)]。手术取栓组6个月深静脉血栓形成后综合征(PTS)的发生率[OR=0．11,95％CI(0．59,1．59)]和5年PTS发生率[OR=0．18,95％CI(0．06,0．60)]均低于抗凝组,但两组10年PTS发生率和大部分瓣膜静脉功能测定指标无差异。两组肺栓塞的发生率差异无统计学意义[OR=1．40,95％CI(0.39,4．97)]。结论对于争性下肢深静脉血栓形成患者,手术取栓仅能促进其近期静脉瓣膜功能恢复和通畅程度,而对改善通畅率作用不显著。目前缺乏足够的证据证实手术远期疗效具有优势。手术取栓具有较好的安全性。鉴于本评价纳入的试验样本量小,质量不高,且多数发表年限较早,降低了结论的可靠性,亟需大样本试验证实其疗效。     

医源性股动脉假性动脉瘤的治疗方法

Objective To evaluate the effect on ultrasound-guided locsl comprression and surgical to treat iatrogenic fem- oral artery pseudoanerurysms. Methods 197 patients were diagnosed as iatrogenic femoral artery pseudoaneurysms from Apri 1199 to April 2008.There were 122 male and 75 female, aged 59.7 years (rimed 40- 81 years). One. Hundrel and severty-one stahle cases were managed by ultrasound-guided local compression initially and 26 patients were directly treated with surgical repair because d the rupture of femoral artery pesudoaneurysms or the pseudoaneurysms≥40mm in diameter. Results 171 patients received llocal com- pression therapy, 137 cases were cured directly (the effective rate was 80%), but the last failed 34 cases were required conversion to surgical reparr. The nymber of the surgical repaired patients was 60 (incluing 26 cases with direct operation and 34 cases with required conversion to surgical repair). Forty-seven patients received direct excision of femoral artery pseudoaneurysm, six patients underwent angioplasty with autogenously saphenous vein patch, and seven patients got bypass operation with artificial vascular graft. During the perioperative period, no serious complications including bleeding, neuralgia, and lymphatic fistula even arterio venous fis- tula and so on, no death occurred. All patients were followed up for 1 month to5 years after the procedures, no local FAP recurred, no limb ischemia developed and no deaths occurred. Conclusion Uitrasound-guided compression, surgical repair, and ultrasound- guided percutaneous thrombin injection are the three main modalities of treating iatrogenic FAP, while ultrasound-guided compresson and magical therapy get popularized domestically. Ultrasound-guided comperession seems a safe, inexpensive, and effective method for the managerment of iatrogenic femoral artery pseudoaneurysms. It may be used as a lust-line therapetic modality for mint of the un-complicated patients. However, surgical repair can be reserved for those who failed comperssion therapy or unsuitable as mentioned above.     

不同样品制备方法对血浆双向凝胶电泳图谱的影响

目的探讨不同的样品制备方法对多发性大动脉炎患者血浆蛋白质组的双向凝胶电泳图谱的影响,为鉴定差异表达蛋白提供优化条件。方法采用加入SDS加热法和离心超滤方法制备方法对血浆进行处理,和未经任何处理直接上样,以90μg等上样量进行电泳,电泳方法和常规的100μg银染和1000μg考马斯亮蓝染色方法的双向凝胶电泳的图谱的图像、蛋白点数等进行对比。结果SDS加热法和离心超滤能明显改善图谱中自蛋白高丰度蛋白周围的显示。SDS加热法和离心超滤法90μg银染显示的蛋白点数分别为892.17±162.99,869.50±95.62,695.67±84.11。结论对于多发性大动脉炎血浆采用SDS加热和离心超滤进行血浆样品制备,能明显改善血浆双向凝胶电泳图谱,以90μg血浆上样量的银染方法较为合适。     

连续性血液净化治疗多脏器功能障碍综合征

多脏器功能障碍综合征(MODS)是严重创伤、严重感染、外科大手术、病理产科等原发病发生后,同时或序贯出现两个或两个以上系统器官的功能不全或衰竭的临床综合征,病死率较高.我院近年来采用连续性血液净化(CBP)抢救此类患者11例,现报告如下.     

医源性股动脉假性动脉瘤的治疗方法

Objective To evaluate the effect on ultrasound-guided locsl comprression and surgical to treat iatrogenic fem- oral artery pseudoanerurysms. Methods 197 patients were diagnosed as iatrogenic femoral artery pseudoaneurysms from Apri 1199 to April 2008.There were 122 male and 75 female, aged 59.7 years (rimed 40- 81 years). One. Hundrel and severty-one stahle cases were managed by ultrasound-guided local compression initially and 26 patients were directly treated with surgical repair because d the rupture of femoral artery pesudoaneurysms or the pseudoaneurysms≥40mm in diameter. Results 171 patients received llocal com- pression therapy, 137 cases were cured directly (the effective rate was 80%), but the last failed 34 cases were required conversion to surgical reparr. The nymber of the surgical repaired patients was 60 (incluing 26 cases with direct operation and 34 cases with required conversion to surgical repair). Forty-seven patients received direct excision of femoral artery pseudoaneurysm, six patients underwent angioplasty with autogenously saphenous vein patch, and seven patients got bypass operation with artificial vascular graft. During the perioperative period, no serious complications including bleeding, neuralgia, and lymphatic fistula even arterio venous fis- tula and so on, no death occurred. All patients were followed up for 1 month to5 years after the procedures, no local FAP recurred, no limb ischemia developed and no deaths occurred. Conclusion Uitrasound-guided compression, surgical repair, and ultrasound- guided percutaneous thrombin injection are the three main modalities of treating iatrogenic FAP, while ultrasound-guided compresson and magical therapy get popularized domestically. Ultrasound-guided comperession seems a safe, inexpensive, and effective method for the managerment of iatrogenic femoral artery pseudoaneurysms. It may be used as a lust-line therapetic modality for mint of the un-complicated patients. However, surgical repair can be reserved for those who failed comperssion therapy or unsuitable as mentioned above.     

华法林在我国治疗静脉血栓栓塞性疾病的最优抗凝区间

目的 前瞻性研究我国静脉血栓栓塞性疾病(VTE)患者不同华法林抗凝强度区间的出血率和VTE复发率及寻找最优国际标准化比值(INR)区间.方法 将2006年10月至2007年7月间安贞医院收治的180例VTE患者作为研究对象,随机分成A、B、C 3组,每组各60例,分别对应INR目标区问是1.50～1.99(低强度抗凝组)、2.00～2.50(中等强度抗凝组)及2.51～3.00(高强度抗凝组).INR稳定在目标区间2周以上后,开始正式观察每组大、中、小量出血率及VTE复发率.研究者及观察对象均遵循盲法原则.结果 低强度组与中高强度组的复发率分别为8.3%、1.7%(P=0.042).低、中、高强度抗凝3组间少量出血率分别为8.3%、18.3%及6.7%(P=0.089);低与中高强度组中量出血率分别为3.3%、7.5%(P=0.341);低与中高强度组大量出血率分别为0%、3.3%(P=0.303).62岁以上人群,中低强度组大出血(1例)与高强度组(3例)相比(即INR从1.5～2.5增加到2.51～3.00),危险比为12.600(95%可信区间为1.183～134.238).结论 对于一般中国人.华法林抗凝INR在2.0～3.0之间既能减少VTE复发风险又不增加出血风险,故INR应推荐在2.0～3.0之间.对于年龄62岁以上的高龄人群,INR应推荐在2.0～2.5之间.     

21——羟化酶缺陷——附一例女性假两性畸形病例报告

我院于1981年收治21—羟化酶缺陷、表现为女性假两性畸形患者一例,现报道如下: 患者住院号526242,女性,8岁,因阴蒂肥大要求诊治于81年2月10日入院。患儿于三年前(5岁时)即发现阴蒂肥大,以后逐渐增长,二年来增大更为明显,有时可勃起,性格似男孩,脾气急躁任性、身材粗壮,比同龄儿童高大,嗓音变粗,喉结长大,全身毳毛增多,有阴毛出现.患儿幼时体健,父母健康,其母于妊娠早期未接受过孕酮等激素类药物.其弟体健,无类似情况。     

急性下肢深静脉血栓形成腔内治疗的疗效分析

目的:探讨腔内治疗急性下肢深静脉血栓形成的疗效。方法:分析2009年1月年至2011年5月,采用导管溶栓和支架治疗16例急性下肢深静脉血栓形成的临床资料,采用静脉节段性病变评分和静脉临床程度评分评估手术疗效。结果:16例患者中,中央型静脉血栓14例,混合型下肢深静脉血栓形成2例。合并髂静脉压迫综合征11例。病史中位数为5 d(范围1～14 d)。患者均行静脉导管溶栓,其中12例接受髂静脉支架。随访中位数为6个月(范围1～24个月),术后30 d静脉通畅程度评分平均(1.38±0.90)分,低于术前〔(5.5±2.6)分;P=0.001〕,术前静脉临床程度评分平均(4.69±0.7)分,术后1个月、6个月静脉临床程度评分分别为(1.44±1.27)分、(1.42±0.9)分,低于术前(P=0.001,P<0.01)。术后1个月,6个月髂静脉支架通畅率均为83%。结论:选择性腔内治疗急性下肢深静脉血栓可显著改善患者临床症状,远期疗效有待进一步确定。     

老年住院患者下肢动脉硬化闭塞症与心脑血管疾病的相关性

目的 探讨下肢动脉硬化闭塞症(ASO)与冠心病和脑卒中的相关性。方法 回顾性分析2013年10月至2021年3月在首都医科大学附属北京世纪坛医院血管外科住院的587例老年下肢ASO患者的临床资料。调查住院患者冠心病和脑卒中患病率。分析Fontaine缺血分期、踝肱指数(ABI)与冠心病和脑卒中的相关性。采用SPSS 26.0 统计软件进行数据分析。相关性分析采用Spearman相关分析。结果 587例下肢ASO患者合并冠心病、脑卒中、冠心病和脑卒中患病率分别32.20%(189/587)、13.12%(77/587)及17.21%(101/587)。下肢Fontaine缺血分期与冠心病(r=7.57)及脑卒中(r=3.57)的发生呈正相关(均P<0.01)。Fontaine缺血分期与合并心脑血管疾病种类数呈正相关(r=0.13;P=0.02)。合并冠心病与无冠心病患者[0.30(0.00,0.55)和0.68(0.50,0.80)]、合并脑卒中与无脑卒中患者[0.40(0.15,0.62)和0.60(0.20,0.75)]的ABI数值比较,差异有统计学意义(均P<0.01)。ABI值与合并心脑血管疾病种类数呈负相关性(r=-0.48;P<0.01)。结论 老年下肢动脉硬化闭塞症患者心脑血管疾病发生率高。下肢缺血越重,发生心脑血管疾病风险越高。