76例不稳定性心绞痛患者的临床疗效观察

目的：研究低分子肝素钙在不稳定性心绞痛（uA）中的治疗效果。方法：选择住院UA患者76例,随机分为两组,其中观察组39例,对照组37例,其中观察组在对照组常规抗心绞痛治疗的基础上,另加低分子肝素钙5000IU,皮下注射,1次／12h,连用半月,并比较其疗效。结果：观察组显效28例（71．8％）,有效10例（25．6％）,无效1例（2．56）,总有效率97．44％;对照组显效20例（54．1％）,有效11例（29．7％）,无效6例（16．2％）,总有效率83．8％与观察组比较,两组疗效差异有统计学意义（P〈0．05）。观察组没有发生猝死和急性心肌梗死的病例;但对照组猝死2例,发生急性心肌梗死3例,心脏事件的发生率13．5％,与治疗组比较,差异有统计学意义（P〈0．05）。可见观察组治疗安全有效,值得临床推广应用。     

心力衰竭使心脏猝死的防治对策研究

目的：探讨终末期心力衰竭时心脏性猝死的防治措施。方法：分析药物、埋藏式心脏复律除颤器（ICD）以及心脏再同步治疗及心律转复除颤系统（CRT—D）对预防终末期心力衰竭时心脏性猝死。结果：药物是心力衰竭引发猝死的防治基础;ICD可用于缺血性心肌病或非缺血性心肌病心力衰竭病人心脏性猝死的一级以及二级预防;CRT—D也可降低猝死的发生率。结论：药物、ICD和CRT—D能有效地预防和治疗心力衰竭所导致的猝死。     

全髋关节置换扩大后路软组织修补关节囊切开线的解剖学研究

OBJECTIVE: To investigate the anatomic feature of the posterior hip joint capsule and its distributional difference of collagen fibers and to probe the optimization of the capsulotomy which can reserve the best strength part. METHODS: Ten adult cadaver pelvises (6 males and 4 females, aged 28-64 years) fixed with formalin were used. Ten right hips were used for anatomical experiment of hip joint capsule. The posterior hip joint capsules were divided into 3 sectors (I-III sectors) and 9 parts (I(A-C), II(D-F), III(G-I). The average thickness of each part was measured and the ischiofemorale ligaments were observed. Five capsules selected from ten left hips were used for histological experiment. The content of collagen fibers in sector I and sector II was analyzed by Masson's staining. Two fresh frozen specimens which were voluntary contributions were contrasted with the fixed specimens. The optimal incision line of the posterior capsule was designed and used. RESULTS: The thickness in the posterior hip joint capsule [I(A) (2.30 +/- 0.40), I(B) (4.68 +/- 0.81), I(C) (2.83 +/- 0.69), II(D) (2.80 +/- 0.79), II(E) (4.22 +/- 1.33), II(F) (2.50 +/- 0.54), III(G) (1.57 +/- 0.40), III(H) (2.60 +/- 0.63), III(I) (1.31 +/- 0.28) mm] had no uniformity (P < 0.01). The III(G) part and the III(I) part were thinner than the I(B) part and the II(E) part (P < 0.01). Two weaker parts located at obturator externus sector (sector III), the ischiofemorale ligament trunk went through two thicker parts (I(B) and II(E)). The distribution of the collagen fibers in sector I and sector II(I(A) 20.34% +/- 5.14%, I(B) 48.79% +/- 12.67%, I(C) 19.87% +/- 5.21%, II(D) 17.57% +/- 3.56%, II(E) 46.76% +/- 11.47%, II(F) 28.65% +/- 15.79%) had no uniformity (P < 0.01). The content of collagen fibers in I(B) part and II(E) part were more than that of other parts (P < 0.01). There were no statistically significant difference in the distribution feature of the thickness and the ischiofemorale ligaments between the fresh frozen specimens and the fixed specimens. The optimal incision line C-A-B-D-E of the posterior capsule was designed and put into clinical application. The remaining capsular flap comprise the most of the ischiofemorale ligament trunk and the part of gluteus minimus. CONCLUSION: Although enhanced posterior soft tissue repair in total hip arthroplasty was investigated deeply and obtained great development, but the postoperative dislocation rate was not eliminated. It is significant for optimizing the capsulotomy to reserve the best strength part of the posterior capsule and to bring into full play the function of the ischiofemorale ligaments.     

原色原形病理标本改良制作法

原色标本对提高教学质量有一定帮助。根据文献，其制作方法有８种之多。作者参考文献，不断摸索，创作了既原色又原形的标本，兹介绍如下。１试剂配制１．１第一液标本固定液：９５％酒精３００ｍｌ、１０％福尔马林液３００ｍｌ、醋酸钾１００ｇ、蒸馏水加至１０００ｍｌ...     

NF-κBp50、p53、Bcl-2在子宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系

目的探讨子宫颈癌组织中NF-κBp50、p53、Bcl-2的表达及其与人乳头瘤病毒（HPV）感染的关系。方法采用免疫组织化学S—P法对46例子宫颈癌、26例正常子宫颈组织进行NF-κBp50、p53、Bcl-2蛋白检测；用PCR技术对各组织标本的HPV—DNA进行了检测。结果NF-κBp50、p53、Bcl-2蛋白在子宫颈癌组织中的表达率显著高于正常对照组（．P〈O．01）。NF-κBp50与p53或Bcl-2之间的表达具有相关性（P〈0．05），p53与Bcl-2之间无相关意义（P〉0．05）。在HPV—DNA阳性子宫颈癌组织中NF-κBp50的阳性率显著高于阴性组（P〈0．05）。p53、Bcl-2的阳性率在HPV—DNA阳性和阴性组之间差异无显著性（P〉0．05）。结论NF-κBp50、p53、Bcl-2的表达与子宫颈癌的发病有密切关系，HPV感染与NF-κBp50活化有关。     

地塞米松对庆大霉素和丁胺卡那霉素所致豚鼠耳毒性的保护作用

目的：观察地塞米松能否拮抗庆大霉素和丁胺卡那霉素所致的耳毒性。方法：取听力正常的豚鼠50只，雌雄各半，随机分为5组：庆大霉素组；丁胺卡那霉素组；庆大霉素 地塞米松组；丁胺卡那霉素 地塞米松组和生理盐水对照组。用药2wk后饲养1wk，检查中耳粘膜反应、眼震抑制率及耳蜗的形态学变化。结果：庆大霉素 地塞米松组与庆大霉素组比较；丁胺卡那霉素 地塞米松组与丁胺卡那霉素组相比有显著性差异。结论：地塞米松对庆大霉素与丁胺卡那霉素所造成的耳毒性有明显的保护作用。     

番茄红素对铁负荷大鼠肝细胞增殖和自噬的保护作用

<正>番茄红素(lycopene)是类胡萝卜素的一种,因最早发现于番茄中得名,有极强的清除自由基能力,预防和修复细胞损伤等。铁元素由于独特的化学反应活性,在能量代谢、细胞增殖和DNA修复中起重要所用。而机体过多的自由铁却通     

番茄红素对慢性铁负荷大鼠肝细胞自噬的保护作用

目的 :探讨番茄红素对慢性铁负荷大鼠肝细胞自噬的影响。方法:通过饲喂高铁饲料和灌胃番茄红素的方法构建SD慢性铁负荷模型,采用铁染色和透射电镜方法观察肝组织细胞的形态结构及其超微结构的变化,采用免疫组化方法观察肝组织切片中LC3-B蛋白的表达。结果:慢性铁负荷组与对照组及番茄红素组动物比较,肝细胞中有大量铁蛋白颗粒累积,线粒体和内质网膜膨胀,胞质中形成自噬前体,LC3-B微管相关蛋白有较强表达。结论:番茄红素能降低肝细胞中铁诱导线粒体膜的改变和细胞的自噬,具有一定的保护作用。     

急性心肌梗死再灌注治疗的紧迫与慎重

急性心肌梗死（AMI）是指冠状动脉急性闭塞,血流中断所导致的局部心肌缺血性坏死。引起AMI的原因可有多种,但基础病变大多为冠状动脉粥样硬化。AMI包括急性ST段抬高心肌梗死（STEMI）和急性非ST段抬高心肌梗死（NSTEMI）。20世纪80年代以来的研究表明,在冠状动脉粥样硬化斑块破裂的基础上血栓形成,使冠状动脉急性闭塞,     

心脏骤停287例抢救体会

目的探讨心脏骤停的抢救程序与方法 ,以提高心肺脑复苏成功率。方法回顾总结287例心脏骤停患者的临床资料,分析影响心肺复苏成功的因素。结果 287例患者复苏成功39例,成活14例,复苏成功率为13.6%,成活率为4.9%。结论心脏骤停患者复苏成功与其原发病、心肺复苏开始时间、复苏技术及合理使用复苏药物有关。