NLR、FAR、SCC-Ag对宫颈鳞状细胞癌患者术前淋巴结转移的预测价值#br#

Objective?To investigate the predictive value of neutrophil/lymphocyte ratio (NLR), fibrinogen/albumin ratio (FAR) and squamous cell carcinoma antigen (SCC-Ag) for preoperative lymph node metastasis in patients with cervical squamous cell carcinoma. Methods?A total of 213 patients with cervical squamous cell carcinoma admitted to the Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University from June 2013 to December 2016 were collected into our study and were divided into the metastatic group (61 patients) and non-metastatic group (152 cases). The histopathology, the serum level of SCC-Ag, neutrophil, lymphocyte, fibrinogen, albumin were determined and the NLR and FAR were calculated. Results?Compared with the non-metastatic group, the stageⅡclinical stage, SCC-Ag, lymphocyte count and albumin in the metastatic group were higher (P＜0.05). The Logistic regression model showed that NLR, FAR and SCC-Ag were risk factors for preoperative lymph node metastasis in patients with cervical squamous cell carcinoma (P＜0.05). The receiver operating characteristic curve (ROC) showed that NLR, FAR, SCC-Ag and NLR+FAR+SCC-Ag could be used to predict cervical squamous cell carcinoma lymph node metastasis, and the area under the curve(AUC) of NLR+FAR+SCC-Ag was the largest. Conclusions?Preoperative NLR, FAR and SCC-Ag increased in patients with cervical squamous cell carcinoma lymph node metastasis, and could be used as the risk predictors. NLR, FAR, SCC-Ag and NLR+FAR+SCC-Ag can predict preoperative lymph node metastasis in patients with cervical squamous cell carcinoma, and NLR+FAR+SCC-Ag has the highest effect value.     

妊娠与滋养细胞肿瘤

<正>滋养细胞肿瘤是我国较常见的妇科恶性肿瘤之一,绝大多数滋养细胞肿瘤继发于妊娠,称为妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN),仅有极少数滋养细胞肿瘤来源于卵巢或睾丸生殖细胞,称为非妊娠性绒癌。妊娠滋养细胞肿瘤主要包括侵蚀性葡萄胎、绒毛膜癌(简称绒癌)、胎盘部位滋养细胞肿瘤及上皮样滋养细胞肿瘤,由于侵蚀性葡萄胎     

社区居民糖尿病患病率、知晓率和控制率现况调查

目的了解社区居民糖尿病患病率、知晓率和控制率现状。方法随机整群抽取保定市3个社区,应用横断面研究方法调查45岁以上居民2型糖尿病患病、知晓和控制情况。结果糖尿病标化患病率20.1%,糖尿病前期标化患病率为7.8%;糖尿病知晓率为68.5%,糖尿病前期知晓率为0;达标率仅为17.91%。结论社区居民糖尿病患病率较高,知晓率和控制率较低,解决人群防治的关键是提高知晓率。     

一例活体肝部分移植术实验室监测

患者，女，１０岁，体重２４公斤，发育正常。临床诊断为先天性肝内胆管囊性扩张症。于１９９７年６月３０日在全麻下行病肝切除术，同时植入其父左叶肝脏。术后经过：手术历时１３小时，患儿在气管插管下返回病房，术后给予特级护理，密切监测生命体征变化，并于１９９７...     

穴位注射配合刺络法治疗慢性阻塞性肺部疾病疗效观察

目的探索穴位注射复方当归注射液与刺络法结合治疗慢性阻塞性肺部疾病临床疗效及对肺循环功能的影响。方法治疗组210例,依据辨证取穴,分别以定喘、肺俞、脾俞、天突、膻中、孔最、丰隆等为基础穴位,每穴分别注射复方当归注射液0.5m l,然后配合刺络法治疗;对照组50例,采用单纯针刺方法。治疗24次统计疗效。实验方法,应用光电RM-6000多导生理记录仪分别同步记录治疗前和治疗1个疗程后的心电图、心音图、肺阻抗图、一阶微分图,然后进行自身对照观察。结果穴位注射复方当归注射液配合刺络组总有效率为98.69%,肺阻抗血流图8项指标治疗前后对比均有显著意义(P(0.05~0.001);对照组总有效率为88%,肺阻抗血流图8项指标中,治疗前后对比4项有意义(P(0.05~0.01)。结论复方当归注射液穴位注射配合刺络法治疗慢阻肺疗效确切,明显优于对照组。并为评价临床疗效提供了客观指标,同时对穴位及刺络作用机制进行了探讨。     

SIRT1和p53在合并糖尿病子宫内膜癌的表达及意义

Objective To investigate the expressions and significances of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus. Methods Immunohistochemistry was carried out to examine the expressions of SIRT1 and p53 in 39 cases of endometrial carcinoma with diabetes mellitus and 40 cases of endometrial carcinoma without diabetes mellitus and 25 cases of normal endometrium, and the correlations between these indexs were analysed. Results The positive rate of SIRT1 and p53 in experimental group was 64.1％, 59.0％ respectively, and 85.0％, 52.5％ in control group. The positive rate of SIRT1 in experimental group was lower than control group (χ²=4.561, P=0.033). The positive rates of SIRT1 and p53 in control group were higher than normal endometrium (χ²=21.462, P＜0.001; χ²=6.771, P=0.009). Expression of SIRT1 was positively correlated with p53 (r = 0.360,P =0.024). Conclusions Hyperglycemia deregulates SIRT1 in endometrial carcinoma. SIRT1 may promote tumorigenesis by silence of p53.     

硫氧还蛋白相关蛋白14的研究

Thioredoxin-related protein 14 (TRP14), a new member of Trx family, is a novel disulfide reductase with conservative CPDC motif. Its structure and function are comparable to Trx, which is the representative member of Trx family. However, there are many differences. When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen, TRP14 can as a sensor of the intracellular redox state, change oxidation state of dynein lifht chain (its substrate), thereby regulate NF-κB signaling pathways induced by TNF-α, MAPK and apoptosis signaling pathways.     

腹腔外复发性卵巢癌及其治疗

多数上皮性卵巢癌在3年内复发,复发的主要部位是腹腔内。腹腔外复发性卵巢癌病例也不断有报道,也是目前卵巢癌治疗中最棘手的问题之一。对于初次治疗后出现的腹腔外病变,文献中的名称至今尚不统一,有称为复发,也有称转移或转移复发[1,2]。本文统一称为复发。1腹腔外复发性卵巢癌的概况近来有资料显示,在卵巢癌患者尸检中较多患者有腹腔外转移病变存在。Braun对108例新诊断的卵巢癌患者(I～III期)行骨髓检查,发现30%的病例骨髓中可找到癌细胞,骨髓中癌细胞阳性者与其后发生腹腔外转移有明显的相关性(RR=16.5),这说明卵巢癌患者血行播散不…     

参七片抗衰老作用的药效学研究

目的:观察参七片抗衰老的效果及作用机制.方法:将果蝇分为4组,每组雌雄各200只,分别给予浓度为0%,0.027%,0.080%,0.720%的受试物.每天定时统计果蝇存活数和死亡数,直至全部死亡,计算平均寿命和最高寿命以及半数死亡时间.将雌性小鼠40只,随机分为4组,分别给予人体推荐剂量(2.4g/60kg·bw)的5倍、10倍和30倍受试物,对照组灌蒸馏水,42天后处死小鼠,分别测定心肌脂褐素含量、血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-Px)含量.结论:参七片能够降低MDA含量,提高SOD及GHS-Px活力,减少心肌脂褐素含量,通过明显的抗氧化起到延缓衰老的作用.     

活体肝部分移植术后的实验室监测

0　引言　 1997- 0 6 ,我院为一名患先天性肝内胆管囊性扩张症的女性患儿成功地进行了活体肝部分移植 ,目前患儿存活140 d.现将其肝功、肾功、血细胞分析等的监测报告如下 .1　病例报告　女 ,年龄 10岁 ,体质量 2 4kg,发育正常 .临床诊断为先天性肝内胆管囊性扩张症 . 1997- 0 6 - 30在全身麻醉下行病肝切除术 ,同时植入其父左外叶肝脏 .用日立自动生化分析仪 ,日本东亚血细胞分析仪 ,日本第一化学、上海长征公司 Trace试剂盒 ,稍加改进 ,自编化学分析参数 ,程序、进行肝功 13项、肾功能、心肌酶谱及同 酶、脂类、C-反应蛋白(CRP)、前白…