预防内镜使用中医院感染的方法与效果

目的降低内镜使用中发生的交叉感染,探讨预防感染的措施。方法制订和完善内镜室管理制度,加强内镜消毒设施的投入;组织人员培训,规范清洁消毒工作程序。结果医院内镜清洗消毒工作逐步实现了标准化和规范化管理,内镜消毒灭菌合格率由流程改进前的96.95%上升到改进后的100.00%,感染率由流程改进前的2.01%下降为零。结论严格执行内镜清洗消毒技术操作程序及防护措施,可以预防内镜使用中发生的医院感染。     

基于大数据的中药注射剂不良反应自动监测方法研究

目的 研究基于大数据的中药注射剂不良反应自动监测的方法。方法 选取河北省中医院2018年至2020年药物不良反应(adverse drug reaction, ADR)报道率最高的5种中药注射剂,基于中国知网数据库中相关ADR大数据筛选报道最多ADR,选择其中可通过计算机手段进行监测的5类ADR生成ADR风险监测信号,设置监测规则,利用ADR自动监测软件对2021年我院中药注射剂进行实时ADR风险监测;以报告比数比(reporting odds ratio, ROR)法为风险信号评价方法,95%CI下限>1为有效风险信号产生条件进行风险数据挖掘。结果 ADR风险信号监测结果显示：参麦注射液在恶心呕吐、肾损害和白细胞减少三个不良反应上的95%CI下限大于1。挖掘到“喜炎平注射液致恶心呕吐”、“参麦注射液致肾损害”、“参麦注射液致白细胞减少”三个有效风险信号。其中喜炎平注射液致恶心呕吐217例,参麦注射液致白细胞减少14例,参麦注射液致肾损害5例。结论 中药注射剂ADR监测中应用基于大数据的ADR自动监测,可实现实时主动监测,提升工作效率,减少误报率,提升临床用药风险防范及管控能力。     

儿童松果体囊肿伴性早熟8例临床分析

我国儿童性早熟诊断标准是指女童8岁前、男童9岁前出现第二性征,按发病机理和临床表现可分为中枢性和外周性。中枢神经系统的病变（如颅内肿瘤、颅脑损伤、炎症后硬化等）可能导致中枢性性早熟。松果体分泌褪黑素,在生殖内分泌中发挥作用,参与青春期的调控,与青春期启动、性器官的发育和成熟以及促性腺激素24h的节律分泌有关,但其具体机制尚不明确。松果体囊肿多无明显临床症状,与性早熟的关系较少报道。     

特殊表现的儿童甲状腺功能亢进症6例临床分析

目的 总结儿童甲状腺功能亢进症(简称甲亢)的特殊临床表现及辅助检查、提高对临床症状不典型的儿童甲亢的认识,以早期诊断及治疗。方法 湖北省妇幼保健院儿童内分泌遗传代谢科2013年8月-2015年6月诊断的特殊临床表现的儿童甲状腺功能亢进症6例,回顾性分析其病史特点及诊治过程。结果 6例甲亢儿童中,伴有遗尿1例、尿频1例、胸痛伴食欲减退2例、慢性腹泻1例、生长加速1例,确诊前就医时间1~5月,曾分别诊断为遗尿症、神经性尿频、心肌炎,最终均经甲状腺功能等检查诊断为甲亢,并经抗甲状腺药物治疗后病情好转。结论 儿童甲亢的临床表现多种多样,常被误诊为出现主要症状系统的相关疾病,临床医师应详细询问病史,对伴有遗尿、尿频、心动过速、慢性腹泻、生长加速等症状的儿童,应考虑到甲亢可能,必要时进行甲状腺功能检测,以便准确诊断及治疗。     

国家中医临床研究基地临床科研信息共享系统初探——基于河北省中医院基地的实证研究

目的:构建临床科研信息共享系统,为临床研究提供数据支持。方法:采用C/S/S(Client/Web Service/DB Server)进行整体框架设计。结果:系统具有电子病历后结构化、专科专病数据仓库、数据集成与治理、中医临床辅助决策支持、名老中医传承、患者全息视图、临床研究课题服务、科研教学管理等8方面功能。结论:临床科研共享系统可通过进行多源异构数据的融合、清洗与转换,为临床研究提供完整、可靠的数据资源。     

神仙解语丹加减联合舌三针治疗中风后失语症51例临床疗效观察

目的:观察神仙解语丹加减联合舌三针治疗中风后失语症的临床疗效。方法:临床纳入102例中风后失语症患者,按随机数字表法分为2组各51例。2组均采用舒尔氏(Schuell)刺激法行言语康复训练,30 min/次,3次/周。其中51例患者采用舌三针治疗作为对照组,另51例在上述基础上加用神仙解语丹加减内服治疗作为观察组。疗程均为4周。采用中国康复研究中心失语症检查表(CRRCAE)评价言语功能;采用神经功能缺损程度评分量表(CSS)评价神经缺损伤功能,治疗前后各1次。结果:观察组失语症临床总有效率为96.08%,高于对照组的82.35%(χ~2=4.993,P0.05);治疗后2组患者CRRCAE检查表各因子评分均显著增高(P0.01);治疗后观察组CRRCAE检查表各因子评分均明显高于对照组(P0.01);治疗后2组患者CSS评分均显著低于治疗前(P0.01),且观察组CSS评分低于对照组(P0.01)。结论:神仙解语丹加减联合舌三针治疗中风后失语症患者,具有较好的临床效果,值得临床推广应用。     

艾灸神阙穴对运动性疲劳大鼠心肌重构及心肌功能的影响

目的:探讨艾灸神阙穴对运动性疲劳大鼠心肌结构及功能的影响.方法:采用12周跑台训练方式制造运动性疲劳大鼠模型.将符合条件的60只无特定病原体级雄性Sprague-Dawley大鼠随机分为空白组、对照组、模型组、非经非穴组、足三里组和神阙组,每组10只.空白组大鼠不进行运动训练也不进行艾灸,对照组大鼠不进行运动训练但温和...     

菖蒲醒脑汤治疗中风后轻度认知功能障碍临床观察

目的:观察在常规治疗基础上采用菖蒲醒脑汤治疗中风后轻度认知功能障碍(MIC)患者的临床疗效。方法:将符合纳入条件的98例肾精亏虚、痰浊瘀阻证患者按随机数字表法分为对照组和观察组各49例。2组均予常规控制血压、血脂、血糖,并针对中风后遗症进行康复治疗。对照组口服尼莫地平片治疗,观察组采用菖蒲醒脑汤内服。2组疗程均为12周。治疗前后评定简易精神状态(MMSE)量表、蒙特利尔认知评估(Mo CA)量表和日常生活功能(ADL)量表评分与中医证候评分。结果:认知功能疗效观察组总有效率为93.88%,高于对照组的79.59%(P0.05)。中医证候疗效观察组总有效率为95.92%,高于对照组的73.47%(P0.01)。治疗后,观察组Mo CA、MMSE和ADL量表评分均高于对照组,中医证候评分低于对照组(P0.01)。结论:在常规治疗基础上采用菖蒲醒脑汤治疗能提高肾精亏虚、痰浊瘀阻证中风后MIC患者的认知功能,改善症状,提高患者的生活质量,其疗效优于服用尼莫地平片。     

乙醇对猪红细胞电泳率影响的实验研究?

目的探讨乙醇的细胞膜毒性及其机制,研究食用酒精对猪红细胞电泳率的影响。方法配制体积比为1%的红细胞溶液,向4mL红细胞溶液中加入不同剂量的食用酒精,在水浴中培养30min后测量其电泳率。结果当加入酒精剂量小于20μL时,红细胞电泳率随酒精剂量的增加而增加;大于20μL时,电泳率随酒精剂量的增大而减小。结论电泳率的变化表明酒精对红细胞的形态结构和表面电荷特性有重要的影响,这对于阐明乙醇的毒理学特征和机制都具有十分重要的意义。     

Effect of moxibustion at Shenque (CV 8) on free radical metabolism in rat’s hippocampus after different degrees of exhaustive exercise

Objective

To investigate the effect of moxibustion at Shenque (CV 8) on free radical metabolism in rat’s hippocampus after different degrees of exhaustive exercise.

Methods

A total of 72 male Sprague-Dawley (SD) rats were randomly divided into a normal group (n=8), a model group (n=32) and a moxibustion group (n=32). According to the times of modeling or treatment, the model group was further randomly divided into different subgroups of a 1-time model subgroup, a 4-time model subgroup, a 7-time model subgroup and a 10-time model subgroup (n=8); the moxibustion group was also further randomly divided into different subgroups of a 1-time moxibustion subgroup, a 4-time moxibustion subgroup, a 7-time moxibustion subgroup and a 10-time moxibustion subgroup (n=8). Rats in both model and moxibustion subgroups were subjected to establishing the swimming exhaustive model. Rats in each moxibustion subgroup received mild moxibustion at Shenque (CV 8) for 15 min immediately after modeling, once every other day. The concentration of malic dialdehyde (MDA), as well as the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) in rat’s hippocampus in each group were detected 24 h after the exhaustive exercise.

Results

Compared with the 1-time model subgroup, the exhaustive swimming time of rats was significantly prolonged in the 4-time model subgroup (P<0.01), while it was significantly shortened in the 7-time and 10-time model subgroups (both P<0.01). Compared with the matched model subgroup, the exhaustive swimming time of rats in the 7-time and 10-time moxibustion subgroups was significantly prolonged (both P<0.01). Compared with the normal group, the MDA concentration was increased significantly (P<0.01), and the activities stress response of SOD and T-AOC were increased in the 1-time model subgroup (both P<0.05); the MDA concentration was increased (all P<0.01), and the activities of SOD, GSH-Px and T-AOC were decreased differently (P<0.05 or P<0.01) in the 4-time, 7-time and 10-time model subgroups. Compared with the matched model subgroup, the concentration of MDA was significantly reduced (P<0.05 or P<0.01), and the activities of SOD, GSH-Px and T-AOC were significantly increased in the 4-time, 7-time and 10-time moxibustion subgroups (all P<0.01).

Conclusion

Moxibustion at Shenque (CV 8) can improve the fatigue status of the body after long-term exhaustive exercise by regulating free radical metabolism in rat’s hippocampus. To some extent, this provides an experimental basis for moxibustion at Shenque (CV 8) against exercise-induced fatigue.