临床联合用药的合理应用

合理用药对疾病的治疗具有非常重要的意义，现就常见的临床联合用药的合理应用分述如下。     

老年脑力劳动者体液免疫功能检测

多数学者指出,机体免疫功能随年龄增长而下降。本文用六项免疫指标对416例健康老年脑力劳动者体液免疫功能进行了检测,并以健康中年体力劳动者做对照,结果报告如下。材料与方法对象:老年健康脑力劳动者男215例,年龄55～68岁;女201例,年龄51～64岁。经体格检查合格者(血尿便常规、肝功、二     

EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON EXTRACELLULAR ADENOSINE AND EVALUATION OF ITS PROTECTIVE EFFICACY IN ISCHEMIC REPERFUSION RAT——Microdialysis, HPLC and Histopathologic Studies

The effects of Radix Salviae Miltiorrhizae (RSM) on extracellular adenosine (Ade) and its metabolites, Le. inosine, hypoxanthine and xanthine, were studied with microdialysis and HPLC techniques during cerebral ischemia-reperfusion induced by 4-vessel occlusion in rat brain. Histological examination of hippocampus was performed 6h after reperfusion. ECF (extracellular fluid) adenosine and its metabolites were compared, between the controls (n= 6) and RSM-treated rats (n= 6). Basal level of Ade and its metabolites release were not greatly affected by pretreatment with RSM, and no significant difference as compared with the sham-operated (n= 6). Ade and its metabolites were dramatically increased after ischemia, and decreased near basal-level and its metabolites remained high at the end of reperfusion. In the RSM-treated animals, the tendency of changes of Ade and its metabolites was just the same as in the controls, but the magnitudes of changes were significantly lower at some different tune points. In sham-operated animals, no changes were observed at different time points both during ischemia (30 min.) and reperfusion (60 min.). Histopathological findings demonstrated that RSM pretreatment results in better histologic preservation of the pyramidal cells in the postischemic reperfusion CA1 sector both qualitatively and quantitatively. These results indicated that RSM protects against cerebral ischemia reperfusion injury.     

中医科研设计中常见弊端浅析

把统计学的原理和方法应用到中医科研过程中，尤其是进行科学的设计，将会使研究更加合理、有效。笔者从众多的中医科研论文中发现了一些常见的带有普遍性的设计问题，即统计学设计不完善、处理因素的确定单一、受试对象选择偏颇等８种弊端及纠正的方法。     

中医统计学教学面临的问题与对策

中医统计学是以概率论和数理统计的原理和方法为基础，以中医理论与实践为主体，以数据搜集、整理、分析和推断为手段，以探讨医学生命现象和中医理论与方法的内在客观规律为目的的方法学。随着中医现代化进程的推进，利用统计学的方法，从数量的角度寻求医学现象发生的规律显得越来越重要。     

Kasabuch-Merritt综合征1例

Kasabuch-Merritt综合，止义称血管瘤伴血小板减少综合征陔病多见小儿，成人下见我科收治1例,结合文献报告如下     

冻干重组碱性成纤维细胞生长因子无人血清白蛋白保护剂的研究

目的在冻干重组碱性成纤维细胞生长因子制剂中引入一种无人血清白蛋白保护剂。方法采用 3种药用辅料按一定比例配制保护剂。结果加入无人血清白蛋白保护剂的 3批供试品 ,成品各项检查均合格。生物效价在 (40± 2 )℃、(2 5± 2 )℃、2℃～ 8℃保存分别达 6、12、3 0个月。结论在重组碱性成纤维细胞生长因子冻干制剂中无人血清白蛋白保护剂可以替代人血清白蛋白     

头孢克洛分散片在人体中的药代动力学和生物利用度

目的： 测试国产头孢克洛分散片在8 名健康男性志愿者体内的药代动力学和相对生物利用度。方法：采用 HPLC 法测定血、尿药浓度, 比较了单剂量口服 500 mg头孢克洛分散片和普通胶囊的体内过程和生物利用度。结果：头孢克洛分散片的药代动力学符合一室开放模型。试验药品和对照药品的cmax分别为（15.87±4.54）和 （13.75±4.54）μg/ml; tmax分别为（0.63±0.19 ）和（0.66±0.19）h; t1/2 分别为（0.54±0.13）和（0.63±0.20）h; AUC0？∞分别为（19.13±2.82）和（18.30±3.62）h*μg/ml。试验药品的相对生物利用度为（106.59±19.13）％。结论：两种制剂的AUC及其对数形式经三因素方差分析和双单侧t检验均无显著性差异,提示两者具有生物等效性。     

缺氧缺血与线粒体DNA损伤

线粒体ＤＮＡ（mitochondrial DNA, mtDNA）是唯一的核外遗传物质，为编码线粒体呼吸链复合物的重要组成部分，在细胞能量代谢中起重要作用。缺氧缺血情况下ｍｔＤＮＡ易发生损伤，自由基、一氧化氮产生增多是ｍｔＤＮＡ损伤的主要因素。缺氧缺血时ｍｔＤＮＡ损伤可致细胞凋亡、线粒体呼吸链复合物活性下降，并且不同的组织ｍｔＤＮＡ损伤有不同的表现形式。