精神科护士的多种角色

对精神科护士的多种角色进行了阐述,揭示了其工作的特殊性和重要性。指出:要想做一个称职的护士,成功的完成各种角色功能,关键问题是要不断学习,不断总结经验。     

烫伤大鼠细胞免疫抑制与肠源性内毒素血症的关系

采用大鼠４０％ＴＢＳＡⅢ度烫伤模型，将动物随机分烫伤对照组和选择性消脱污染防治组，探讨烫伤大鼠全身性细胞免疫抑制与肠源性内毒素血症的关系。结果显示，大鼠４０％Ⅲ度烫伤后脾细胞对促有丝分裂原增殖应答反应、诱生白介素－２（ＩＬ－２）活性及Ｔ细胞亚群（Ｔｈ／Ｔｓ）比值明显下降，预防性进行ＳＯＤ动物，内毒素血症发生率显著降低，脾细胞增殖应答反应和ＩＬ－２活性的诱生能力均明显恢复（Ｐ〈０．０５￣０．０１），     

短期使用抗精神病药血糖浓度变化初步观察

糖尿病是一组由遗传和环境因素相互作用而引起的临床综合征[1] ,临床以血糖升高为共同标志。近年来 ,在普通人群中糖尿病有居高不下趋势 ,在精神分裂症患者中该患病率更高 ,引起血糖升高的原因很多 ,值得精神科临床医师加以重视 ,本文对此进行短期的临床观察 ,探讨其预防办法。1　对象与方法1 1　研究对象　选自本院男病房 ,共 134例 ,均符合CCMD -Ⅱ -R精神分裂症诊断标准[2 ] 。排除其他精神疾病和脑器质性疾病及糖尿病史者。最大年龄 75岁 ,最小年龄 2 2岁 ,平均 (4 7 4 3± 11 4 6 )岁 ;最大病程 5 5年 ,最短 3年 ,平均 (2 4 98± 13…     

正常人及大鼠心脏内皮素转换酶的分布

目的:了解正常人和大鼠心脏各部分内皮素转换酶(Endothelin-conveerting en-zyme,ECE)的分布。方法:采用半定量RT-PCR法检测ECE mRNA表达,同时根据外源性的巨内皮素-1转变为内皮素-1的量判定ECE活性。结果:正常人心脏各部位心肌均存在ECE,ECEmRNA表达和活性的分布特点一致:心房显著高于心室,左、右心房间及左、右心室和室间隔间无显著性差异。大鼠的ECE mRNA表达和活性分布规律与人相似。结论:正常人和大鼠心脏各组分均存在ECE,且两者的分布规律相似。     

颈淋巴结活检后的鼻咽癌22例疗效分析

本文报道２２例颈淋巴结活检后的鼻咽癌患者，放疗结束时颈淋巴结残留占３１．８％，颈部照射野处皮肤湿性反应占４０．９％，远处转移率高达７７．２％，放疗反应重，效果差，５年生存率仅为１８．２％。而５６例经鼻咽原发灶活检的鼻咽癌放疗效果好，五年生存率达５３．１％。本文提示，鼻咽癌经颈淋巴结活检是放疗失败的重要原因之一。     

变异型心绞痛的发作诱因和合并症

本文报告3例饮酒诱发变异型心绞痛者,2例发展为急性心肌梗塞,1例合并Ⅲ度房室传导阻滞.另3例无诱因的典型变异型心绞痛发作皆无合并症.上述结果提示:饮酒是变异型心绞痛发作的最常见诱因,与无诱因者相比,予后更为严重.因此,有冠状动脉痉挛倾向者如变异型心绞痛,不稳定型心绞痛,卧位或夜间发作的心绞痛等,应避免饮酒.     

除去白细胞的输血

负责研讨血液安全的日本厚生劳动省专家调查会4月 2 3日决定 ,将在日本启动除去白细胞的输血。由于白细胞可成为输血后急性肺功能障碍等重症副作用的原因 ,英国、法国、德国、加拿大等国已 1 0 0 %地实施了除白细胞输血 ,美国也在引入这一机制。该调查会指出 ,输血用血液除去白细胞后 ,除减少急性肺功能障碍外 ,还可减少细菌感染、发热等副作用。即使万一有变异型雅各布病患者献血 ,也能大幅度降低其危险性。除去白细胞的输血@徐爽 @盛志业     

Analysis of differentially expressed genes in fetal skin of scarless and scar-forming periods of gestational rats

Objective: To study the differences of gene expression between earlier gestational skin and later gestational skin of rats with the aids of single primer amplification (SPA) and high-density oligonucleotide DNA array to understand the molecular mechanism of scarless healing. Methods: Total RNAs were isolated from fetal rat skin of the scarless (E15) and scar-forming (E18) periods of gestation (term =21.5 days). The RNAs from earlier gestational skin (EGS) and later gestational skin (LGS) were both reversely transcribed to cDNAs, then labeled with the incorporation of fluorescent dCTP for preparing the hybridization probes by SPA method. The mixed probes were then hybridized to the oligonucleotide DNA arrays which contained 5 705 probes representing 5 705 rat genes. After highly stringent washing, these DNA arrays were scanned for fluorescent signals to display the differentially expressed genes between the 2 groups of skin. Results: Among 5 705 rat genes, there were 53 genes (0.93%) with differentially expressed levels between EGS and LGS groups, 27 genes, including fibroblast growth factor 2 ( FGF2 ) and follistatin were up-regulated (0.47%) and 26 genes were down-regulated (0.46%) in fetal skin during scarless period versus scar-forming period. Higher expressions of FGF2 and follistatin in EGS than those in LGS were also revealed by RT-PCR method. Conclusions: High-density oligonucleotide DNA array provided a powerful tool for investigating differential gene expression in earlier and later gestational fetal skins. This technology validates that the mechanism of fetal scarless healing is very complicate and the change of many gene expressions is associated with fetal scarless healing.     

50例传染性非典型肺炎患者合并肝功异常临床分析

传染性非典型肺炎(SARS)是一种由新型变异冠状病毒感染，主要以呼吸道感染为主的新的呼吸道传染病。该病传染性强，病情进展快，除对肺组织损伤严重外，对肝、心等脏器均有损害，尤其对肝组织损害较为常见。现将我们对解放军小汤山医院5区住院治疗的50例“非典”患病历进行总结，发现绝大部分患肝功能均有不同程度的损害，现总结分析如下。