急性暴露O_3后对大鼠肺中基本金属元素的影响

本文探讨了较高浓度的O_3对大鼠肺组织一些金属元素含量的影响。结果表明,肺重量、肺重/体重、及全肺Na含量,随暴露时间的延长而增加;全肺Ca、Cu含量变化的总趋势是暴露O_3后增加;全肺Zn、Mg、K含量于暴露O_38小时均增加,其后下降,但各组间无显著性差异;全肺Fe含量暴露后持续升高,但各组含量无显著性差异。     

肩三针埋线综合治疗肩周炎

肩三针埋线综合治疗肩周炎山西省针灸研究所（０３００１２）牛庆强，王宝生关键词肩关节周围炎，综合治疗肩关节周围炎简称肩周炎，是肩部肌肉、肌健、关节囊等组织的退行性病变，肩关节周围炎，中医学称“五十肩”、“漏肩风”、“肩凝症”、“冻结肩”，属于痹症范畴。...     

采用聚合酶链反应技术诊断疱疹性眼病

采用聚合酶链反应技术诊断疱疹性眼病山西省眼科医院（０３０００２）关姣莲山西省卫生防疫站郝利新，王左锋ＰＣＲ技术可以认为是体外模拟天然ＤＮＡ复制过程的一项新技术，其基本原理是：模板ＤＮＡ在热变性作用下解链，然后变性使引物特异地结合到互补模板上，再在ＤＮ...     

磁共振成像在颈部肿物诊断中的应用——附七例临床病例分析

本文收集了1992.8～1994.6期间我院收治颈部肿物患者7例,均经手术病理证实术前均行磁共振成像(MRI)检查,现就有关MRI诊断和对治疗的指导作用进行探讨。     

铅对女工及其子代健康的影响

前言 五十年代以来,我国在铅对女工及其子代健康的影响研究方面作了一些工作。迄今,全国已发表论文75篇,共计调查了6,215人。其中包括1987年11月第一届全国妇女劳动卫生学术讨论会13篇、调查2,778人。按论文性质可分为综述性19篇、对女工健康影响9篇、对子代健康影响27篇、动物实验及细胞遗传毒性13篇。生     

Responses of CDKs and p53 in Delayed Ischemic Neuronal Death

Stroke is a debilitating disease that affects millions each year.While in many cases cerebral ischemic in jury can be limited by effectivw resuscitation or thrombolytic treatment,the injured neurons wither in a process known as delayed neuronal death(DND).Mounting evidence indicates that DND is not simply necrosis played out in slow motion but apoptosis is triggered.Of particular interest are two groups of signal proteins that participate in apoptosis-cyclin dependent kinases(CDKs) and p53-among a myriad of signaling events after an ischemic insult.Recent investigations have shown that CDKs,a family of enzymes initially known for their role in cell cycle regulation,are activated in injured neurons in DND.As for p53,new reports suggest that its up-regulation may represent a failed attempt to rescue in jured neurons,although its up-regulation was previously considered an indication of apoptosis.These observations thus rekindle an old quest to identify new neuroprotective targets to minimize the stroke damage.In this review,the author will examine the evidence that indicates the participation of CDKs and p53 in DND and then introduce pre-clinical data to explore CDK inhibition as a potential neuroprotective target.Finally,using CDK inhibition as an example,this paper will discuss the pertinent criteria for a viable neuroprotective strategy for ischemic in jury.