足月引产与新生儿窒息和高胆红素血症的关系

目的：通过对足月引产分娩的新生儿窒息、新生儿高胆红素血症的分析，提高对正确掌握足月引产指征的认识。方法：对１９６例新生儿进行回顾性分析。结果：两年间引产一次成功者与足月妊娠自然分娩的新生儿窒息发生率无差异（Ｐ〉０．０５），而引产两次方能阴道分娩则有统计学差异（Ｐ〈０．０５）；引产之新生儿的高胆红素血症发生的高于自然分娩，分别是：引产一次组１０．２７％，对照组２．８３％，（Ｐ〈０．０５），引产二次组     

70例慢性肝炎新旧分类诊断的对照分析

作者对经肝穿刺活检证实的７０例慢性乙型肝炎病人，依据病理检查结果，将新旧分类法进行对照分析，旨在探讨其内在联系以及对临床诊断和治疗的指导意义。１临床资料１．１一般资料７０例慢性乙型肝炎病人中男５９例，女１１例。年龄１７～６０岁，平均３４．６岁。病史０...     

痛经停对血液流变性的影响

目的：研究痛经停治疗原发性痛经的作用机理。方法：应用自身给药前后对照方法，观察痛经停对实验家兔血液流变学指标的影响。结果：痛经停能降低全血比粘度，血浆比粘度和红细胞压积。结论：该药有降低血粘度，增强血液流动性，促进血液循环，改善组织缺血缺氧状态的作用。     

脂氧素A4对心肌缺血再灌注损伤的保护作用

Objective To investigate the roles of lipoxin A4, an endegenous lipid mediator with wide anti-inflammatory fea- tures, in attenuating myocardial ischemia-reperfusion injury and the possible mechanisms. Methods Thirty male KM mice were divid- ed randomly into three groups, 10 in each: ischemia-reperfusion group (group A), lipoxin A4 (0.1 mg/kg) group (group B) and Zn- PP (Zinc protoporphyrin Ⅸ, 25 mg/kg)phus lipoxin A4 (0.1 mg/kg)group (group C). A ischemia-reperfusion heart model was de- veloped by ligating the lift anterior descending branch of the coronary artery. A dine of 10% dehydrated alcohol in 0.2 ml for group A, a dose of isochoric lipoxin A4 for group B and a dose of isochoric ZnPP + lipoxin A4 for group C was infused into the ascending aorta through a catheter, which was kpassing the right common carotid artery, 30 minutes after reperfusion. The concentration of serum TNF-α, activities of serum crestine kinase(CK) and lactate dehydrogenase (LDH), activities of myeloperoxidase (MPO) and malond- ialdehyde (MDA) and the cell apoptosis rate in the myocardial tissue were measured 5 hours after reperfusion. Pathological features of the inflammatory infiltration in the myocardium were also observated.Results As compared with group A, the inflammatoryry infiltra- tion in the ischemic and necrotic regions tithe myocardium was reduced, with group C in the intermediate range. The serum activities of CK and LDH wine significantly lower in group B and C than that in group A, and the lowest activities were detected in group B. Similar findings were observed for MPO, an indicator for neutrophil infiltration, and MDA, an indictor for cell injury caused by oxy- gen radicals, in the myocardium. The concentration of TNF-α and the rate of cadiocyte apoptosis were decreased significantly in group B(P < 0.01). ZnPP, an inhibitor of heine oxygenase (HO)-1, attenusted the above protective effects of lipoxin A4 significantly (P<0.05). Conclusion Lipoxin A4 has protective effects against myocardial ischemia-reperfusion injury, and HO-1 may have a potential role in the protectve mechanisms of lipoxin A4, probably pertly by means of reducing the production of reactive oxygen spe- cies and TNF-α, decreasing the activation and infiltration of neutrophils, alleviating inflammatory damage and avoiding apoptosis.     

结膜及睑板淀粉样变性一例

患者女,58岁.左眼睑无痛性包块20年余,逐渐长大,伴左上睑下垂11年,当地医院曾诊断为"沙眼",行左上睑结膜病变刮除术,2009年10月26日到我院就诊,当时不明肿物性质,以"左眼睑新生物"收入院.眼部检查:视力:右眼0.8,左眼0.5,眼压:右13.2mmHg,左12.6mmHg.左上睑可触及23mm×11mm肿物,左上睑机械性下垂,遮盖瞳孔区近一半,提上睑肌肌力正常,左眼下睑可触及13mm×5mm串珠样肿物,上下睑肿物均质硬,边界较清,触痛(-),相应睑结膜黄色增生肥厚,表面粗糙.     

小脑出血的研究

小脑出血临床并不少见,但缺乏指导性的症状和体征,易误诊。若延误治疗,病死率较高,值得临床医生注意。发病情况有人在1932～1960年发表了5篇尸检报告,尸检63822例,发现颅内出血2417例,其中小脑出血146例,占颅内出血的6.1%。在美国自发性脑     

甲亢散发型无痛性甲状腺炎的诊断与治疗

目的　探讨散发型无痛性甲状腺炎 (SPT)在甲亢中的发病率、临床表现、实验室检查特征及不同治疗方法对其预后的影响。方法　从临床表现为甲亢的 2 76例患者中 ,诊断出 4 3例SPT ,随机分为治疗组 2 2例 ,对照组 2 1例 ,进行临床研究。结果　SPT的发病率为 15 5 8% ,其相关的实验室检查不同于Graves病、毒性甲状腺腺瘤 (Plummer病 )及桥本病 (Hashimoto病 ) ;治疗组 :甲状腺毒症期 (37 2 3± 4 2 8)d ,正常甲状腺血症期 (16 4 3±3 4 2 )d ;低甲状腺毒症期 (18 6 5± 6 31)d ,复发率 4 5 4% (1/2 2 )无永久性甲低发生 ;对照组 :甲状腺毒症期 (6 8 35± 8 2 3)d ,正常甲状腺血症期 (31 4 5± 7 2 3)d ;低甲状腺毒症期 (10 2 4 2± 2 1 34)d ,复发率 14 2 8% (3/2 1) ,永久性甲低发生率 9 5 2 % (2 /2 1)。结论　甲亢中 ,SPT仅次于Graves病而较Plummer病及Hashimoto病多发 ,实验室检查对鉴别诊断意义大 ,相关治疗可较快控制甲亢症状、降低复发率及减少永久性甲低发生     

193 nm氟化氩激光应用于屈光性角膜切削的精确性及预测性

1975年有学者发现了准分子激光并将它应用于角膜屈光性手术，使屈光手术有了重大突破，成为现代眼科学中发展最快的领域之一。波长为193 nm的氟化氩激光可以使角膜组织分子气化，故准确度非常高，而且对于被照射部位旁边的组织不产生热效应，对角膜的构造不会产生不良的效应。目前准分子激光已成功应用于角膜放射状切开术、准分子激光屈光角膜切削术、准分子激光原位角膜磨镶术、准分子激光角膜上皮瓣下磨镶术及机械法准分子上皮下角膜磨镶术等。随着对准分子激光认识的不断深入，以及临床经验的不断积累，新的、精确度高的、预测性好的准分子激光屈光性角膜手术方式将不断涌现。