经皮耳迷走神经刺激干预功能性消化不良模型大鼠的效应及机制研究

ObjectiveTo explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation (taVNS) for the functional dyspepsia (FD) model rats.MethodsOf the 25 male SD rats, 6 rats were set as blank group, the other 19 rats were established to be the functional dyspepsia (FD) model by iodoacetamide intragastric administration, and 18 FD models were successfully established. The 18 model rats were randomly divided into a model group, a sham-taVNS group, and taVNS group, with 6 rats in each group. There was no intervention applied to the rats in the blank and model groups. Whereas, the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides, and those in taVNS group received stimulation to the cavity of auricular concha of both sides, for 30 min each time, once a day, 7 days in succession. After the intervention, the gastric sensitivity of the rats in each group under different pressure conditions in the stomach, the expressions of serum brain-gut peptide motilin (MTL), cholecystokinin (CCK), glucagon-likepeptide1 (GLP-1), and inflammatory factors IL-4, IL-10, and IL-1β were detected.Results(1) Gastric sensitivity: compared with the blank group, the gastric sensitivity of the model group was higher (P <0.05). Compared with the model group, the gastric sensitivity of the taVNS group was lower (P < 0.05). Compared with the sham-taVNS group, the gastric sensitivity of the taVNS group was lower (P <0.05).(2) Expression of brain-gut peptide: compared with the blank group, MTL was lower, CCK and GLP-1 were higher in the model group (all P <0.05). Compared with the model group, MTL was higher, CCK and GLP-1 were lower in the taVNS group (all P <0.05). Compared with the sham-taVNS group, CCK and GLP-1 were lower in the taVNS group (both P<0.05). (3)Expression of inflammatory factors: compared with the blank group, IL-4 and IL-10 were lower and IL-1β was higher in the model group (all P <0.05). Compared with the model group, IL-10 was higher and IL-1β was lower in the sham-taVNS group (all P <0.05), while IL-4 and IL-10 were higher and IL-1β was lower in the taVNS group (all P <0.05). Compared with the sham-taVNS group, IL-4 and IL-10 were higher and IL-1β was lower in the taVNS group (all P <0.05).ConclusionTaVNS can reduce the gastric sensitivity of FD model rats by peripheral anti-inflammatory action and regulating the abnormal secretion of brain-gut peptide.     

MEBO治疗化疗药物渗漏致皮肤损害及静脉炎的疗效观察

目的：探讨临床化疗药物渗漏所致患者皮肤损害及静脉炎的有效治疗方法。方法：应用ＭＥＢＯ治疗１８例化疗药渗漏致皮肤粘组织损害及化学性静脉炎患者,并同应用传统的普鲁卡因局部封闭硫酸镁湿敷治疗１８例患者进行了疗效对照观察。结果：ＭＥＢＯ组临床治疗３周总有效率为１００％,治愈率为７２．２％,对照组临床治疗总有效率为７２．２％治愈率为３３．４％。结论：ＭＥＢＯ在治疗化疗药物渗漏所致皮肤损害及静脉炎的临床止痛、创而修复、治愈时间等方面优于对照治疗组。     

小儿扩张型心肌病的临床特点及治疗随访分析

<正>扩张型心肌病(dilated cardiomyopathy,DCM)是最常见的心肌病,发病机制尚不清楚,其特征为心脏扩大、左心收缩功能不全发生心力衰竭[1],小儿与成人比较有不同之处。     

ICU医院感染原因分析及护理对策

ICU是集中危重症患者病情监测和治疗的单位,也是医院易感人群和感染因素集中的场所,是医院感染的高危区域。为降低ICU医院感染率,我院自2004年2月～2006年6月对     

自体角膜缘干细胞移植治疗翼状胬肉的疗效分析

麻醉性镇痛药由于易产生依赖性（盐酸麻黄素注射液可以制毒品）,用之得当,可治疗疾病、减轻痛苦,否则就会成瘾,有毒副作用。国家对麻醉性镇痛药实行特殊管理办法,因而在临床上受到严格限制。1资料与方法 1.1资料来源：2008年我院住院药房麻醉性镇痛药品专用帐册的数据、处方及处方登记册为调查资料。     

肝细胞癌诊断中 CT 灌注成像的应用探析

目的：对肝细胞癌诊断中 CT 灌注成像的应用进行分析探讨,为今后的临床诊断工作提供可靠的参考依据。方法抽取在2011年1月至2014年10月我院收治的临床确诊肝细胞癌患者45例,对其在入院后与治疗后分别展开 CT 灌注成像,并对检查结果进行对比分析。结果经统计,治疗后患者肝脏血流量、肝脏血容量、肝动脉供血分数较治疗前发生显著降低（P ﹤0.05）,平均通过时间明显延长（P ﹤0.05）,感兴趣区肝动脉灌注值、门静脉灌注值和肝动脉灌注值均较治疗前发生明显降低（P ﹤0.05）。结论 CT 灌注成像能够对肝细胞癌血供情况进行反映,能够为肝细胞癌的临床诊断、预后评估提供可靠的参考依据,值得关注。     

以长期发热为表现的小儿风湿性疾病39例临床分析

<正>长期发热是指持续发热2周以上,体温≥37.5℃的发热,病因复杂,诊断较困难[1]。风湿性疾病是小儿长期发热常见病因之一,其所占比例近年有上升趋势[2]。本文就近6年来收住院的以长期发热为临床表现的风湿性疾病39例患儿的临床资料进行分析。报告如下。     

480例母乳喂养的体会

目的:通过对480例产妇母乳喂养的临床观察,寻找缩短初乳分泌时间及增加泌乳量的有效措施。方法:正常足月分娩产妇,排除妊娠合并症或妊娠并发症,分为实验组和对照组,实验组采用产前母乳喂养宣教、做好乳房护理和营养准备、实施爱母分娩行动、产后半小时开奶、家庭化病房及母婴同室、指导产妇正确哺乳等方法;对照组产前未进行母乳喂养宣教,未采用陪伴分娩,住普通病房,仅产时产后进行母乳喂养知识宣传及指导。结果:实验组产后24h、48h、72h纯母乳喂养率明显高于对照组(P<0.01),新生儿一般情况及出现黄疸均好于对照组。结论:加强产妇综合护理,能缩短产妇产后泌乳时间,增加泌乳量为纯母乳喂养的成功创造良好条件。     

健康教育护士在糖尿病患者中的作用

目的探讨健康教育在糖尿病患者护理所起的效果,从而提高糖尿病患者自我管理。方法从2013年3月至2014年3月确诊的170例糖尿病患者,随机分为两组(对照组和健康教育组),对照组给糖尿病护理常规,健康教育组在糖尿病护理常规的同时,定期给糖尿病健康教育。结果健康教育组在掌握糖尿病相关知识、自我监测、血糖控制,均优于对照组。结论对糖尿病患者实施健康教育,使患者增加健康意识,自觉进行观念、运动、心理、药物治疗、自我监测的管理,可提高糖尿病患者生活质量,从而达到治疗印的。     

加强呼吸机清洗消毒预防医院感染

呼吸机是急救医学中一种不可缺少的重要设备，在临床应用中，人们往往只重视操作方法而忽略了使用前后的清洗消毒工作，导致医院感染。