静功的双合十姿势

两手掌及十指相合称为手合十，两脚掌及十趾相合称为脚合十。同时做手合十与脚合十称之为双合十。练静功的双合十姿势，可分为坐式与卧式。一、坐式坐于床上，臀下垫蒲团或者枕头，使脚低于臀部１０～２０厘米。或坐于大方凳上。若无大方凳，可用一高一低（相差１０～２０厘米）两个普通方凳。臀部坐于高凳上，脚置于低凳上。头正身直，目微合，口轻闭，全身放松，面带笑容。双手双脚用力搓热，然后手掌及十指紧贴相合，指尖向下，平对鼻梁。两脚掌及十趾亦相对紧合，趾尖向前，要求脚趾尖、会阴、肚脐、鼻梁及手指尖在同一垂直面上。脚合十…     

Respiratory Mechanics during Xenon Anesthesia in Pigs: Comparison with Nitrous Oxide

Background: Because of its high density and viscosity, xenon (Xe) may influence respiratory mechanics when used as an inhaled anesthetic. Therefore the authors studied respiratory mechanics during xenon and nitrous oxide (N2O) anesthesia before and during methacholine-induced bronchoconstriction.

Methods: Sixteen pentobarbital-anesthetized pigs initially were ventilated with 70% nitrogen-oxygen. Then they were randomly assigned to a test period of ventilation with either 70% xenon-oxygen or 70% N2O-oxygen (n = 8 for each group). Nitrogen-oxygen ventilation was then resumed. Tidal volume and inspiratory flow rate were set equally throughout the study. During each condition the authors measured peak and mean airway pressure (Pmax and Pmean) and airway resistance (Raw) by the end-inspiratory occlusion technique. This sequence was then repeated during a methacholine infusion.

Results: Both before and during methacholine airway resistance was significantly higher with xenon-oxygen (4.0 +/- 1.7 and 10.9 +/- 3.8 cm H2O [middle dot] s-1 [middle dot] l-1, mean +/- SD) when compared to nitrogen-oxygen (2.6 +/- 1.1 and 5.8 +/- 1.4 cm H2O [middle dot] s-1 [middle dot] l-1, P < 0.01) and N2O-oxygen (2.9 +/- 0.8 and 7.0 +/- 1.9, P < 0.01). Pmax and Pmean did not differ before bronchoconstriction, regardless of the inspired gas mixture. During bronchoconstriction Pmax and Pmean both were significantly higher with xenon-oxygen (Pmax, 33.1 +/- 5.5 and Pmean, 11.9 +/- 1.6 cm H2O) when compared to N2O-oxygen (28.4 +/- 5.7 and 9.5 +/- 1.6 cm H2O, P < 0.01) and nitrogen-oxygen (28.0 +/- 4.4 and 10.6 +/- 1.3 cm H2O, P < 0.01).     

Comparative Ventricular Electrophysiologic Effect of Racemic Bupivacaine, Levobupivacaine, and Ropivacaine on the Isolated Rabbit Heart

Background: Numerous local anesthetics have an asymmetric tetrahedron carbon, which confers stereoselective differences between the isomers. The authors attempted to quantify the depressant effect of racemic bupivacaine, levobupivacaine, and ropivacaine on myocardial ventricular conduction and on myocardial contractility.

Methods: The authors studied the pharmacokinetics (outflow concentration) and pharmacodynamics (QRS widening) of the three drugs infused in an isolated rabbit heart preparation. All data were fitted simultaneously with use of mixed-effect modeling, thus allowing precise statistical comparison between the three drug parameters. The rate dependence of QRS widening was fitted separately.

Results: Racemic bupivacaine, levobupivacaine, and ropivacaine induced a calculated maximum increase in QRS duration in the ratio 1:0.4:0.3. Css50, the dose which caused half the maximum increase in QRS duration at steady state, was similar for all three drugs (22 [mu]m free concentration). A rate dependence of QRS widening was observed, which was in the ratio 1:0.5:0.25 for racemic bupivacaine, levobupivacaine, and ropivacaine, respectively.     

孤立性左室舒张功能障碍患者心脏细小病毒B19感染率较高

背景:目前,孤立性左室舒张功能障碍的病原学仍不清楚。本文报道了细小病毒B19(PVB19)基因组与孤立性左室舒张功能障碍高度相关。方法与结果:研究纳入了70例住院患者(年龄43±11岁),这些患者尽管左室收缩功能保留(射血分数为68%),但存在运动性呼吸困难和(或)运动耐力下降的表现,而临床疑似为孤立性左室舒张功能障碍。具有诸如高血压、冠心病、糖尿病及肺部疾病的典型舒张功能障碍危险因素的患者除外。通过超声心动图及左、右心室导管术评估舒张功能。行心内膜心肌活检(EMB)分析是否存在贮积或浸润性疾病或心肌炎,包括对嗜心肌病毒基因组的…     

环孢霉素A致面部弥漫性皮脂腺增生

背景:许多接受环孢霉素A治疗的患者都被报道发生了皮肤并发症。毛皮脂腺囊的改变尤其多见(如多毛症、毛囊角化病、痤疮和毛囊炎),而皮脂腺增生则较罕见。方法:1例27岁的男性患者因面部出现小乳头状皮疹而于2003-02接受会诊。患者于1993年接受肾移植后使用了环孢霉素A和强的松,其面颊、前额和鬓角同时出现皮损。组织学检查确诊为皮脂腺增生。异维甲酸治疗1月之后皮肤状况获得一定改善。讨论:大约10%接受环孢霉素A治疗的患者会发生皮质腺增生,此副作用仅发生于40岁左右的男性。往往会发现皮脂腺增大,但是增多则较为少见。作者报道的病例为1…     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

荧光原位杂交技术在急性髓系白血病诊断中的应用

目的探讨荧光原位杂交技术（FISH）在急性髓系白血病（AML）的诊断中的意义。方法对初发的经骨髓常规形态学、细胞化学染色和免疫分型初步诊断的10例AML-M2、19例AML-M3，11例AML不能确定为M2或者M3的患者，进行FISH技术检测AML1／ETO和／或PML／RARα融合基因，进而协助诊断和指导治疗。结果10例AML-M2中AML1／ETO融合基因阳性率40％（4／10）；19例AML-M3中PML／RARα融合基因阳性率89％（17／19），1例AML1／ETO融合基因阳性，确诊为AML-M2；11例AML中AML1／ETO融合基因阳性率18％（2／11），PML／RARα融合基因阳性率45％（5／11），其余4例未检测到以上两种融合基因。结论FISH是一种敏感的分子遗传学的新技术，具有高效、快速、灵敏等优点。对AML的诊断分型具有重要帮助，进一步指导临床治疗。     

5-氨基水杨酸治疗溃疡性结肠炎多中心临床观察

溃疡性结肠炎 (ｕｌｃｅｒａｔｉｖｅｃｏｌｉｔｉｓ,ＵＣ)病因尚未完全明确 ,病程迁延 ,治疗缺乏特异措施 ,且有癌变危胁。本研究旨在探讨 5 氨基水杨酸 (5 ＡＳＡ ,商品名 :艾迪莎 ,Ｅｔｉａｓａ ,法国博福 益普生制药公司 )对比柳氮磺胺吡啶 (ｓａｌｉｃｙｌａｚｏｓｕｌ ｆａｐｙｒｉｄｉｎｅ,ＳＡＳＰ)治疗ＵＣ的临床疗效。一、材料与方法ＵＣ诊断按 1993年太原全国慢性非感染性肠道疾病学术研讨会标准 ,参照美、英临床试验报道质量标准[1,2 ] 。由 6家医院多中心、随机数字表法纳入轻、中度ＵＣ 116例 ,其中ＳＡＳＰ对照组 6 0例 ,…