可吸收钉治疗后交叉韧带损伤

2002年8月-2005年8月，我科采用膝后侧入路，用可吸收钉治疗后交叉韧带损伤15例，效果满意，报道如下。     

脊髓损伤犬模型的建立及激光多普勒血流测定仪评价的意义

目的：探讨激光多普勒血流测定仪（LDF）在建立的急性犬脊髓损伤模型中的评价作用。方法将15只比格犬分为A、B、C组。通过改良的脊髓损伤数控装置,采用不同的撞击和压迫时间,建立不同的急性脊髓损伤犬模型。A组为1．2m／s＋5 mm＋5 mm＋15 mns ,B组为1．2 m／s＋5 mm＋5 mm＋10 mns ,C组为对照组。应用LDF分别测量3组脊髓损伤模型的脊髓血流（SCBF）图,通过脊髓坏死面积测量评估两组模型犬的病理学改变。结果 LDF测量3组脊髓损伤模型的SCBF图结果显示, A组模型SCBF量降低最明显,A组损伤程度明显重于B、C组,差异有统计学意义（P＜0．05）。运动诱发电位显示,SCBF的下降程度与预后及运动功能密切相关。结论通过LDF可有效判断急性脊髓损伤的程度和SCBF的情况,在动物实验和临床领域有较好的应用前景。     

早期运动训练联合神经干细胞移植对脊髓损伤模型大鼠后肢运动功能的影响

BACKGROUND: Studies have shown that neural stem cell transplantation combined with exercise training can promote the recovery of hindlimb motor function from spinal cord injury in rats, but its mechanism of action has not been fully elucidated. OBJECTIVE: To investigate the effects of early exercise training combined with neural stem cell transplantation on the recovery of hindlimb motor function in rats with spinal cord injury. METHODS: Sixty Sprague-Dawley rats with spinal cord injury were randomly divided into three groups: control group (n=20, given conventional treatment after injury), cell transplantation group (n=20, given neural stem cell transplantation after injury), experimental group, (n=20, given neural stem cell transplantation combined with early exercise training after injury). Recovery of the hindlimb motor function was assessed by Basso, Beattie and Bresnahan scale and inclined plane test before and at 1, 7, 14, 21 days after injury. Western blot assay was used to detect caspase-3 and myeloperoxidase expression. Hematoxylin-eosin staining was done at 21 days after injury to observe the structure changes of the injured spinal cord. RESULTS AND CONCLUSION: (1) Scores of Basso, Beattie and Bresnahan scale and inclined plane test were significantly better in the experimental group than the cell transplantation group followed by the control group (P < 0.05). (2) In the control group, the expression of caspase-3 and myeloperoxidase was significantly increased at 14 days after injury. In the cell transplantation, the expression of caspase-3 and myeloperoxidase was significantly higher than the experimental group (P < 0.05). (3) Pathological inflammation was reduced most in the experimental group followed by the cell transplantation group. In the experimental group, the structure of injured spinal cord was improved and became relatively clear and intact. These findings indicate that neural stem cell transplantation combined with early exercise training can effectively promote the recovery of hindlimb motor function from spinal cord injury in rats, by reducing the expression of caspase-3 and myeloperoxidase and alleviating secondary lesion of the spinal cord.      

骨折钢板内固定不愈合影响因素分析

本文综述了骨折钢板内固定不愈合原因及其影响因素,指出骨折手术需具备的条件及其预后.尽量避免医源性因素损害,明确骨折部位、性质与钢板内固定物的力学关系,可取得良好效果.