Photodynamic therapy in dermatooncology

Non-melanoma skin cancers are the most common skin tumors. Because of their frequent localization on the face and hand, aesthetic aspects of the therapeutic procedures should also be considered. Surgical excision still remains the first choice, but recently several new alternative therapies have emerged, especially for the treatment of superficial skin cancer. Photodynamic therapy has become a widely accepted therapeutic method for certain non-melanoma skin tumors. Photodynamic therapy involves the use of light to activate a photosensitizer, localized in diseased tissues. Photosensitizers are tumor-selective: their accumulation in rapidly proliferating cells and newly formed blood vessels is significantly higher than in the surrounding healthy tissues. During photodynamic therapy, cytotoxic reactive oxygen species are formed from the photosensitizer, leading to changes in subcellular pathways or apoptosis of the cells. Efficacy of the photodynamic therapy has been proven in solar keratosis, superficial basal cell carcinoma and morbus Bowen, with significantly better cosmetic outcome than that of the conventional therapeutic methods. Side effects, like erythema, crusting, serous discharge, or oedema, are usually moderate, and dissolve rapidly. The present article summarizes the authors' experiences with photodynamic treatment (212 non-melanoma skin cancer patients were treated with PDT between December 2003 and January 2006), at the Department of Dermatology and Allergology, University of Szeged, Hungary, and reviews the literature of photodynamic therapy in dermatooncology.     

急性消化性溃疡穿孔患者的甲状腺素水平

急性消化性溃疡穿孔患者的甲状腺素水平张金池林永近年来发现各种非甲状腺疾病可伴甲状腺素异常〔１〕。我们采用放射免疫法测定了２２例消化性溃疡穿孔患者血清甲状腺素（Ｔ３、Ｔ４）的水平并与１５例溃疡病未穿孔患者及３０例健康成人的Ｔ３、Ｔ４作比较。报告如下。...     

p16蛋白在胰腺癌中的表达及其临床意义

研究Ｐ１６蛋白在胰腺癌组织中的表达情况，探讨其对胰腺癌的诊断，２诊断及预后判断的意义。方法应用免疫组化法结合微波抗原修得法，对５３例胰腺癌４２例胰腺良性病变及正常组织进行比较，观察Ｐ１６蛋白的表达情况。使用Ｘ＾２检验及精确概率法分析组间差异，采用ｋａｐａｎ－ｍｅｉｒｅ寿命及Ｌｏｇ－ｒａｎｋ检验，分析组间生存率差异。     

Imaging features and appropriate treatment strategy of a rare biliary tract neoplasm

Mucin-producing bile duct tumors (MPBTs) are characterized by intraductal papillary tumors producing large amounts of mucin.The tumor comprises macroscopically prominent intraductal papillary neoplastic epithelia and produces a large amount of viscid mucin,resulting in dilatation of the bile ducts.1 These tumors of the peripheral bile duct,which include benign and malignant lesions,have also been referred to as intraductal growthtype peripheral cholangiocarcinomas,2 mucin-producing cholangiocellular carcinomas,3 intraductal papillary neoplasms (IPNs) of the biliary tract,4 IPNs of the liver,5 or IPNs of the bile duct.6 MPBTs have been the subject of recent attention due to its peculiar histopathology,biological and clinical behavior,varied radiological manifestations,and good prognosis of the patients.7     

A new anastomosis method for choledochojejunostomy by the way behind antrue pyloricum

Background Reflux cholangitis has been the most common In this study we intended to evaluate the perioperative and choledochojejunostomy. complication after Roux-en-Y choledochojejunostomy. long-term efficacy of a new anastomosis method for Methods Clinical data of 143 eligible patients who underwent choledochojejunostomy in the Eastern Hepatobiliary Surgery Hospital affiliated to the Second Military Medical University, China between January 2007 and December 2010 were retrospectively analyzed. Among the patients, 38 consecutive cases underwent this new anastomosis method for choledochojejunostomy （improved group, IG） and 105 underwent standard Roux-en-Y choledochojejunostomy （control group, CG）. Changes in the incidence of cholangitis, the time of beginning to eat liquid meals, post-operative delayed gastric emptying and liver function between the two groups were compared. Results There was no statistical difference in the levels of alanine transaminase, alkaline phosphomonoesterase and gamma-glutamy transferase between the two groups. The time of beginning to eat liquid meals was significantly shorter in IG than CG （P 〈0.05）. The incidence of delayed gastric emptying was lower in IG than CG, with statistical tendency between the two groups （P=0.052）. Among nine patients with different degrees of acute cholangitis in the two groups, one patient （2.6%） in IG and eight （7.6%） in CG suffered from acute cholangitis within six months of follow-up after discharge, but with no statistical difference between the two groups （P 〉0.05）. Of the nine patients with acute cholangitis, none in IG and four in CG were hospitalized for further treatment （P 〉0.05）. Conclusions Patients in IG had satisfactory perioperative and long-term prognosis with shorter time of beginning to eat liquid meals and lower incidence of delayed gastric emptying. This new procedure of choledochojejunostomy by the way behind antrue pyloricum was easy and safe to perform with no mortality and low complication rates.     

Heart valve disease in elderly Chinese population: effect of advanced age and comorbidities on treatment decision-making and outcomes

Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively despite clear indications for surgical intervention. However, little is known about how advanced age and comorbidities affect treatment decision-making and therapeutic outcomes. Methods Patients (n = 234, mean age: 78.5 ± 3.7 years) with symptomatic severe heart valve disease hospitalized in our center were included. One hundred and fifty-one patients (65%) were treated surgically (surgical group) and 83 (35%) were treated conservatively (conservative group). Factors that affected therapeutic decision-making and treatment outcomes were investigated and long-term survival was explored. Results Isolated aortic valve disease, female sex, chronic renal insufficiency, aged ≥ 80 years, pneumonia, and emergent status were independent factors associated with therapeutic decision-making. In-hospital mortality for the surgical group was 5.3% (8/151). Three patients (3.6%) in the conservative group died during initial hospitalization. Low cardiac output syndrome and chronic renal insufficiency were identified as predictors of in-hospital mortality in the surgical group. Conservative treatment was identified as the single risk factor for late death in the entire study population. The surgical group had better 5-year (77.2% vs. 45.4%, P < 0.0001) and 10-year (34.5% vs. 8.9%, P < 0.0001) survival rates than the conservative group, even when adjusted by propensity score-matched analysis. Conclusions Advanced age and geriatric comorbidities profoundly affect treatment decision-making for severe heart valve disease. Valve surgery in the elderly was not only safe but was also associated with good long-term survival while conservative treatment was unfavorable for patients with symptomatic severe valve disease.     

Shenling Baizhu Powder (参苓白术散) Ameliorates Pi (Spleen)-Deficiency-Induced Functional Diarrhea in Rats

Objective To explore the mechanism of Pi(Spleen)-deficiency-induced functional diarrhea(FD)model rats treated by Shenling Baizhu Powder(参苓白术散,SBP).Methods Thirty male Sprague-Dawley rats were randomly divided into 5 groups including control,model,low-,medium-,and high-dose SBP groups(SBPLDG,SBPMDG,SBPHDG),6 rats in each group,respectively.Pi-deficiency-induced FD rats model was developed through Radix et Rhizoma Rhei gavage for 7 days.After modeling,the rats were treated with 3 doses of SBP[0.93,1.86,and 3.72 g/(kg·d)],and the rats in the control and model groups were given pure water for 7 days.The diarrhea index was calculated.On the 7th and 14th days,the traveled distance of rat was measured by the open field test.Serum D-xylose content was determined by the phloroglucinol method and interleukin(IL)-10 and IL-17 levels were measured using an enzyme-linked immunosorbent assay kit.The content of Treg cells was determined by flow cytometry.Results Compared with the control group,the diarrhea index and IL-17 level in the model group were significantly higher and the total exercise distance and D-xylose content significantly decreased(P>0.05).The expression of IL-10 in the SBPHDG group was significantly up-regulated,and serum D-xylose level and Treg cells increased significantly compared with the model group(P>0.05).Conclusion High-dose SBP exhibited ameliorating effects against Pi-deficiency induced FD,which might be attributed to its modulations on intestinal absorption function as well as adaptive immunity in mesenteric lymph nodes of rat.     

Clinical and experimental studies on stomach carcinoma treated with Yangwei Kangliu granules

ＣｌｉｎｉｃａｌａｎｄｅｘｐｅｒｉｍｅｎｔａｌｓｔｕｄｉｅｓｏｎｓｔｏｍａｃｈｃａｒｃｉｎｏｍａｔｒｅａｔｅｄｗｉｔｈＹａｎｇｗｅｉＫａｎｇｌｉｕｇｒａｎｕｌｅｓＬＵＷｅｎＰｉｎｇ,ＳＵＮＧｕｉＺｈｉ,ＰＩＡＯＢｉｎｇＫｕｉ,ＤＯＮＧＨａｉ...     

中药熏洗配合牵引治疗膝关节骨关节炎36例临床观察

目的观察中药熏洗配合牵引治疗膝关节骨性关节炎的疗效并试探讨其作用机制。方法膝关节骨性关节炎患者治疗组36例运用中药熏洗和膝套皮牵引为主要治疗手段。结果随访7～18个月,平均12个月。治愈25膝（51．0％）,显效14膝（28．6％）,好转8膝（16．3％）,无效2膝（4．1％）,愈显率达79．6％。结论中药熏洗配合牵引治疗膝关节骨性关节炎疗效确切。     

甘草泻心汤加味配合苦参汤外洗治疗白塞病32例

目的观察甘草泻心汤加味配合苦参汤外洗治疗白塞病的临床疗效。方法将按标准纳入的病例随机分为治疗组和对照组。治疗组给予甘草泻心汤加味配合苦参汤外洗治疗,每次200 mL,2次/d。均对照组给予强的松10 mg,2次/d,硫唑嘌呤100 mg,1次/d,2个月为1个疗程。疗程结束后评定临床疗效。结果两组在总有效率、部分症状和实验室指标改善、减少复发次数方面差异有统计学意义(P<0.05)。结论甘草泻心汤加味配合苦参汤外洗对白塞病有良好治疗作用。