市售预包装食品包装标识标注情况调查分析

为了解市售预包装食品包装标识的基本情况,对吉林市68家经销单位销售的693件预包装食品包装标识进行了专项调查。结果显示合格率为75.76%。从标注项目上统计包装标识不合格的主要原因有法条规定须特殊标注的项目不合格;存在夸大或者虚假的宣传内容;生产日期不合格;制造者、经销者的名称和地址不合格;配料表不合格。从食品种类上统计不合格率较高的有保健食品、特殊营养食品、新资源食品、糕点类、冷饮食品和调味品,并对调查结果进行了分析讨论,提出了解决对策。     

硕通镜与软镜治疗输尿管上段结石对照研究

目的 比较分析硕通镜碎石术与输尿管软镜碎石术治疗10mm<直径≤20mm的输尿管上段结石的临床应用效果。方法 选取2018年7月～2019年12月输尿管上段结石10mm<直径≤20mm的患者115例作为研究对象,随机选择其中的55例采用硕通镜碎石术进行治疗(观察组),另外的60例采用输尿管软镜碎石术治疗(对照组),比较观察两组患者的手术相关指标,其中包括手术时间、术后住院天数、术后1天及术后1个月清石率、术后并发症发生率等指标的差异,同时记录两组患者术后辅助治疗的情况。结果 两组手术均成功完成,在手术时间方面,两组差异无统计学意义(40.52±10.19min vs 41.01±9.20min,P>0.05);在术后住院天数方面,两组差异无统计学意义(4.04±1.72天vs 4.12±1.67天,P>0.05);观察组术后1天结石清除率较对照组高(94.5%vs 80.0%),差异有统计学意义(P<0.05);两组术后1个月结石清除率差异无统计学意义(96.3%vs 96.6%,P>0.05);观察组术后总并发症发生率低于对照组(5.45%vs 1...     

尿激酶治疗急性脑梗死的临床对照研究

目的探讨尿激酶静脉溶栓治疗急性脑梗死(ACI)的适宜剂量和治疗窗掌握的可行性参考指标.方法对312例ACI患者按不同的临床亚型、治疗窗及CT所见分组.观察同一时窗不同剂量;同一剂量不同的时窗、亚型及有无显示责任梗死灶各组的疗效和出血性转化的相对危险度(RR).结果5万U组疗效明显劣于≥10万U各组(P＜0.01);10、25、50、100万U组间疗效差异无显著性(P＞0.05).全前循环梗死(TACI)亚型患者治疗窗为3～6小时和6～12小时组的疗效明显劣于＜3小时组(P＜0.05),且继发出血性梗死(血肿型)的RR分别为＜3小时组的5.1倍和8.4倍.在6～72小时窗段的部分前循环梗死(PACI)患者中,脑CT尚未显示责任梗死灶组的疗效明显优于已显示组(P＜0.01).结论尿激酶静脉溶栓的适宜剂量为10～50万U,治疗窗的掌握应亚型化和个体化,CT尚未显示责任梗死灶是时窗扩延的重要参考指标.     

先天性马蹄内翻足动物模型胚胎后肢(芽)评分系统的建立

Objective Quantification of the severity of congenital clubfoot is essential for its re-search and treatment. Up to date, no scoring system is available for hind limb bud development. In this study,a scoring system was established based on a murine model Methods Sixty female Wistar rats weighing 220～250 g were randomized into the six control groups and six experimental groups. Vaginal sperm plug detection day was considered to be day 0 of gestation. Hind limb buds from fetuses of E13, 14, 15,16,17 and 18 days were removed and processed. Results Morphogenetic differentiation changes were detected in the experimental groups. According the new scoring system, clubfoot-like deformity was present in 80.9% of the experimental fetuses. We were able to quantify the extent morphogenetic diffcrentiation of the hind limb accordingly. Conclusions Congenital clubfoot deformities begin at early developmental stage and become exaggerated as the fetuses mature. The scoring system can quantify the extent of congenital clubfoot deformity and facilitate its management.     

腔内介入治疗在下肢动脉硬化闭塞症中的应用

目的评价腔内介入治疗在下肢动脉硬化闭塞症中的应用价值。方法回顾性分析本院2006年3月至2009年9月腔内介入治疗的90例下肢动脉硬化闭塞症患者的临床资料,并随访其疗效。结果全组手术成功率94.4%(85/90),与治疗前比较,踝/肱指数平均升高0.22±0.15,差异有统计学意义(P0.05)。随访时间3～36个月,随访率96.7%(87/90),术后3、6、12、30月分别有1例、2例、6例、4例复发,其中10例行二次介入手术后好转;3例行截肢/足手术,其中膝上截肢1例,膝下截肢1例,跖骨截除1例。随访期截肢率3.3%(3/90),死亡率为3.3%(3/90)。结论腔内治疗下肢动脉硬化闭塞症创伤小、恢复快,可重复操作,近期疗效满意,远期疗效尚待进一步观察。     

The effects of β-NGF controlled delivery system on growth of primary cultured chick embryo dorsal root ganglion axons

Objective To construct β-NGF controlled delivery system and evaluate the biological effects of β-NGF on the growth of chick embryo dorsal root ganglion (DRG) axons in vitro. Methods Delivery systems releasing β-NGF at 50/μL, 100/μg/L and 250 μg/L concentration were constructed. To determine the optimal dose response effects of NGF in the controlled delivery system, DRG were co-cultured with of β-NGF at above concentrations while using DRG basic culture as control. Axonal growth was observed. DRG were also cocultured with the components in the controlled delivery system to detect the effects on growth of DRG axons. The experiment was divided into 5 experimental groups and 1 control group: control group, DRG+ fibrin; Group A,DRG+ fibrin+ peptide + heparin + 100 μg/L β-NGF; Group B, DRG + fibrin + heparin + 100/μg/L β-NGF;Group C, DRG + fibrin + peptide + 100 μg/L β-NGF; Group D, DRG + fibrin + 100 μg/L β-NGF; Group E,DRG + fibrin + peptide + heparin. Results The growth of DRG axons in 50 μg/L, 100μg/L and 250/μg/Lconcentration of β-NGF controlled delivery system was 1.31 ( P > 0. 05), 3.78 ( P < 0. 01 ) and 3.05 ( P <0.01) folds of the control respectively. The growth of DRG axons in 100 μg/L group was significantly better comparing to that in 250 μg/L group. The growth of DRG axons in Groups A, B, C, D and E was 3.75, 1.15,1.12, 1.10 and 1.09 folds of the control group, respectively. The difference was only statistically significant between Group A and the control group ( P < 0. 01 ). Conclusion β-NGF released from the β-NGF controlled delivery system was bioactive. It could promote the growth of DRG axons.     

立体定向手术治疗高血压脑出血(附239例报道)

目的探讨超早期立体定向手术治疗高血压脑出血的疗效。方法对239例高血压脑出血分成超早期组(106例)和早期组(133例)施行立体定向脑内血肿排空术,比较两组疗效。结果超早期组术后死亡12例,GOS恢复良好19例,中残61例,重残14例,植物生存0例。早期组术后死亡16例,按GOS恢复良好12例,中残58例,占约49.57%,重残43例,植物生存4例。结论超早期手术治疗高血压脑出血能明显提高临床疗效,如条件许可,应尽早实施立体定向手术清除血肿,减轻血肿对脑组织的损害,降低患者的病死率及致残率。     

静脉化疗联合腹腔灌注化疗治疗晚期胃癌29例

 【摘要】　目的　观察多西紫杉醇联合5-氟尿嘧啶（5-Fu）静脉化疗及顺铂（DDP）腹腔灌注化疗配合射频热疗治疗晚期胃癌的疗效及患者不良反应。方法　多西紫杉醇75 mg／m2,第1天;亚叶酸钙200 mg／m2,第1天至第5天;5-Fu 500 mg／m2,持续静脉滴注,第1天至第5天;DDP 75 mg／m2腹腔灌注化疗,第2天;21 d为1个周期,化疗期间所有患者均用射频肿瘤热疗机行腹部热疗,每周2次,每次1 h,腹腔灌注化疗后1 h开始热疗。所有患者均完成2～6个周期治疗,化疗2个周期后评价疗效。结果　29例患者中部分缓解17例,稳定9例,进展3例,总有效率为58.6 %（17／29）。剂量限制性毒性主要表现为骨髓抑制。结论　多西紫杉醇联合5-Fu静脉化疗及DDP腹腔灌注化疗配合射频热疗组成的双途径化疗方案治疗晚期胃癌近期疗效较好,不良反应可耐受。     

南北方半夏居群相互引种的比较研究

 目的同时比较不同居群半夏在南、北方种植的质量,为半夏的选育和引种栽培提供理论依据。方法将采自不同产地的半夏分别随机种植在南方和北方基地,通过收获指数、含水量、总生物碱含量、综合指数等指标进行比较。结果在北方种植的不同居群的半夏在产量、干物质含量、生物碱含量上都好于南方;引自安岳、河北的半夏无论在北方还是南方收获指数和生物碱含量均较高,其次是潜江半夏。总体上,南方半夏引种至北方好于北方引种至南方。结论南方种源半夏引种至北方好于北方种源引种至南方。