汞中毒致周围神经病2例报告

我院收治2例用中药偏方治疗牛皮癣和癫痫而引起多发性周围神经病患者,现报告如下。     

复发性口疮的整体治疗

复发性口疮是口腔黏膜病中最常见的疾病,以青壮年为主,该病的特点是原因不明,反复发作,在口腔黏膜中的任何部位,出现孤立的、圆形或椭圆形溃疡。可单发或多发,初起时局部黏膜充血、发红、出现针状的白色小点,很快发展成溃疡。直径约2-3mm,表面有一层淡黄色的纤维素膜,病人可以灼热痛感,冷热酸甜可使痛疼加重,从发病到溃疡愈合,如果没有继发感     

自组装肽的止血应用

分子自组装作为一种普遍存在于生命体系中的现象,已成为化学、生物学、材料学和医学等多学科研究的交汇点。近年来,肽分子自组装技术的快速发展,使其在组织工程、药物缓释、仿生医学、美容领域、光学和电子产品开发等方面均显示出巨大的应用潜力,尤其自组装肽在脏器、神经与脑部出血创伤救治上的显著疗效,极大地推进行了其在材料科学和临床医学领域的应用。本文将对自组装肽在不同出血创伤模型中的止血效果与性能特点、作用机制、优缺点及其发展趋势做一综述。     

肠造口患者的自我效能及其影响因素

目的调查肠造口患者自我效能水平,分析其影响因素。方法采用造口患者自我效能量表、一般资料和造口相关情况调查表对新疆南北疆5所三级甲等医院的181例肠造口患者进行问卷调查。结果本组肠造口患者自我效能总分为(67.27±13.55)分,自我效能得分分别在18～59岁、60～69岁、70～79岁、80～89岁4个年龄段依次呈现高、低、高、低变化。自我效能得分随造口术后时间的延长呈逐渐增加,术后6个月至1年的增加幅度显著。多元线性回归分析结果显示,年龄、造口术后时间、自理程度是肠造口患者自我效能影响因素(P0.05)。结论肠造口患者的自我效能处于中等偏低水平,在护理工作中须加强对年龄大、造口术后时间短、自理程度低患者的健康指导,提高自我效能水平,从而改善生活质量。     

经阴道彩色多普勒超声诊断宫内少量妊娠残留物的临床研究

目的：探讨经阴道彩超在诊断宫内少量妊娠残留物中的应用价值。方法：50例患者行人工流产、药物流产后经腹超声诊断为宫内未见明显异常,改为经阴道彩超检查。结果：30例宫内少量妊娠残留物（30／50）,11例内膜增厚（11／50）,9例宫腔内血块（9／50）,均经清宫术和病理证实,诊断率100％,两组比较差异有统计学意义（P〈0．01）。结论：经阴道彩超检查对宫内少量妊娠残留物的诊断有较高的诊断价值。     

Effect of γ-ray on metabolic enzyme CYP3A1 in rat liver on multiple levels北大核心CSCD

Aim To explore the effect of γ-ray on the mRNA,protein expression levels and metabolic activity level of the key drug metabolic enzyme CYP3A1 in rat liver. Methods Wistar rats were randomly divided into control group, 24 h post-radiation group and 72 h post-radiation group. The experimental group was exposed to total body irradiation of single 6 Gy γ-ray. Blood was collected from the orbital venous plexus for blood routine examination and biochemical analysis 24 h and 72 h after irradiation, and liver tissue was prepared for quantifying expression of CYP3A1 mRNA and liver-specific microRNA (miR-122-5p) through RT-PCR. The expression level of CYP3A1 protein was analyzed by Western blot, and the metabolic activity level of CYP3A1 detected by the specific substrate midazolam combined with LC-MS method. Results Com¬pared with the control group, the weights of the rats in the radiation group significantly decreased, and the number of white blood cells was markedly reduced. Simultaneously, the activities of alanine aminotrans-ferase and alkaline phosphatase continuously descended, as well as the levels of total bilirubin and bile acid significantly increased, which indicated that the liver may be damaged after radiation. The relative expression of CYP3A1 mRNA continued to increase significantly 24 h and 72 h after irradiation. CYP3A1 protein expression and metabolic activity levels showed an obvious increasing trend 24 h after irradiation, and rose significantly 72 h after irradiation compared with the control group. At the same time, the expression of miR-122-5p in liver of rats in the 24 h and 72 h post-radiation group continued to decrease rapidly compared with the control group. Conclusions γ-ray radiation may arouse damage effect on liver, which leads to the continuous up-regulation of the mRNA and protein expression levels of the capital metabolic enzyme CYP3A1 in liver tissue, as well as the elevation of the metabolic activity level. The regulatory mechanism might be related to miR-122-5p. © 2023 Publication Centre of Anhui Medical University. All rights reserved.     

慢性肾功能衰竭患者的认知干预调查

本文选取2007—09／2008—09期间在我院肾内科住院的慢性肾功能衰竭患者（chronic renal failure,CRF）114例进行认知干预,现报告如下。     

三维彩色多普勒阴道超声对未破裂型输卵管妊娠保守治疗中的监测价值

目的探讨三维彩色多普勒阴遗超声对未破裂型输卵管妊娠保守治疗中的监测价值。方法56例未破裂型榆卵管妊娠患者采用甲氨碟呤（MTX）联合米非司酮或单用MTX进行保守治疗。于用药前,用药后应用三维彩色多普勒阴道超声连续动态观察异位妊娠组织的包块特征,血流分布特点,分析与疗效的关系。结果三维彩色多普勒阴道超声可对异位榆卵管妊娠提早做出准确诊断,协助临床随时掌握病情变化。用CDFI,HD-Flow观察血流情况对指导临床及时采用有效治疗措施具有重要意义。结论三维彩色多普勒阴道超声对未破裂型输卵管妊娠保守治疗的监测具有重要临床价值;在血流监测中,HD-Flow的敏感性优于CDFI。     

杭州市城乡居民高血压危险因素研究

目的 探讨杭州市城乡居民高血压发病主要危险因素，为社区高血压防治工作提供科学依据。方法 采用分层整群随机抽样方法，对城市2个街道和农村2个乡镇15岁及以上居民1070人进行高血压流行病学调查，对高血压危险因素采用非条件Logistic回归分析。结果 筛选出年龄、高血压家族史、体重指数（BMI）、甘油三酯（TG）和尿酸（URIC）等高血压危险因素。结论 肥胖、血脂升高、尿酸增高和遗传等相关因素在高血压发病中起着重要作用。