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不同隔姜灸治时间对慢性浅表性胃炎脾胃虚寒证患者血清中SOD和MDA的影响 总被引:1,自引:1,他引:0
目的:探讨隔姜灸不同灸治时间对慢性浅表性胃炎脾胃虚寒证患者血清中超氧化物歧化酶(superoxide dismutase,SOD)与丙二醛(malondialdehyde,MDA)的影响。方法:将45例浅表性胃炎脾胃虚寒证患者随机分为隔姜灸20 min组(A组)15例、隔姜灸40 min组(B组)15例、雷尼替丁组(C组)15例。治疗组每天隔姜灸1次,10 d为1个疗程,疗程间休息1 d,共治疗2个疗程;对照组服用雷尼替丁每次0.15 g,1 d 2次,连续服药10 d为1个疗程,疗程间休息1 d,共服药2个疗程。于实验治疗前、治疗后分别抽血取血清检测SOD,MDA的含量,以此观察隔姜灸的疗效及对SOD和MDA的影响。结果:①3组的SOD含量:在各组治疗后与其治疗前比较均有显著性差异。B组治疗前后SOD含量的增加,与A,C两组比较均有显著性差异(P<0.05)。②3组的MDA含量:在各组治疗后与其治疗前比较均有显著性差异。但组间比较,各组治疗前后MDA含量没有显著性差异。结论:隔姜灸与雷尼替丁均能使血清中抗氧化酶SOD活性升高而自由基MDA水平降低,且隔姜灸40min提高SOD水平效果显著,明显高于隔姜灸20 min和雷尼替丁对SOD的作用。证明隔姜灸对浅表性胃炎脾胃虚寒证患者氧自由基产生与清除的酶系统具有良性调节作用,隔姜灸治疗浅表性胃炎脾胃虚寒证取效可能与此机制有关。 相似文献
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Objective
To observe the effect of herbal cake-partitioned moxibustion on the expressions of mitogen-activated protein kinase (MEK1/2) and extracellular regulatory protein kinase (ERK1/2) in gastric tissues of rats with spleen deficiency syndrome, and to explore the possible mechanisms of herbal cake-partitioned moxibustion in treating spleen deficiency syndrome.Methods
Sixty Sprague-Dawley (SD) rats were randomly divided into a blank control group (group A), a model group (group B), a ranitidine group (group C), and a herbal cake-partitioned moxibustion group (group D) by random digit, 15 rats in each group. Rat models of spleen deficiency syndrome were made by intragastric administration of 4 °C 200% concentrated Da Huang (Radix et Rhizoma Rhei). After successful modeling, the rats in group C were treated with 25 mg/(kg·bw) ranitidine by intragastric adminstration and rats in group D were treated with herbal cake-partitioned moxibustion at Zusanli (ST 36) and Zhongwan (CV 12), for 8 d. Excepted for rats in group A, all the other rats were treated with indomethacin at 5 mg/(kg·bw) at 8:00 a.m. on the second day after finishing all the intervention and sacrificed 7 h later to isolate the stomach. Histopathological changes of the gastric tissues were observed under light microscope after hematoxylin-eosin (HE) staining. The protein expressions of MEK1/2 and ERK1/2 in the gastric tissues were detected by immunohistochemistry.Results
After intervention, the gastric mucosal injury in group B was significantly severer than that in group A, with large breakage and ablating; the damage of gastric mucosa was decreased in group C compared with group B; the gastric mucosal surface remained relatively complete, and the status of breakage and ablating was significantly improved. After intervention, compared with group A, the protein expressions of MEK1/2 and ERK1/2 in gastric tissues of the other groups were significantly higher (P<0.01). Compared with group B, the protein expressions of MEK1/2 and ERK1/2 in group C and D were significantly higher (all P<0.01). Compared with group C, the protein expressions of MEK1/2 and ERK1/2 in group D were significantly higher (P<0.01).Conclusion
Herbal cake-partitioned moxibustion promotes the repair of gastric mucosa in rats with spleen deficiency syndrome, via improving protein expressions of MEK1/2 and ERK1/2 in gastric tissues, as well as activating MEK/ERK signaling pathway.9.
目的探索背俞穴隔药饼灸对肺癌癌因性疲劳患者疲劳症状及生活质量的影响。方法 2015年1月至2016年12月共纳入符合标准的肺癌癌因性疲劳患者63例,分为对照组、治疗组。对照组29例,根据症状予以相应的对症支持治疗,同时接受肺癌健康教育,其中男18例,女11例,平均年龄(63.4±7.6)岁(51~70岁),病例分期:ⅢA期8例、ⅢB期12例、Ⅳ期9例;治疗组34例,在对照组基础上采用背俞穴隔药饼灸,其中男20例,女14例,平均年龄(62.7±7.0)岁(50~70岁),病例分期:ⅢA期8例、ⅢB期15例、Ⅳ期11例。观察患者治疗前及治疗后疲劳症状及生活质量。结果治疗后,治疗组Piper量表中感觉、情绪、认知、行为及总分均较治疗前有明显降低,且明显低于对照组的各项评分,差异具有统计学意义(P0.05);治疗组FACT-G中生理状态、社会/家庭状况、情感状况、功能状况及总分均较治疗前有升高,且明显高于对照组的各项评分,差异具有统计学意义(P0.05);对照组和治疗组血清IL-6、TNF-α含量均较治疗前有下降,但治疗组血清IL-6、TNF-α含量均明显低于对照组,差异具有统计学意义(P0.05)。结论背俞穴隔药饼灸可以减轻癌因性患者的炎症反应,起到缓解疲劳症状,提高生活质量的效果。 相似文献
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目的:观察不同灸量隔姜灸对脾虚证大鼠血清三叶因子1(TFF1)和粘蛋白5AC(MUC5AC)含量,以及胃黏膜表皮生长因子受体(EGFR)蛋白表达的影响,探讨隔姜灸治疗脾虚证的可能作用机制及量效特征。方法:将75只SPF级Sprague-Dawley(SD)大鼠按随机数字表法分为空白对照组(A组)、模型组(B组)、隔姜灸3壮组(C1组)、隔姜灸6壮组(C2组)和隔姜灸9壮组(C3组),每组15只。除A组外,其余各组大鼠采用200%的大黄浓缩液4℃灌胃制作脾虚证大鼠模型。造模成功后,B组大鼠不予治疗;C1、C2和C3组大鼠分别接受3壮、6壮和9壮隔姜灸足三里和中脘治疗,连续治疗8 d。观察大鼠一般症状评分,采用酶联免疫吸附法(ELISA)检测血清中TFF1和MUC5AC含量;免疫组化法检测胃黏膜EGFR蛋白表达。结果:干预结束后,与A组比较,B组大鼠脾虚症状积分增高,C1、C2和C3组大鼠血清TFF1、MUC5AC含量及胃组织EGFR蛋白表达明显升高(均P0.01);与B组比较,C1、C2和C3组大鼠脾虚症状积分降低,血清TFF1、MUC5AC含量及胃组织EGFR蛋白表达升高(均P0.01);与C1组比较,C2和C3组大鼠脾虚症状积分降低,血清TFF1、MUC5AC含量及胃组织EGFR蛋白表达升高(均P0.01),但C2组与C3组差异无统计学意义(均P0.05)。结论:隔姜灸能改善大鼠脾虚症状,促进脾虚证大鼠胃黏膜的增殖修复,其作用机制可能与提高血清TFF1和MUC5AC含量,激活EGFR蛋白的表达相关,且灸9壮和6壮的疗效优于灸3壮,但灸9壮和灸6壮的效果相当。 相似文献