无甲状腺疾病临床表现、自身抗体阴性、超声检查正常人群的TSH水平:对亚临床甲状腺功能减退诊断的影响

过去数年中,学术界对TSH最佳上限的确定存在较多争议,即是否应将TSH上限从多数实验室仍在使用的4～5.5μIU/ml降至2.5μIu/ml.在总人群中亚临床甲低的发病率约为5%～10%.     

综述:过氧化氢在甲状腺生理与疾病中的作用

H2O2的一般生理作用 一、H2O2与信号转导 自从de Haen及其同事以及Mukherjee等对胰岛素诱导H2O2生成作出开创性研究以来,H2O2作为细胞内信号分子已被广泛接受,尽管在最初有些争议.在脊椎动物的很多系统中,胰岛素和生长因子可以刺激H2O2生成.     

降钙素的临床应用

降钙素(CT)是维持体内钙磷代谢的重要激素，但目前发现CT除参与体内的钙磷代谢外，还有多种潜在的病理生理功能。现就CT的结构、功能以及临床应用综述。     

更加合理规范地使用抗甲状腺药物

抗甲状腺药物治疗Graves病甲状腺功能亢进症(甲亢)后由于甲状腺组织结构保持完好.所以如果治愈可达良好的治疗效果.本文主要讨论了如何正确选择药物治疗的适应证,提高药物治愈的相关因素,停药指标评估等.     

糖尿病足的临床分析

糖尿病足(diaberic foot,DF)是指糖尿病患者踝关节以下部位的溃疡、坏疽、感染.现将1990～2000年元月收治的30例DF患者资料进行总结,报道如下:     

Graves病药物治疗停药复发相关因素分析

Objective To explore the value of thyroid-stimulating antibody(TSAb) and degree of goiter in predicting the outcome of Graves'disease after antithyroid drug treatment. Methods Seventy-one patients with Graves'disease were given antithyroid drugs for (2. 8±1. 4)years and then followed up for(22±6.0)months.Finally,age,gender,thyroid function,TSAb and goiter size at the time of drug withdrawal were compared between the relapsed and relieved groups. TSAb was measured in all patients by using HEK-hTSHR cells. Results Eleven of 71 patients relapsed during the follow-up after drug withdrawal. The relapse rate (42. 9% ,6/14)in patients with positive TSAb was significantly higher than that (8.8%, 5/57) in patient with negative TSAb (X2 = 9.97, P<0.01). The relapse rates in patients with normal size thyroid, Ⅰ degree goiter,Ⅱ degree goiter were 6.25%, 12.2%,35.7% respectively. TSAb activity, positive rate and goiter size of the relapsed patients at the time of drug withdrawal were significantly higher than those of relieved patients (P<0.05 or P<0. 01). Conclusion TSAb activity and goiter size at the time of drug withdrawal are two effective prognostic markers of relapse in Graves' disease treated with antithyroid drugs.     

中华医学会内分泌学分会第二届全国甲状腺专题会议纪要

中华医学会内分泌学分会“第二届全国甲状腺专题会议”于2003年9月17日～20日在陕西西安召开。与会代表300余人，会议共收到征文280篇，其中特邀专题报告6篇，大会发言18篇，书面交流242篇。由德国默克公司邀请的德国洪堡大学医学院的Derwahl教授在卫星会上作了亚临床甲状腺功能减退(甲减)诊断与处理的专题报告。北京协和医院提供了一     

甲亢合并白细胞减少的临床分析

目的 分析甲亢合并白细胞减少的特点、原因,以期更好的指导临床.方法 收集本院2007年门诊及住院Graves甲亢患者216例进行分析.结果 白细胞正常组和白细胞减少组甲状腺功能差异无统计学意义（P〉0.05）.甲亢自身和经ATD治疔两组的白细胞及粒细胞数目分析差异无统计学意义（P〉0.05）.两组升白细胞药物治疗后白细胞及粒细胞数目差异无统计学意义（P〉0.05）.两组组内治疗前后白细胞及粒细胞数目差异有统计学意义（P〈0.05）.结论 甲亢合并自细胞减少的发生与甲亢本身、抗甲状腺药物、感染、贫血等有关.     

七年制医学生临床实习二级定向阶段“双重管理”模式的探索与实践

随着我国经济社会的发展及医学模式的转变,对医学生的临床技能及科研能力提出了更高的要求。建立七年制临床实习医院-导师双重管理机制,有助于加强七年制医学生临床实践能力、科研能力、职业素养的养成与训练,形成理论实践紧密结合,科研临床相互促进的创新培养模式,达到高层次医学人才的培养效果。本文对这一模式进行了探讨,希望为七年制医学生的培养提供借鉴。     

Graves病药物治疗停药复发相关因素分析

Objective To explore the value of thyroid-stimulating antibody(TSAb) and degree of goiter in predicting the outcome of Graves'disease after antithyroid drug treatment. Methods Seventy-one patients with Graves'disease were given antithyroid drugs for (2. 8±1. 4)years and then followed up for(22±6.0)months.Finally,age,gender,thyroid function,TSAb and goiter size at the time of drug withdrawal were compared between the relapsed and relieved groups. TSAb was measured in all patients by using HEK-hTSHR cells. Results Eleven of 71 patients relapsed during the follow-up after drug withdrawal. The relapse rate (42. 9% ,6/14)in patients with positive TSAb was significantly higher than that (8.8%, 5/57) in patient with negative TSAb (X2 = 9.97, P<0.01). The relapse rates in patients with normal size thyroid, Ⅰ degree goiter,Ⅱ degree goiter were 6.25%, 12.2%,35.7% respectively. TSAb activity, positive rate and goiter size of the relapsed patients at the time of drug withdrawal were significantly higher than those of relieved patients (P<0.05 or P<0. 01). Conclusion TSAb activity and goiter size at the time of drug withdrawal are two effective prognostic markers of relapse in Graves' disease treated with antithyroid drugs.