Effectiveness and safety of Shexiang Baoxin Pill (MUSKARDIA) in patients with stable coronary artery disease and concomitant diabetes mellitus: a subgroup analysis of a randomized clinical trial

Background: Preliminary studies have indicated that Shexiang Baoxin Pill (MUSKARDIA) has a coronary artery dilation effect and increases the coronary blood flow, relieving the symptoms of angina. This study aimed to evaluate the benefit of MUSKARDIA on patients with stable coronary artery disease (CAD) and diabetes mellitus (DM).Methods: This was a subgroup analysis of a multicenter, randomized, placebo-controlled phase IV trial. CAD patients with a medical history of DM or baseline fasting bloo...     

新沂市1988年～1997年中小学生肠道蠕虫感染调查

肠道蠕虫感染是影响中小学生身体健康的主要疾病,我市自１９８８年以来连续开展驱虫工作,学生肠道蠕虫感染明显下降,现报告如下。１　对象与方法本次调查根据《全国学生常见肠道蠕虫感染综合防治方案（试行）》的要求进行。对象为城区小学１所,中学１所;农村小学１所,中学１所,对４所学校部分学生进行粪检。１９８８年采用生理盐水直接涂片法,１９９２年～１９９７年采用改良加藤氏厚涂片法。２　结果与分析２．１　学生肠道蠕虫感染率逐年下降　通过多年持续投药,我市中小学生肠道蠕虫感染率逐年明显下降,经统计学处理χ２＝１１…     

Effects of kadsurenone on the systemic inflammatory response in rat model of acute pancreatitis

Objective： To study the effects of kadsurenone on inflammatory mediators Platelet-activating factor （PAF）, tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） in rat model of acute pancreatitis（AP）. Methods： SD male rats （104） were randomly divided into sham group （n = 24）, AP group （n = 40） and kadsurenone group （n = 40）. The rats were killed 3, 6, 12 and 24 hours after operation. The serum level of PAF, TNF-α and IL-6 was measured. Results： The serum level of PAF, TNF-α and IL-6 of AP group was significantly increased（P 〈 0.01 ）compared with control group. The serum level of TNF-α got to a peak 6 hours after operation, and the serum IL-6 getting to a peak 12 hours after operation in AP group. After kadsurenone was administered to AP rats, pancreas and lung myeloperoxidase （MPO）, serum amylase activity was reduced. Histology showed a trend toward improvement. The serum level of PAF, TNF-α and IL-6 was significantly decreased （P 〈 0.05）. Conclusion. Kadsurenone can reduce the severity of systemic inflammation in rats with AP and relieve the damage of the pancreas and lung in AP rats. These results suggested that kadsurenone may be useful in the treatment of acute pancreatitis.     

The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome

Objective： To investigate V264M polymorphism of tissue factor pathway inhibitor （TFPI） in patients with acute coronary syndrome （ACS） in Chinese. Methods ： The genotypes of V264M were detected by polymerase chain reaction （PCR） and restriction fragment length polymorphism （PCR-RFLP） in 136 patients with ACS and 106 healthy controls with their plasmal f-TFPI tested by enzyme linked immunosorbent assay （ELISA）. Results： Two genotypes were found in V264M： GG and GA. The distribution frequencies of alleles and genotypes were in accordance with those predicted by Hardy Weinberg equilibrium in the present study （χ2 = 0.437, P 〉 0.05）. Plasma f-TFPI level was lower in A allele bearer than that in non-A allele carriers and higher in ACS than control subjects （P〈0.05）. No relationship was found between ACS and V264M polymorphism （P〉0.05）. Conclusion： The V264M polymorphism may have an impact on the plasma level of free TFPI（f-TFPI）, but it has no relationship with ACS.     

谢广茹从脾胃论治肿瘤经验举要

谢广茹主任认为肿瘤多由脾胃虚弱，邪毒乘虚而入所致，脾胃虚弱是肿瘤发生的主要因素。临证当顾护脾胃，补养胃阴。用药当升清降浊同施，补通兼顾，清化湿热，并多用甘味补益，临证化裁提倡机圆活法，不拘一方一法。     

解毒疏络法对肺癌放疗生活质量影响的临床研究

目的:观察清解毒疏络法对肺癌放疗生活质量的影响。方法:设立单纯放疗组(简称对照组)53例,放疗加解毒疏络法组(以下简称治疗组)55例。以KPS记分、QLQ-C30生活质量调查问卷、LC13肺癌特异量表、6m in步行距离、体重、中医疗效评定标准为指标进行临床疗效观察。结果:治疗组KPS记分、LQ-C30生活质量调查问卷、LC13肺癌特异量表、6m in步行距离、体重、中医疗效优于对照组(P<0.05)。结论:解毒疏络法可一定程度地改善放疗患者的生活质量。     

误诊为中心性浆液性脉络膜视网膜病变的原因分析

目的 分析孔源性视网膜脱离、原田病误诊为中心性浆液性脉络膜视网膜病变（CSC）的原因.方法 2001年1月～2006年10月所遇19例（19只眼）误诊为中心性浆液性脉络膜视网膜病变患者.孔源性视网膜脱离误诊为CSC15例,误诊时间2～40 d.原田病误诊CSC4例,患者均为女性,误诊时间分别为1～5 d.4例患者均为双眼视力突然下降,伴有头痛.结果 15例孔源性视网膜脱离患者明确诊断后,均行视网膜复位术.现随访3个月～5年,视网膜在位 4例原田病患者,给予大剂量糖皮质激素治疗,视力提高,为0.3～0.8.结论 CSC、孔源性视网膜脱离、原田病临床上各有其特有的典型体征,导致孔源性视网膜脱离、原田病误诊的主要原因为眼底病知识掌握不全面、忽略散瞳眼底检查.     

Down syndrome biochemical markers and screening for preeclampsia at first and second trimester: correlation with the week of onset and the severity

OBJECTIVES: To estimate the combined screening performance of first and early second trimester prenatal serum markers for Down syndrome, in screening for the development of preeclampsia, and analyze the correlation among marker levels, week of onset, and severity of the disease. METHODS: A retrospective cohort study was carried out on 32 women with preeclampsia and 3044 controls. Serum samples from these pregnancies were assayed for pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotrophin (hCG), and inhibin-A. A likelihood ratio and the odds of being affected given a positive result (OAPR) of various combinations of markers were calculated and receiver operating characteristic (ROC) curves analysis was performed. RESULTS: In the pregnancies that subsequently developed preeclampsia, first trimester PAPP-A concentration was significantly lower and concentrations of early second trimester inhibin-A and hCG significantly elevated. Levels of early second trimester uE3 and AFP were not significantly altered. We also found that inhibin-A correlates with both onset of the disease and the severity. CONCLUSION: Down syndrome biochemical markers levels are altered in those patients who subsequently developed preeclampsia and may be a useful screening test for preeclampsia. Inhibin-A is the most predictive marker and correlates with the severity of subsequent preeclampsia and inversely with the week of occurrence of preeclampsia.