将循证医学引入新形势下的传染病学教学

循证医学是一种新的医学模式,也是一种新的医学教育模式。面对21世纪新形势下的传染病学教学特点,引入循证医学的理念、原则和方法,形成以问题为中心,变学生被动学习为主动学习的教学模式,帮助医学生掌握自我更新医学知识和临床技能的方法和技巧,将大大提高传染病学教学的效果和医学生的能力。     

痢特灵药疹236例临床分析(摘要)

痢特灵临床应用较广,由它所致药疹逐年上升。现将我院236例住院患者临床资料分析如下:一、病例概况:男95例,女141例。年龄5～70岁。因肠道感染服药者占88.56％。1972年以来我院共收治药疹558例,本病占42.29％,居于首位。二、皮肤症状:所有病例均有风团,并感瘙痒,     

乙型肝炎干扰素治疗的研究进展

就近年来国内外应用干扰素治疗乙型肝炎的研究进展作一综述。     

美洲大蠊提取物黏糖氨酸对肝纤维化模型大鼠的影响及机制

BACKGROUND:Hepatic fibrosis in chronic liver disease can be reversed. Studies have shown that Periplaneta americana extract has anti-fibrosis effect, and has protective effect on the experimental hepatic fibrosis rats. OBJECTIVE:To observe the effect of Periplaneta americana extract sticky sugar amino acid on hepatic fibrosis, and to primarily explore the mechanism of sticky sugar amino acid against hepatic fibrosis. METHODS:Rat models of immune hepatic fibrosis were induced by pig serum and intragastrically administered 0.5, 0.25, 0.10 g/kg sticky sugar amino acid. Four indexes of hepatic fibrosis were detected by radioimmunoassay. Immunohistochemical staining was used to measure transforming growth factor beta 1, tissue inhibitor of metalloproteinase protein expression intensity and positive cell rate, to determine the correlation of different concentrations of sticky sugar amino acid, transformation growth factor beta 1 and tissue inhibitor of metalloproteinase.  RESULTS AND CONCLUSION: (1) The Periplaneta americana extract sticky sugar amino acid reduced the levels of laminin, type III procollagen, type IV collagen and hyaluronidase (P < 0.01) and reduced the expression of transformation growth factor beta 1 and tissue inhibitor of metalloproteinase 1 in liver tissue (P < 0.01). (2) Sticky sugar amino acid concentration and transformation growth factor beta 1 and tissue inhibitor of metalloproteinase 1 protein expression showed a significant negative correlation (| r | > 0.9). (3) Results confirmed that the Periplaneta americana extract sticky sugar amino acid can change the reversal of hepatic fibrosis. Its mechanism of action is associated with expression of transforming growth factor beta 1 and tissue inhibitor of metalloproteinase 1 inhibited by sticky sugar amino acids.     

伤寒患者心肌酶谱改变的临床意义

对６６例伤寒患者做心肌酶谱检测并与２１例菌痢患者的心肌酶进行了对照分析，以探讨伤寒患者心肌酶谱改变情况，结果：门冬酸氨基移换酶（ＡＳＴ）乳酸脱氢酶（ＬＤＨ）以及α羟丁酸脱氢酶（ＨＢＤＨ）均有显著差异，肌酸磷酸激酶（ＣＫ）差异无显著性，结果表明伤寒病人有不同程度的心肌损害。     

头发微量元素含量与婴幼儿佝偻病的临床意义探讨

头发是一种代谢活动很低的蛋白组织,所含微量元素可以反映头发生长期间所摄入的微量元素和代谢状况,所以它可以间接反映某一段时间内微量元素的变动。小儿佝偻病是一种慢性营养性疾病,以缺乏维生素引起体内钙、磷及其它微量元素的缺乏或代