一种新的IFN活性标志——MxA蛋白的研究及其临床应用

ＭｘＡ蛋白是Ｉ型ＩＦＮ诱生的特异性蛋白，本文从ＭｘＡ蛋白的生物学活性，基因表达和抗病毒机制，诱导因素及临床检测应用等方面阐述了该蛋白的研究概况。     

正常和膝外翻情况下胫骨近端内部结构模拟

目的模拟正常和膝外翻时胫骨近端的内部结构。方法采用定量骨重建理论与有限元法相结合,对正常力学环境下胫骨近端的内部结构进行模拟,然后以此结构为初始模型,根据膝外翻情况下胫骨平台压力分布的改变规律,合力的作用点在胫骨外侧平台上,模拟膝外翻后胫骨近端内部结构。结果模拟得到的骨密度分布与真实胫骨进行对比,无论是正常力学环境下还是膝外翻情况下,都与实际非常吻合。结论本研究所采用的方法与载荷的分布方式能够正确地模拟预测胫骨近端内部结构,是进一步研究全膝关节置换术后假体周围骨重建行为的基础。     

股骨滑车发育不良的影像学表现

股骨滑车发育不良由瑞典Brattstrom教授于1964年首先提出,国内外学者在历经20年的研究后,对该病的诊断及治疗方案已经取得了一定成果。近年来,随着MRI技术的不断革新与成熟,学者们对该病的诊断方法又取得了一些新的认识;与此同时,国内尚有部分医生对该疾病的理解常与膝关节其他疾病相混淆。因此,本文旨在对股骨滑车发育不良进行单独的讨论,并对国外相关文献进行回顾。     

NSCLC患者外周血液mRNA表达与生存关系

目的:了解外周血癌胚抗原mRNA(CEA mRNA)和细胞角蛋白19 mRNA(CK19 mRNA)表达与非小细胞肺癌(NSCLC)患者预后的关系.方法:以97例NSCLC患者为对象,检测CEA mRNA和CK19 mRNA应用逆转录-套式-聚合酶链反应技术,比较指标阳性者与阴性者36个月生存情况.结果:指标阴性组尤其是24个月生存例数显著多于阳性组(P<0.01-0.05).结论:检测血液CEA mRNA和CK19 mRNA有助于客观评估NSCLC预后.     

重视医患关系在物理诊断教学中的作用

传统的物理诊断仍然是临床实践的核心内容和重要环节,无论是常见病、多发病还是疑难杂症,病史和体检都是诊疗活动的第一步,是构建疾病诊断要素的基础。     

腰椎4、5间盘纤维环纤维层力学性能的实验研究

测试成人腰椎间盘纤维环纤维层的力学性能。用显微外科技术将纤维环逐层分离,每层纤维平均分成8个测点,每层每测点处按纤维走向切取5个试件,长度l=15~20mm,宽b=1~1.5mm,厚t=0.1~0.5mm。进行拉伸实验测得应力-应变曲线,并给出拟合曲线及方程,得出弹性模量、破坏应变、破坏应力、测点处的力学性能参数和方程。测试结果表明:各测点处,沿径向,由外向内弹性模量皆随层数的增加,不断变小;每层纤维弹性模量由前侧向后侧逐渐变小;破坏应力由外层向内层线性递减;破坏应变外部9层随层数增加略有提高,9层以后基本上为一常数(0.34±0.14)。可见,腰椎间盘纤维环纤维具有特殊的力学性能,与其功能相适应,与腰椎疾病的发生有密切的关系。     

不同周龄悬吊和去势SD大鼠生化指标和胫骨征缩实验研究

目的：通过生化指标和力学实验研究,测定不同周龄SD大鼠血清中钙离子和碱性磷酸酶变化趋势,以及不同周龄大鼠胫骨抗压缩破坏载荷的变化。方法：选用48只清洁级9个月月龄SD大鼠,随机分为正常组、悬吊组、去势组和假手术组,以断头的方式处死实验动物,测定血清钙离子和碱性磷酸酶指标和测量整根胫骨在静载压缩破坏情况下的组间差异。结果：4周后,悬吊组和去势组均能得到较好的骨质疏松模型;随着周龄增加,血清钙、碱性磷酸酶含量和胫骨压缩破坏载荷均迅速降低,然后达到稳定。结论：SD大鼠骨质疏松后,骨量并非一直持续丢失,最后会重新达到一个新的动态平衡。     

合并肺部感染的阿尔茨海默病患者急诊右人工股骨头置换术的麻醉与围术期管理

(1)患者男性,年龄84岁,身高175 cm,体重40 kg。因"外伤后右下肢活动受限2 d"入院。患者平时行走不稳,2 d前在家不慎跌倒,当时无意识丧失,无头痛、恶心、呕吐等症状,活动受限,卧床休息后肢体疼痛及活动受限症状无缓解,就诊于本院神经内科,结合病史、查体及X线检查,请骨科会诊后转入骨科治疗。拟行右人工股骨头...     

Relationship between surgical time and postoperative complications in senile patients with hip fractures

Objective：To elucidate the relationship between surgical time and postoperative complications in senile patients with hip fractures, and try to find out other factors which are related to these complications.Methods： Sixty-two patients, 28 males aged from 65 to 72 years with a mean age of 76.3 years and 34 females aged from 65 to 95 years with a mean age of 78.1 years, who had undergone orthopedic surgery because of hip fractures,were enrolled in a retrospective cohort study. The surgical time and pattern, the type of fracture, preoperative comorbidities, American Society of Anesthesiologists （ASA） score and the volume of blood transfusion during operation were obtained from these patients who were followed up by telephone calls for postoperative complications.All the patients were followed up at least for 1 year and were divided into subgroups according to their clinical characteristics and the results were analyzed by the Statistical Analysis System software.Results：There was no significant difference in the morbidity of postoperative eomplications with the gender,age,surgical time and pattern,or ASA score. There was significant difference in the morbidity of postoperative complications related to preoperative comorbidities and the volume of blood transfusion. There was a significant causality between preoperative comorbidities and postoperative complications. The morbidity of postoperative complications was 1.651 times higher in patients with preoperative comorbidities than those without.Conclusions：There is no relationship between the surgical time and postoperative complications in senile patients who received surgery for hip fracture within 1 year.No correlation is found between the postoperative complications and gender,age,type of fracture, surgical pattern,ASA score and the volume of blood transfusion. Preoperative comorbidities are an independent predictor for postoperative complications.