超声雾化治疗毛细支气管炎临床疗效分析

目的　分析超声雾化拍背吸痰治疗毛细支气管炎临床治疗效果。方法　对诊断符合纳入标准的 80例毛细支气管炎患儿 ,采用随机对照方法分为治疗组与观察组 (每组各 4 0例 ) ,除治疗组给予超声雾化拍背吸痰物理方法进行呼吸道管理 ,两组均常规给予抗感染、应用激素和血管性药物及止咳、平喘等综合治疗。对比两组治疗前、后症状好转及住院时间。结果　毛细支气管炎患儿治疗组在临床症状好转或消失、发热降至正常及住院时间等方面所需天数比对照组明显缩短 ,差异均有显著意义 (P <0 .0 1)。结论　超声雾化及拍背吸痰辅助治疗婴幼儿毛细支气管炎是较为有效的方法     

痹痛灵颗粒对胶原诱导类风湿性关节炎大鼠原代滑膜细胞的影响

[目的]观察痹痛灵颗粒对胶原诱导类风湿性关节炎(CIA)大鼠关节原代滑膜细胞的影响。[方法]通过测量Ⅱ型胶原诱导大鼠类风湿性关节炎模型的足踝体积和关节肿胀评分,并对CIA大鼠原代滑膜细胞增殖能力的检测及滑膜细胞培养上清液IL-1β、TNF-α含量的测定,观察痹痛灵颗粒对滑膜细胞及滑膜细胞培养上清液IL-1β、TNF-α含量的影响。[结果]痹痛灵颗粒高、中剂量组大鼠滑膜细胞增殖小于模型组,与模型组相比有显著性差异;痹痛灵颗粒高、中、低剂量组与雷公藤多苷片组的细胞培养液中IL-1β、TNF-α水平明显低于模型组,有显著差异。[结论]痹痛灵颗粒通过抑制CIA大鼠滑膜细胞病理性增生,降低滑膜细胞培养液中IL-1β、TNF-α水平,对胶原诱导大鼠类风湿性关节炎产生一定的治疗作用。     

可必特雾化治疗小婴儿毛细支气管炎疗效评价

目的 观察毛细支气管炎患儿在常规治疗基础上加用可必特雾化吸入的临床疗效.方法 对76例毛细支气管炎患儿采用随机数字表法分成治疗组和对照组各38例.两组患儿在吸氧、抗病毒、止咳、镇静、普米可令舒(布地奈得混悬液)空气压缩泵压缩雾化吸入等常规治疗基础上,治疗组加用可必特(异丙托溴氨+硫酸沙丁胺醇)雾化吸入,对照组加用万托林(硫酸沙丁胺醇)雾化吸入并对比其疗效.结果 治疗组患儿较对照组患儿在气促、喘息缓解、肺部哮鸣音消失时间及治愈时间有差异,差异有统计学意义(p＜0.05).结论 可必特雾化吸入治疗毛细支气管炎疗效显著.     

可必特雾化治疗小婴儿毛细支气管炎疗效评价

目的观察毛细支气管炎患儿在常规治疗基础上加用可必特雾化吸入的临床疗效。方法对76例毛细支气管炎患儿采用随机数字表法分成治疗组和对照组各38例。两组患儿在吸氧、抗病毒、止咳、镇静、普米可令舒（布地奈得混悬液）空气压缩泵压缩雾化吸入等常规治疗基础上,治疗组加用可必特（异丙托溴氨硫酸沙丁胺醇）雾化吸入,对照组加用万托林（硫酸沙丁胺醇）雾化吸入并对比其疗效。结果治疗组患儿较对照组患儿在气促、喘息缓解、肺部哮鸣音消失时间及治愈时间有差异,差异有统计学意义（p〈0.05）。结论可必特雾化吸入治疗毛细支气管炎疗效显著。     

74例无典型皮疹的手足口病脑炎患儿临床特征分析

目的 分析无典型皮疹的手足口病脑炎患儿临床特征,以指导临床早发现、早诊治,为手足口病的防控提供参考.方法 收集2018年1月-2019年12月在杭州市儿童医院住院的74例确诊手足口病脑炎但无典型皮疹患儿的临床资料,包括流行病学资料、临床表现、实验室检查结果、病原学检测结果等进行回顾性分析.结果 74例患儿发病年龄为(6...     

胆胃同病的治疗体会

临床胃脘疼痛、痞胀 (胃、十二指肠慢性炎症、溃疡等 )的患者 ,兼有胁痛 (胆囊炎、胆石症等 )者甚多。根据笔者近几年所诊治的病例不完全统计 ,以胃病为主者 ,经Ｂ超诊断兼有胆病者占 35 %;以胆病为主者 ,经纤维内镜或Ｘ线钡餐检查兼有慢性胃炎、溃疡病者占 40 %。由此可见 ,胆胃同病临床多见 ,现将诊治体会介绍如下。1　临床特征胆胃同病的主症是上腹部胀、痛。部位多在上腹心窝、上脘 ,及于右胁下 ,有的引及右背、肩部。疼痛性质一般为隐痛、触痛、胀痛 ,发作明显时可出现剧痛、绞痛。疼痛一般无规律性 ,有表现为空腹时痛者 ,进食适量可缓…     

某轨枕厂161名噪声作业工人健康体检结果分析

目的了解某轨枕厂噪声环境作业人员的健康状况,早期发现职业禁忌症与职业病,为噪声作业人员健康监护提供理论依据。方法收集2015年某轨枕厂接噪作业人员161人的健康体检资料进行统计分析。结果161人中,听力损失59人,检出率为36.65%,检出率有随工龄、年龄增长而增长的趋势(P0.05)。血压异常29人,检出率为18.01%,检出率有随工龄、年龄增长而增长的趋势(P0.05)。心电图异常35人,检出率为21.74%,检出率有随年龄增长而增长的趋势(P0.05)。结论职业噪声可造成进行性、永久性听力损失,必须加强职业卫生监管力度,同时也要加强对心脑血管系统疾病的预防。     

丙种球蛋白无反应型川崎病的临床特点和治疗分析

目的 探讨丙种球蛋白无反应型川崎病(Kawasaki disease,KD)的临床特点和治疗,为其预防和治疗提供参考。 方法 回顾性分析2013年2月-2015年2月杭州市儿童医院收治的158例川崎病患儿临床资料。首次用药有效者为敏感组,无效者为无反应组。对比分析2组患儿的临床表现、实验室检查、心血管并发症、预后等资料以及无反应组的再次治疗情况。 结果 丙种球蛋白治疗后,敏感者132例(83.54%),无反应者26例(16.46%)。无反应组患儿冠脉损害发生率显著高于敏感组(61.54%比9.09%);临床表现中无反应组患儿颈部淋巴结肿大、皮疹发病率显著高于敏感组(84.62%比64.39%,88.46%比65.15%);无反应组实验室检查中血小板计数(platelet,PLT)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、丙氨酸转氨酶(alanine aminotransferase,ALT)和肌酸激酶同工酶(creatine kinase isoenzyme MB,CK-MB)显著高于敏感组,血红蛋白(hemoglobin,Hgb)显著低于敏感组,差异有统计学意义(P<0.05)。无反应组26例患儿追加丙种球蛋白治疗、糖皮质激素治疗后热退。随访1年,2组患儿恢复良好。 结论 丙种球蛋白无反应型KD发生率较高,且更易发生冠状动脉损害。颈部触痛性淋巴结肿大(直径>2 cm)、皮疹,血沉、谷丙转氨酶、血小板计数显著升高,血红蛋白降低可能是丙种球蛋白无反应型KD的危险因素。      

儿童大叶性肺炎102例分析

目的了解儿童大叶性肺炎的临床特点。方法回顾分析2009年1月—2009年12月我院呼吸科收治的102例大叶性肺炎患儿的临床资料。结果儿童大叶性肺炎以发热、咳嗽为主要临床症状,入院前病程大部分在1周以上;早期体征不明显,大部分表现为病侧呼吸音减弱,后期主要为湿性啰音;胸片或胸部CT全部可以见到节段或大叶分布的大片状密度增高影。结论儿童大叶性肺炎近年有明显增多,且容易有严重合并症,诊断主要靠胸片、胸腔CT检查;病原菌不易明确,主要是经验用药;预后取决于患儿肺部炎症能否及时控制以及有无严重并发症,其中最多见的是肺不张、肺实变,对这些患儿适时采用支气管肺泡灌洗术,才能达到满意的治疗效果。     

Investigation on serum pertussis toxin antibody levels in children aged 0-14 in Hangzhou北大核心CSCD

Objective To investigate the serum antibody level in children with pertussis in Hangzhou city, and to evaluate the incidence of pertussis in children and the immunization effect of vaccine. Methods A retrospective study was conducted.The pertussis toxin IgG antibody levels in 1 486 children aged 0-14 who received physical exa-mination in Hangzhou Children′s Hospital from January to December 2018 of were collected and analyzed.Serum antibody level ≥30 IU/mL was considered seropositive.The children enrolled were divided into the 0-3-year-old, 4-6-year-old, 7-9-year-old and 10-14-year-old groups; then the children under 3 years old were subdivided into groups of 0-<3 months, 3-<6 months, 6-<9 months, 9-<12 months, 12-<18 months, and 18-≤ 36 months; finally, the children were grouped according to their vaccination times, the pertussis toxin IgG antibody level and the infection rate of pertussis were compared among different groups by Mann-Whitney U, Kruskal-Wallis and χ2 tests. Results The overall positive rate of the pertussis toxin IgG antibody was 23.62% (351/1 486), and the median antibody concentration was 6.60 IU/mL.Among children aged 0-14, the 0-3-year-old children had the highest positive rate of the pertussis toxin IgG antibody and the highest median antibody concentration, which were 24.58% (29/118) and 6.95 IU/mL, respectively.There was no significant difference in the antibody positive rate and the median antibody concentration among different age groups (all P>0.05). Among different subgroups of children aged 0-3, the pertussis toxin IgG antibody positive rate and the median antibody concentration were statistically significant (all P<0.05). It was predicted that the pertussis infection rate in children over 3 years old in Hangzhou was about 45.99%.The patients receiving more than 3 doses of vaccination accounted for 87.48% (1 300/1 486), and their antibody positive rate was 25.46% (331/1 300). After excluding unvaccinated children, the comparison results suggested that there was statistical significance in the antibody positive rate and median antibody concentration among different vaccination groups (χ2=24.467, 67.438, all P<0.001). Conclusions The serum pertussis toxin IgG antibody positive rate in children aged 0-14 in Hangzhou is low, but their predicted pertussis infection rate is higher.Children aged 0-14 are easy to become a main source of infection.Therefore, it is necessary to pay attention to and strengthen the vaccination plan and research, enhance the monitoring of the infection source, and prevent the " recurrence of pertussis" . © 2022 Authors. All rights reserved.