甘精胰岛素联合格列吡嗪治疗2型糖尿病的疗效观察

试验组50例患者每日清晨早餐前口服格列吡嗪控释片,晚上注射甘精胰岛素0.2IU为基准,每3d增加2IU,根据患者的具体情况进行逐步调整,直至FBG≤6.7mmol/L;对照组50例患者每日清晨早餐前口服格列吡嗪,晚上注射优泌林N 0.41IU,根据对患者血糖的检测结果对剂量进行逐步调整,直至FBG≤6.7mmol/L。经过3个月的对比研究发现,试验组和对照组患者血糖均有所下降,幅度没有统计学意义。试验组患者晚间的低血糖率低于对照组;试验组血糖值达标率明显高于对照组。甘精胰岛素联合格列吡嗪治疗2型糖尿病的临床效果明显,值得进行临床推广应用。     

开平市中、小学生服阿苯哒唑驱虫糖防治肠道线虫病效果观察

开平市中、小学生服阿苯哒唑驱虫糖防治肠道线虫病效果观察梁志海，陈伯尧，刘恩，邝会添，梁先进，吴松润，吉喆我们于１９９３年开始，采用广东省寄生虫病防治研究所研制的阿苯哒咐驱虫糖对全市中小学生进行连续三年的集体驱虫，并进行基线调查和跟踪监测驱虫效果。现报...     

输卵管开窗术后肌注MTX预防持续性异位妊娠

采用随机方法对未破裂异位妊娠输卵管开窗术后预防性单次肌注MTX,以对持续性异位妊娠发病率作前瞻性观察。所有患者均于1993年7月～1995年3月在南加利福尼亚大学医学中心行腹腔镜下输卵管线性开窗术。贫血、活动性肝病、肾病、白血病,骨髓异常或对MTX过敏者除外。129例患者参加研究,随机分成预防用药组(61例)和对照组(68例),两组平均年龄、孕次、产次、既往异位妊娠次数无统计学差异。预防用药组术后24h内按1mg/kg肌注MTX,对照组不给药。两组患者均行随访,间隔3天查血β-hCG一次直至测不到(<15mIU/ml)。     

白癜风患者血清中甲状腺素的测定

应用放射免疫分析法(RIA),我们对36例白癜风患者血清中甲状腺素T_3、T_4和促甲状腺素(TSH)进行测定,结果表明部分白癜风患者T_4增高,且活动期患者T_4高于静止期,我们认为甲状腺功能的变化可能与白癜风发病有关。     

男性生殖器疣患者的配偶宫颈结构不良发生率高

性行为与性传播疾病(STD)密切相关,后者被认为是宫颈癌和癌前病变流行病学的危险因素.本文作者对男性生殖器疣患者的配偶中HPV亚临床感染和宫颈结构不良情况进行了研究.病例和方法:以51例男性生殖器疣患者的固定性女性配偶为研究对象,年龄16～49岁(平均24岁),询问一般病史包括避孕措施,常规检查包括一项梅毒血清试验,尿道、宫颈标本涂片染色,阴道分泌     

银屑病皮损内皮细胞上的Fc受体和HLA抗原

已证明IgG 的Fc 受体(FcR)在局部与HLA-DR 抗原密切相关。用培养的脐血管内皮细胞能激活T 淋巴细胞。这种激活受Ⅱ类HLA-DR 抗原限制。为了探讨银屑病皮肤免疫过程中内皮细胞的     

腰痛Ⅰ号方治疗实验性神经根炎的病理学观察

腰痛I号治疗实验性大白鼠神经性根炎的病理组织学改变的结果表明：腰痛I号可使炎症减轻,促进变性神经纤维的恢复,减少胶质细胞和胶质纤维的增多,减轻瘢痕化及瘢痕对周围神经组织的挤压。     

普罗布考预防对比剂肾损害的随机化临床研究

Objective Contrast induced acute kidney injury (CIAKI) is a significant clinical problem. We, therefore, performed a prospective, randomized trial to investigate the role of probueol in the prevention of CIAKI in patients with unstable angina pectoris (UAP) undergoing percutaneous coronary angiography (CAG) and interventions (PCI). Methods We studied 205 patients with UAP, who underwent CAG or PCI prospectively. Patients were randomly assigned to probucol group (n = 102) and control group (n= 103). In the probucol group, the patients received probucol tablets 500 mg b. i. d for 3 days before and after intervcntion. All the patients, after intervention, underwent hydration with intravenous saline at a rate of 1 ml per kilogram of body weight per hour for 12 hours. Results Patients were well-matched with no significant differenced at baseline in majority measured parameters between two groups. CIAKI occurred in 23 of the 205 (11.22%) patients. Multivariate logistic regression was used to identify correlates of CIAKI and clinical data. CIAKI was most strongly associated with Scr≥132.6 μmol/L (OR =21.11,95% CI 1.95-56. 06, P＜0.001), Ccr ＜60 ml/min (OR =4.19, 95%(2/1.94-9.05, P ＜0.001), heart function ＞ class Ⅱ (OR = 6.23, 95% CI 2.73-14.21, P ＜ 0.001), Diabetes (OR = 2.049, 95% CI1.19-5.25, P ＜ 0.001), age ≥ 70 yrs (OR = 3.52, 95% CI 1.66-7.43, P ＜ 0.001), coronary artery calcification shown by CAG (OR =4.29, 95% CI 1.99-9.24, P ＜ 0.001). The rate of CIAKI in probueol groups was slightly lower compared with control group (7.84% vs. 14.56%), without significant difference. The post-procedure mean peak of Scr [(101.62±42. 98) μmol/L vs. (117.67 ～68.77) μmol/L, P =0.047] and the post-procedure increasing Ser from baseline (ASer) [(13.49 ± 19. 61) μmoL/L vs.(22.50 ± 18.31) μmol/L, P =0.001] in the probucol group decreased significantly compared with that of control group. Conclusion Prophylactic treatment with probueol 500 mg b. i. d during periproeedural stage in patients with UAP has preventing role against CIAK1 after cardiac catheterization.     

急性安眠药中毒90例急救分析

目的探讨急性安眠药中毒患者的急救方法,提高急救效果。方法对我科90例急性安眠药中毒病例进行回顾性分析。结果除1例死亡外,其余病例均抢救成功。结论及时抢救是基础,控制药物吸收是关键,拮抗呼吸抑制是重点。     

曲普利啶、雷尼替丁和克拉霉素联合治疗慢性荨麻疹疗效观察

目的观察曲普利啶加雷尼替丁和克拉霉素联合治疗慢性荨麻疹的疗效。方法将门诊确诊为慢性荨麻疹的患者随机分为2组：治疗组76例（口服曲普利啶、雷尼替丁和克拉霉素）和对照组76例（口服曲普利啶）。疗程为四周,停药一周后随诊观察疗效。结果治疗组的治愈率为64．5％,总有效率为94．7％;对照组的治愈率为30．3％,总有效率为84．2％;两组的治愈率和有效率比较有显著性差异。结论口服曲普利啶联合雷尼替丁、克拉霉素治疗慢性荨麻疹效果好,值得临床推广使用。