Association of rs10954213 polymorphisms and haplotype diversity in interferon regulatory factor 5 with systemic lupus erythematosus: A meta-analysis

The rs10954213 polymorphism and the haplotype diversity in interferon regulatory factor 5 (IRF5) play a special role in systemic lupus erythematosus (SLE) but with inconclusive results. We conducted a meta-analysis integrating case-control and haplotype variant studies in multiple ethnic populations to clearly discern the effect of these two variants on SLE. Eleven studies on the relation between rs10954213 polymorpisms in IRF5 and SLE were included and we selected a random effect model to calculate the pooled odds ratios (ORs) and the corresponding 95% confidence interval (95% CI). A total of 6982 cases and 8077 controls were involved in the meta-analysis. The pooled results indicated that A allele was significantly associated with increased risk of SLE as compared with the IRF5 rs10954213 G allele (A vs. G, P<0.00001) in all subjects. The same pattern of the results was also obtained in the European, African American, and Latin American. Asian population had a much lower prevalence of the A allele (49.1%) than any other population studied, and Europeans had the highest frequency of the IRF5 rs10954213 A allele (62.1%). The significant association of increased SLE risk and TCA haplotype was indicated in the contrast of TCA vs. TTA as the pooled OR was 2.14 (P=0.002). The same result was also found in the contrast of TCA vs. TTG as the pooled OR was 1.45 (P=0.004). This meta-analysis suggests that the A allele of rs10954213 and TCA haplotype (rs2004640-rs2070197-rs10954213) in IRF5 is associated with the increased risk of SLE in different ethnic groups, and its prevalence is ethnicity dependent.     

足底及足后跟感觉重建方法的选择

目的探讨足底及足后跟皮肤软组织缺损后感觉重建方法,评价各种方法的疗效。方法 27例足底及足后跟皮肤软组织缺损的患者,采用多种方法修复皮肤软组织缺损并重建感觉,观察患者的创面修复效果及感觉恢复效果。结果 27例足底及足后跟皮肤软组织缺损患者中,除1例皮瓣有少部分皮缘坏死外,其余皮瓣修复均一期愈合。皮瓣在术后或术后1年完全或部分恢复皮瓣痛、温、触觉。结论应该根据足底及足后跟皮肤软组织缺损的部位、大小,采用不同方法重建感觉。     

小剂量静脉注射用人免疫球蛋白治疗6例重症寻常型天疱疮的疗效观察

大剂量静脉注射用人免疫球蛋白（intravenous human γ-globulin,IVIG）治疗寻常型天疱疮（PV）圈内、外均有报道,并且对那些对糖皮质激素有依赖或抵抗的重症PV取得了较理想的疗效。笔者对6例重症PV患者采用小剂量IVIG治疗取得了比较好的效果,现报告如下。     

色汗症2例

例1,男,17岁。因衬衫上有绿色汗渍3个月余,于2004年4月就诊。患者于2003年12月发现运动出汗后衬衫呈绿色,多次观察均出现同样的情况。并发现双足出汗后白色棉袜也呈绿色,但易洗脱。就诊时,双足白色棉袜呈淡绿色,嘱其做运动后,发现白色衬衫上有绿色汗迹。患者既往多汗,无服药史。平时嗜饮“冰红茶”饮料,每日2-3瓶。否认家族中有类似病史及遗传病史患者。无其他特殊饮食史,同学中无类似发病者。     

结节性硬皮病的研究进展

结节性硬皮病是硬皮病的一种罕见亚型,好发于颈部、上肢、肩部、躯干部等部位,表现为在正常皮肤表面或者皮肤硬化区中出现坚实、肤色、类似瘢痕疙瘩样的结节。结节性硬皮病在组织病理学上可与典型的硬皮病或者瘢痕疙瘩相似,也可能同时出现两者的特点。目前无确切的治疗方法。     

先天性梅毒1例

报告1例先天性梅毒。患儿,女,半月龄。患儿出生2小时被发现双手足鳞屑样皮疹,皮损逐渐增多。患儿梅毒快速血浆反应素试验(RPR)1∶4,梅毒螺旋体颗粒凝集试验(TPPA)(+),梅毒螺旋体抗体IgM(+)。其母曾有梅毒感染史,RPR:1∶8。诊断:先天性梅毒。给予青霉素治疗14天后,皮疹全部消退,3个月后复查未见皮疹。     

蛎壳状银屑病1例

临床资料患者男,21岁,战士。因躯干、四肢发生丘疹、斑块,伴痒、痛2周人院。2周前,患者躯干、四肢发生丘疹,渐增多、增大伴疼痛,轻度瘙痒,部分皮损形成长条形或梭形斑块,四肢关节无疼痛,未给予任何治疗。起病前有上呼吸道感染病史,无用药史,家族中无银屑病史,无不洁性交史。     

维生素K引起皮肤不良反应1例

患者女,45岁.双臀部红色斑块10 d,于2010年3月就诊.患者因胆道出血,10 d前肌内注射维生素K1后,局部出现红肿硬结,绕针孔可见大片红斑,触之硬而粗糙,皮温较高,自觉疼痛,伴有灼热感和瘙痒感,其他部位未见皮损,余无不适.在当地诊所给予生理盐水湿敷及抗生素软膏外用无明显效果.     

阴茎增殖性红斑1例

患者男,39岁.阴茎、龟头部红斑、糜烂半年.患者半年前发现阴茎腹侧近系带处无明显诱因出现一直径约0.5 cm的不规则淡红色糜烂面,无瘙痒及疼痛,在外院行包皮环切术时一并切除,术后部分切口愈合不良并在切口附近出现类似红斑及糜烂,外科局部处理后无明显好转,红斑、糜烂面逐渐扩大并蔓延至龟头部,于2010年4月5日来我院就诊.患者平素体健,无其他慢性病病史,否认有外伤史及非婚性接触史,家族史无特殊.     

蛎壳状银屑病1例

临床资料患者男,21岁,战士.因躯干、四肢发生丘疹、斑块,伴痒、痛2周人院.2周前,患者躯干、四肢发生丘疹,渐增多、增大伴疼痛,轻度瘙痒,部分皮损形成长条形或梭形斑块,四肢关节无疼痛,未给予任何治疗.起病前有上呼吸道感染病史,无用药史,家族中无银屑病史,无不洁性交史.