怀牛膝与川牛膝的鉴别及其临床应用的异同

通过对怀牛膝与川牛膝在来泺、性状、显微、功效以及主治等方面的比较鉴别，旨在为中医临床用药和西学中人员学习中医药知识提供参考贵料。     

经皮肾镜穿刺用微创扩张引流套件在腹腔穿刺置管引流中的应用

目的探讨微创扩张引流套件在腹腔穿刺置管引流术中的作用,解决一般穿刺置管法放置的引流管管腔偏小,容易堵塞的问题。方法总结我院2005-2010年腹腔穿刺置管引流的病例46例,其中应用Sedinger法留置中心静脉导管作腹腔引流管者29例（甲组）,应用微创扩张引流套件扩张后留置单腔导尿管作为腹腔引流管者17例（乙组）。比对两种方法在负性事件（包括管道堵塞、出血、腹腔脏器损伤、管周多量渗液）方面的差异。结果应用微创扩张引流套件组管道堵塞率低于应用中心静脉导管组,差异有统计学意义（P〈0.05）。在所统计其他负性事件发生率方面,两组差异无明显统计学意义。结论微创扩张引流套件在腹腔穿刺置管术中引流效果良好,并发症发生率低,在注意操作技巧及腹壁解剖特点的情况下有较高的可行性、安全性及实用性。     

TCRCα-575A/G多态性与原发性肾病综合征的相关性研究

目的探讨T细胞受体保守域α链基因(TCRCα)-575A/G多态性与原发性肾病综合征临床和病理的相关性,从基因水平探讨原发性肾病综合征的发病机制。方法利用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)来鉴定基因型,以检测原发性肾病综合征患者和正常对照组TCRCα-575A/G多态性分布规律。收集一般临床指标和患者的病理资料,进行病例对照研究与临床病理资料分析。结果 2组均检出A、G 2种TCRCα-575A/G等位基因,3种组合基因型AA型、AG型、GG型。2组分布频率无显著性差异。临床资料显示:年龄、性别、血压、血脂、血白蛋白、血肌酐水平中任何基因型的分布频率无显著性差异,AA基因型的原发性肾病综合征患者的蛋白尿水平较AG和GG基因型明显升高(P均<0.05)。病理资料显示:AA基因型在微小病变型肾病患者中有较高的出现频率,与GG+AG基因型比较有显著性差异(P<0.05)。AA基因型和A等位基因的原发性肾病综合征患者治疗有效率明显高于其他基因型(P均<0.05)。结论 TCRCα-575A/G基因多态性与原发性肾病综合征的发病易感性不相关,可能与较重的蛋白尿、微小病变型肾病发病、激素疗效相关。     

Expression and significance of β-catenin and peroxisome proliferator-activated receptor-γ in hepatocellular carcinoma

Objective To investigate the expression and significance of β-catenin and peroxisome prolifera-tot-activated receptor-γ,(PPARγ) in bepatocellular carcinoma. Methods Tissue microarrays were established to detect β-catenin and PPARγ expression in 49 cases of hepatocellular carcinoma,49 cases of adjacent nontumoral liv-er tissue and 6 cases of normal liver tissue. The relationships between PPARγ and β-catenin as well as between PPARγ and clinicopathological parameters were observed. Results The aberrant expression rate of β-catenin was 69.39%,48.98 % and 0 respectively (P=0.001). The positive expression rate of PPARγ was 51.02%,30.61% and 0 respectively (P=0.016). Clinicopathological analysis revealed that the increase of PPARγ expression was not associated with age,tumor size,serum alpha fetoprotein (AFP) levels,tumor embolus of portal vein or inferior vena cava,and HBsAg infection(χ2=0.214,3.201,0.046,3.201,P>0.05 for each),but correlated with differentiation grades(χ2=4.693,P<0.05). Aberrant expression of β-catenin was associated with PPARγ expression(χ2= 5.130,P<0.05). Conclusion Aberrant expression of β-catenin may involve in the liver carcinogenesis. The high expression of PPARγ in hepatocellular carcinoma is significantly correlated with the clinicopathological characteris-tics. Detection of PPARγ is valuable for diagnosing hepatocellular carcinoma,and evaluating malignancy extent and prognosis.     

急性高原缺氧对儿茶酚胺代谢的影响

为了从一个侧面了解神经内分泌系统与急性高原缺氧的关系,我们于1989年6月在喀喇昆仑山边防某部对22名健康男性青年做了平原和进入高原后急性缺氧期尿儿茶酚胺类物质定量测定,并与平原进行了对比分析,现作如下报道:     

甲状腺机能亢进手术中肺水肿1例

甲状腺机能亢进手术中肺水肿１例何坤（广东省深圳市中医院５１８００１）患者女，５８岁，主诉颈部肿块逐渐增大伴消瘦、乏力、食欲亢进、劳累时心悸。门诊检查：Ｔ３：４．０１ｎｇ％，Ｔ４：８３８．５ｎｍｏｌ／Ｌ，ＥＣＧ提示房早、左室肥厚伴心肌损害。诊断为甲亢，...     

动态视频人脸考勤方法研究与实现

研究并实现了利用Gabor滤波器和Fisher线性鉴别分析(FLDA)方法的动态人脸识别考勤系统.系统实现的基本思想是运用Gabor变换提取人脸的局部特征和经过Gabor处理后使得人脸对光照变化不敏感;进一步利用FLDA来降维和隐含地提取最有利于分类的最佳鉴别特征;最后将视频采集的考勤图像与训练库中的图像通过比对,得出识别结果.实验结果表明,利用该方法开发的动态人脸识别考勤系统具有识别率高、实用性好、可靠性强等特点.     

TACE术联合TKI及PD-1单抗综合治疗进展期肝癌的临床疗效及安全性分析

目的 探讨肝动脉化疗栓塞(TACE)联合抗血管生成药(TKI)及程序性死亡受体1(PD-1)单抗综合治疗进展期肝癌的临床疗效及安全性。方法 纳入2019年9月至2021年9月西南医科大学附属医院收治的108例进展期肝癌患者,按治疗方式差异分为TACE+TKI组(n=60)及TACE+TKI+PD-1单抗组(n=48)。回顾性收集两组患者的临床资料,用倾向评分匹配(PSM)控制基线特征,分析PSM后两组患者临床疗效、生存情况,并对两组不良反应发生情况作统计分析。结果 PSM后两组患者临床疗效比较,差异无统计学意义(P>0.05)。截止至2023年3月,TACE+TKI+PD-1单抗组PSM后中位无进展生存期(PFS)、总生存期(OS)分别为9.6个月、17.0个月,长于TACE+TKI组(6.4个月、10.8个月),差异均有统计学意义(P<0.05)。两组PSM后Ⅰ+Ⅱ级、Ⅲ+Ⅳ级不良反应发生率比较,差异均无统计学意义(P>0.05)。结论 进展期肝癌患者应用TACE联合TKI或是TACE联合TKI及PD-1单抗均可获得较佳临床疗效,但后者可延长患者生存期,且不提高不良...     

Expression and significance of β-catenin and peroxisome proliferator-activated receptor-γ in hepatocellular carcinoma

Objective To investigate the expression and significance of β-catenin and peroxisome prolifera-tot-activated receptor-γ,(PPARγ) in bepatocellular carcinoma. Methods Tissue microarrays were established to detect β-catenin and PPARγ expression in 49 cases of hepatocellular carcinoma,49 cases of adjacent nontumoral liv-er tissue and 6 cases of normal liver tissue. The relationships between PPARγ and β-catenin as well as between PPARγ and clinicopathological parameters were observed. Results The aberrant expression rate of β-catenin was 69.39%,48.98 % and 0 respectively (P=0.001). The positive expression rate of PPARγ was 51.02%,30.61% and 0 respectively (P=0.016). Clinicopathological analysis revealed that the increase of PPARγ expression was not associated with age,tumor size,serum alpha fetoprotein (AFP) levels,tumor embolus of portal vein or inferior vena cava,and HBsAg infection(χ2=0.214,3.201,0.046,3.201,P>0.05 for each),but correlated with differentiation grades(χ2=4.693,P<0.05). Aberrant expression of β-catenin was associated with PPARγ expression(χ2= 5.130,P<0.05). Conclusion Aberrant expression of β-catenin may involve in the liver carcinogenesis. The high expression of PPARγ in hepatocellular carcinoma is significantly correlated with the clinicopathological characteris-tics. Detection of PPARγ is valuable for diagnosing hepatocellular carcinoma,and evaluating malignancy extent and prognosis.     

Expression and significance of β-catenin and peroxisome proliferator-activated receptor-γ in hepatocellular carcinoma

Objective To investigate the expression and significance of β-catenin and peroxisome prolifera-tot-activated receptor-γ,(PPARγ) in bepatocellular carcinoma. Methods Tissue microarrays were established to detect β-catenin and PPARγ expression in 49 cases of hepatocellular carcinoma,49 cases of adjacent nontumoral liv-er tissue and 6 cases of normal liver tissue. The relationships between PPARγ and β-catenin as well as between PPARγ and clinicopathological parameters were observed. Results The aberrant expression rate of β-catenin was 69.39%,48.98 % and 0 respectively (P=0.001). The positive expression rate of PPARγ was 51.02%,30.61% and 0 respectively (P=0.016). Clinicopathological analysis revealed that the increase of PPARγ expression was not associated with age,tumor size,serum alpha fetoprotein (AFP) levels,tumor embolus of portal vein or inferior vena cava,and HBsAg infection(χ2=0.214,3.201,0.046,3.201,P>0.05 for each),but correlated with differentiation grades(χ2=4.693,P<0.05). Aberrant expression of β-catenin was associated with PPARγ expression(χ2= 5.130,P<0.05). Conclusion Aberrant expression of β-catenin may involve in the liver carcinogenesis. The high expression of PPARγ in hepatocellular carcinoma is significantly correlated with the clinicopathological characteris-tics. Detection of PPARγ is valuable for diagnosing hepatocellular carcinoma,and evaluating malignancy extent and prognosis.