某中小型制药企业工作场所健康促进干预的效果

目的 评估某制药企业在实施工作场所健康促进综合性干预活动后的效果.方法 采用问卷调查、查阅资料、现场观察、满意度调查和访谈等方式进行效果评估.结果 干预后员工对《中华人民共和国职业病防治法》、职业病预防措施、高血压定义、艾滋病传播途径和高血压、冠心病预防措施的知晓率分别从干预前的72.4％、13.8％、67.5％、45.8％、51.7％提高到97.8％、19.9％、82.3％、94.7％、53.1％.员工生活方式得以改善,干预后吸烟改善率为98.5％,饮酒改善率为70.2％,早餐每周4次以上人员较干预前增加30.6％.综合评估47项指标中,41项符合,5项基本符合,无不符合项.结论 开展工作场所健康促进活动,可全面提升该制药企业职业安全卫生管理工作水平,促进员工的身心健康,所制定的综合性干预措施可行有效.     

高敏C反应蛋白、脂蛋白(a)与心绞痛的关系及通心络干预对其的影响

目的探讨高敏C反应蛋白（hs-CRP）、脂蛋白（a）[Lp（a）]与稳定型和不稳定型心绞痛患者的关系及通心络干预对其的影响。方法选取符合纳入标准的62例不稳定型心绞痛（UA）患者、60例稳定型心绞痛（SA）患者和58例心脏神经症患者（对照组）。并对不稳定型心绞痛患者随机分为常规组（31例）和通心络组（31例）。常规组予西药常规治疗，通心络组加服通心络胶囊，观察常规组和通心络组分别治疗8周后hs-CRP、Lp（a）水平的变化。结果不稳定型心绞痛组血清hs-CRP、Lp（a）的水平明显高于稳定型心绞痛组及对照组（P〈O．01）；稳定型心绞痛组血清hs-CRP、Lp（a）水平均明显高于对照组（P〈0．05）。通心络组治疗后hs-CRP、Lp（a）水平与治疗前比较均有统计学意义（P〈O．05或P〈0．01），且与常规组治疗后比较均有统计学意义（P〈O．05）。结论hs-CRP、Lp（a）与心绞痛密切相关；通心络胶囊能明显降低不稳定型心绞痛患者的hs-CRP、Lp（a）的水平，可能具有一定的增加斑块稳定性的作用。     

中医院护生中医理论、操作技能及带教情况的调查

[目的]对中医院护生的实习情况进行问卷调查,为进一步提高中医院实习护生的中医知识和技能提供依据。[方法]选择2010年—2011年在我院实习的护生63人,采用自行设计问卷进行调查,内容包括中医理论、实践及带教情况,对所得结果进行统计学分析。[结果]本科、专科护生在口服中药指导方面比较差异有统计学意义(P<0.05);中医、西医护生病历书写的中医内容比较差异无统计学意义(P>0.05),护生中医操作技能整体成绩偏低,中、西医护生中药灌肠操作比较差异有统计学意义(P<0.05)。[结论]中医院在对护生培养过程中,应体现中医特色,加强中医理论及操作技能培训,将中医内容纳入带教计划中,制订并实施完整的中西医结合的带教计划及考核程序。     

眼窝再造术

采用游离植皮法、带颞浅血管的前额皮瓣法、带颞浅－耳后血管的耳后皮瓣法和带皮下组织蒂的颞部皮瓣法修复由于外伤或肿瘤摘除眼球术后所致眼窝缺失或挛缩１８例。经１￣５年随访，疗效好，外形改善明显。游离植皮法是一种简单、实用的眼窝再造方法，但常需要较长时间的睑缘粘连术。皮瓣转移法是一种较复杂、更适合于伴有凹陷畸形的眼窝狭窄的矫正方法，但在眼周邻近部位导致继发性瘢痕。临床应用中应根据具体病情选择最佳术式。     

植皮术中透明气囊加压的实验研究

针对传统植皮手术的包扎法不能监测皮片压力和成活情况的弊端,作者设计了一种透明气囊加压法。具有压力均匀相对恒定,可直视监测皮片成活过程便于及时发现处理并发症的优点。经动物实验证实其对皮片成活率及皮面细菌污染率与传统敷料包扎无显著性差异。     

放射线联合p53基因及内皮抑素治疗小鼠前列腺癌皮下移植瘤

Objective To test the hypothesis that p53 gene therapy combined with endostatin can enhance tumor response to radiation therapy of RM-1 mouse xenograft prostate cancer and to investigate its mechanism. Methods A mouse prostate cancer model was established. Then mice with xenograft tumor were randomly divided into group A (control), B (radiation), C (radiation and rAdp53), D (radiation and rh-endostatin) and E (radiation and rAdp53 and rh-endostatin). On day 1, rAdp53 was injected intra-tumorously with 1 × 1010 vp per animal to group C and E. From day 1 to 14, rh-endostatin was given 15 mg/kg intraperitoneally daily to group D and E. On day 4 single fraction of 15 Gy was given to tumors in groups B, C, D and E. Normal saline was injected intra-tumorously or intraperitoneaUy accordingly as control. No treatment was done to group A. Tumor volume was measured daily. Samples were collected on Days 5, 10 and 15. Ki67, CD31, p53 and VEGF were detected by means of immunohistochemistry. Results (1) Radiation alone, radiation combined with intra-tumorous injection of Adp53 and/or intraperitoneal injection of rh-endostatin resulted in tumor growth arrest of RM-1 cells in vivo (P = 0.000). Radiation combined with both rAdp53 and rh-endostatin was the most effective treatment (P < 0.05). (2) All the four treatment groups had a decreased expression of mutant type P53 (P = 0.000). The expression of Ki67 in groups B and C were equal (P 0.05) and increasing (P = 0.000), respectively. Group D had a up-down-up curve (P < 0.05), but group E had a up-down one. On day 5 the expresion of VEGF in group E was the lowest (P < 0.05). An increased expression of MVD compared with the control was shown, and MVD in groups C, D and E were always higher than that in the control (P < 0.05). Conclusions The limitation of radiotherapy could be overcome by combination with beth p53 gene therapy and endostatin on the growth of mouse prostate cancer cell. Radiation, rAdp53 and endostatin have their own role but they can be interacted with each other.     

七里塘镇建设规划的卫生效益剖析

七里塘镇位于合肥市东北郊,1986年由国家建设部和全国爱卫办择定为我国三个小城镇规划建设试点镇之一。规划根据该镇的地形、地貌,因地制宜,统筹兼顾,合理布局,体现出有利生产,方便生活,功能明确,环境优雅的特点,取得了     

右心膈角区团状阴影的X线鉴别诊断

右心膈角区由心脏、肺脏和横膈构成，而构成此区的团状阴影很多。在X线检查中较常遇到。现将几种常见影像综述如下，以供参考。