不同治疗方案对多发性骨髓瘤患者骨病的影响

Objective To explore the difference of effects of two regimens (bortezomib and dexamethasone, BD; and thalidomide and dexamethasone, TD) on bone disease in multiple myeloma(MM).Methods Forty patients with newly diagnosed and refractory or relapsed MM were treated with BD or TD regimens from Dec 2006 to Sep 2008. Bone pain score and X-ray examination were carried out before and after therapy. Serum levels of DKK-1, sRANKL, OPG and TRACP-5b were measured by ELISA before and 3 months after therapy. Results Serum TRACP-5b concentration was significantly decreased in patients received TD regimen (5.94 U/L before therapy vs 4.84 U/L 3 months after therapy ,P ＜ 0.05), and so did for serum DKK-1 concentration in patients responded to BD regimen (35.11 μg/L before vs 32.03 μg/L 3 months after therapy,P ＜0.05) ;for serum concentration of sRANKL in patients responded to BD regimen (1.05 pmol/L before vs 0.67 pmol/L 3 months after therapy, P ＜ 0. 05); and for serum concentration of TRACP-5b in responders to BD regimen (5.57 U/L before therapy vs 4.90 U/L 3 months after therapy ,P ＜0.05). Conclusion Bortezomib lowers levels of serum DKK-1 and RANKL in responders, thus leads to normalization of abnormal bone remodeling through the increase of bone formation and reduction of bone resorption. Thalidomide decreases bone resorption regardless of treatmant response.     

门静脉血流阻断加重梗阻性黄疸大鼠肝细胞损伤

目的 探讨门静脉血流阻断对梗阻性黄疸大鼠肝细胞凋亡的影响.方法 Wistar大鼠60只,分为A组:胆道再通、门静脉周围游离、切除肝尾状叶,90 min后关腹腔;B组:胆道再通、肝尾状叶分流门静脉、余肝门静脉血流阻断90 min、恢复正常门静脉血流、切除肝尾状叶,关腹.术后0 、1、6、24、72 h采集标本,进行组织学...     

从二尖瓣波群评价左室功能的进一步探讨

自超声心动图应用于临床以来,许多作者对二尖瓣的运动规律进行了研究,并利用二尖瓣运动曲线的变化来估价左室功能。还有人利用二尖瓣波群的有关指标计算心输出量,认为有一定价值。     

CD4^＋CD25^＋T细胞：一类新被认识的免疫调节细胞

CD4^ CD25^ T细胞是最近才被认识的一类免疫调节细胞，在胸腺产生，主要发挥抑制性免疫调节功能，表达IL-10mRNA，细胞表面表达IL-2受体α链(CD25)，本身不产生IL-2，但在体内、外增殖需要外源性IL-2，在体外为无能细胞(anergy cell)，CD4^ CD25^ T细胞发挥免疫抑制作用是通过细胞-细胞接触依赖方式而非细胞因子依赖方式，CD4^ CD25^ T细胞在调控自身免疫性疾病的发生、炎症反应和T细胞稳态中发挥重要作用。本文拟对CD4^ CD25^ T细胞的生物学特性及其应用研究的最新进展作一综述。     

病毒感染引起单纯红细胞再生障碍性贫血三例

病毒感染引起单纯红细胞再生障碍性贫血三例贾庆瑞，秦秀云，高亚军，主冠利，孙桂珍，孙培玉我们曾收治２例流行性出血热和１例乙型病毒性肝炎合并单纯红细胞再生障碍性贫血（纯红再障）患者，报告如下。例１：患者女，２６岁。因发热、腰痛及四肢乏力６天就诊。Ｔ３７．...     

股骨下段恶性肿瘤段切除及小腿旋转上移再植术

报道3例股骨下段骨肉瘤,在超剂量氮芥肢体局部灌注治疗3周后,行大腿高位截肢及膝关节离断,将小腿旋转180°,与股骨残端行再植术,以踝关节代替膝关节。经1～5年随访,肿瘤无转移.假肢功能优于股部假肢。     

胸部火器伤的救治

胸部火器伤除冲击渡所致的冲击伤外，多为胸部开放伤。根据致伤物穿透胸壁进入胸腔或纵隔与否，胸部开放伤又分为穿透伤与非穿透伤．穿透伤是战时阵亡的重要原因之一，仅次于头部火器伤而列第二位，因而对胸部火器性穿透伤的救冶应特别重视。