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991.
William Marciel de Souza Gustavo Olszanski Acrani Marilia Farignoli Romeiro Osvaldo Reis Júnior Aline Lavado Tolardo Amanda Araújo Serrão de Andrade João Lídio da Silva Gonçalves Vianez Júnior Daniele Barbosa de Almeida Medeiros Márcio Roberto Teixeira Nunes Luiz Tadeu Moraes Figueiredo 《Archives of virology》2016,161(8):2325-2328
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Paulo CJL Santos Renata AG Soares Diogo BG Santos Raimundo M Nascimento George LLM Coelho José C Nicolau José G Mill José E Krieger Alexandre C Pereira 《BMC medical genetics》2011,12(1):13
Background
Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims of this study were to evaluate the frequencies of CYP2C19 and ABCB1 polymorphisms and to identify the clopidogrel-predicted metabolic phenotypes according to ethnic groups in a sample of individuals representative of a highly admixtured population. 相似文献993.
Denis Martinez Roberto Pacheco da Silva Cristini Klein Cintia Zappe Fiori Daniela Massierer Cristiane Maria Cassol Angelo Jose Gon?alves Bos Miguel Gus 《Sleep & breathing》2012,16(1):89-94
Introduction
Obstructive sleep apnea (OSA) affects up to 30% of the adult population and is a risk factor for coronary artery disease (CAD). The diagnostic process, involving polysomnography, may be complex. Berlin questionnaire (BQ) is a validated and economical screening tool. 相似文献994.
Marcela da Silva Rubio Adriana Maria de Almeida Angelo Berchieri Junior 《Avian pathology》2017,46(6):644-651
Currently there are 2659 Salmonella serovars. The host-specific biovars Salmonella Pullorum and Salmonella Gallinarum cause systemic infections in food-producing and wild birds. Fast diagnosis is crucial to control the dissemination in avian environments. The present work describes the development of a multiplex qPCR in real time using a low-cost DNA dye (SYBr Green) to identify and quantify these biovars. Primers were chosen based on genomic regions of difference (RoD) and optimized to control dimers. Primers pSGP detect both host-specific biovars but not other serovars and pSG and pSP differentiate biovars. Three amplicons showed different melting temperatures (Tm), allowing differentiation. The pSGP amplicon (97?bp) showed Tm of 78°C for both biovars. The pSG amplicon (273?bp) showed a Tm of 86.2°C for S. Gallinarum and pSP amplicon (260?bp) dissociated at 84.8°C for S. Pullorum identification. The multiplex qPCR in real time showed high sensitivity and was capable of quantifying 108–101 CFU of these biovars. 相似文献
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Marco Antonio de Andrade Belo Vando Edésio Soares Luciano Melo de Souza Márcia Ferreira da Rosa Sobreira Daniela Miyasaka Silveira Cassol Sandra Barioni Toma 《Experimental and toxicologic pathology》2012,64(3):155-165
The present study evaluated the hepatoprotective effect of an N-acetyl dl-methionine + choline chloride + caffeine + thiamine hydrochloride + nicotinamide + pyridoxine hydrochloride compound at doses of 0.2, 0.6 and 1.0 mL/kg of b.w., and the assessment was done by the investigation of serum-enzymatic activity, metabolic functions of the liver and histophatological changes in female Wistar rats, which were subjected to experimental intoxication with CCl4. One hundred and nineteen rats were randomly distributed into 17 groups, performing five different treatments, being evaluated seven animals per treatment in four periods: 2, 4, 6 and 8 days after CCl4-induced intoxication. Treated rats with the hepatoprotective medicine (HM) presented a significant reduction in infiltration of inflammatory cells, steatosis, necrosis and liver congestion when compared to non-treated rats (control). Beside these results, the treatment showed a positive effect on circulatory alterations in the intoxicated animals, with reduction of spleen and renal congestion, as well as, promotion of a significant improvement in ALT, AST, LDH, ALP, GGT enzymatic serum activity reduction and in recovering liver function regarding the metabolism of urea, triglycerides and glucose. These findings indicate therapeutic usefulness of the compound when administered at dose 0.6 and 1.0 mL/kg of b.w. in female Wistar rats. 相似文献
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Fátima Karoline Araújo Alves Dultra Adna Conceição Barros Helenemarie Schaer‐Barbosa Andréia Leal Figueiredo Clarissa Araújo Silva Gurgel Eduardo Antônio Gonçalves Ramos Ana Maria da Silva Carvalho Jean Nunes dos Santos 《Journal of oral pathology & medicine》2012,41(1):47-53
J Oral Pathol Med (2012) 41 : 47–53 Objective: The aim of this study was to investigate the presence of CD1a‐positive Langerhans cells and their relationship with E‐cadherin in minor salivary gland tumors. Methods: Twenty‐seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E‐cadherin. Results: A significant difference regarding the mean density of CD1a‐positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied (P = 0.001). No CD1a‐positive cells were detected in most cases (n = 5) of cystic adenoid carcinomas. CD1a‐positive cells were detected in one mucoepidermoid carcinoma case, and six low‐grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a‐positive cells between the three malignant tumors showed no significant difference (P = 0.127). No significant difference was observed in the presence of E‐cadherin between tumors (P = 0.73), but it was detected in 24 cases. Conclusions: The lack of CD1a‐positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E‐cadherin mediates cell adhesion in these tumors although we did not demonstrate significance. 相似文献