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排序方式: 共有281条查询结果,搜索用时 15 毫秒
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D F Du Toit J Heydenrych B Smit E van der Merwe G Louw T Zuurmond D Els A Weideman L Du Toit S Wolfe-Coote 《Journal of surgical oncology》1988,38(1):63-70
Islet cell function was studied in pancreatectomized primates with functioning segmental pancreatic allografts more than 100 days after transplantation. Segmental allograft recipients were immunosuppressed with total lymphoid irradiation (TL1) and cyclosporine (CSA). After 100 days, islet function was assessed, at which stage immunosuppression was terminated. Glucose, insulin, glucagon, and C-peptide response was assessed during intravenous glucose tolerance test (IVGTT) and during arginine and tolbutamide stimulation. In eight normoglycaemic primates in which immunosuppressive treatment had been stopped and with mean graft survival of 145 days, islet stimulation was associated with moderate glucose intolerance, reduced K-values, hypoinsulinaemia, and low C-peptide values. Postmortem findings in all animals intentionally killed revealed severe graft atrophy in the absence of significant rejection. Severe graft atrophy in normoglycaemic primates, together with significantly impaired graft function after segmental pancreatic transplantation compared to normal animals, suggest that transplantation of the whole pancreas may be mandatory if normal or near-normal function is to be achieved. 相似文献
55.
On rare occasions, excessive lipase production by functioning pancreatic acinar cell carcinoma results in subcutaneous and intraosseous fat necrosis. A patient with subcutaneous nodules and osteolytic lesions from metastatic fat necrosis associated with this malignancy is reported. Prompt recognition of the syndrome led to complete resection of the otherwise asymptomatic neoplasm of the exocrine pancreas. 相似文献
56.
Christopher J Martin Paul Taylor Henry WW Potts 《BMC medical informatics and decision making》2008,8(1):49
Background
There is a need for a new cardiovascular disease model that includes a wider range of relevant risk factors, in particular lifestyle factors, to aid targeting of interventions and improve population models of the impact of cardiovascular disease and preventive strategies. The model needs to be applicable to a wider population including different ethnic groups, different countries and to those with and without cardiovascular disease. This paper describes the construction of the Cardiovascular Health Improvement Model that aims to meet these requirements. 相似文献57.
Total intravenous anaesthesia with propofol,alfentanil, and oxygen-air: three different dosage schemes 总被引:1,自引:0,他引:1
Lucia van Leeuwen Wouter W. A. Zuurmond Louis Deen Henk J. H. J. Helmers 《Journal canadien d'anesthésie》1990,37(3):282-286
Three different dosage schemes of propofol infusions combined with a fixed-rate alfentanil infusion were investigated in total intravenous anaesthesia. In 30 premedicated patients, divided at random into three groups, anaesthesia was induced with propofol 2 mg.kg-1 immediately followed by an alfentanil infusion 10 micrograms.kg-1.min-1 as a loading dose which was decreased after ten minutes to a maintenance dose of 1 microgram.kg-1.min-1. Vecuronium bromide 0.1 mg.kg-1 was used as the muscle relaxant. After induction of anaesthesia a propofol infusion 2 mg.kg-1.hr-1 was started in group A, 3 mg.kg-1.hr-1 in group B and 4 mg.kg-1 hr-1 in group C. At signs of light anaesthesia supplementary bolus doses of 20 mg propofol and 1 mg alfentanil were given. The patients' lungs were ventilated with air-oxygen (FIO2 0.35). The mean systolic and diastolic blood pressures showed no statistical significant differences between the three groups. A significant (P less than 0.01) decrease of the mean systolic and diastolic blood pressures was present after induction of anaesthesia and tracheal intubation. Recovery was uneventful in all but one patient, who had ventilatory depression that responded to naloxone (0.2 mg IV). Awareness did not occur in any patient. The only difference between the three groups was the higher number of supplementary bolus doses of propofol and alfentanil needed in group A (P less than 0.01). In total intravenous anaesthesia propofol 3 and 4 mg.kg-1.hr-1 as a maintenance dose combined with a two-step fixed-rate alfentanil infusion provided smooth anaesthesia and uneventful rapid recovery. 相似文献
58.
Rathke cleft cysts: CT, MR imaging, and pathologic features 总被引:1,自引:0,他引:1
The authors retrospectively reviewed the clinical, computed tomography (CT), and magnetic resonance (MR) imaging findings in seven patients with pathologically proved Rathke cleft cysts. All the cysts were located in the anterior sella turcica or the anterior suprasellar cistern. Five cysts had both intra- and suprasellar components, one was entirely intrasellar, and the other was predominantly suprasellar in location. The size of the cysts ranged from 8 to 20 mm. CT scans demonstrated low-density homogeneous lesions in four cases. On MR images of three of these four cases, the cysts had the same intensity as cerebrospinal fluid on T1- and T2-weighted images, while in the fourth case, the cyst was hyperintense on the T1-weighted images. In the remaining three cases, CT showed slight hyperdensity relative to brain parenchyma, suggestive of contrast enhancement. MR showed signal heterogeneity of these lesions with focal components of diminished signal intensity of T2-weighted images. These same foci appeared iso- to slightly hyperintense on T1-weighted images. 相似文献
59.
Papillary endolymphatic sac tumors: CT, MR imaging, and angiographic findings in 20 patients 总被引:6,自引:0,他引:6
60.
WW Blessing LF Arnolda Y-H Yu 《Clinical and experimental pharmacology & physiology》1998,25(6):457-460
1. In conscious rabbits, when alerting stimuli elicit vasoconstriction in the ear vascular bed, there is little or no associated change in cardiac output (CO), as measured by chronically implanted Doppler ultrasonic probes. 2. Local anaesthetic injected around the base of the ear substantially diminished the degree of the vasoconstriction elicited during responses. 3. Our results emphasize that selective cutaneous vasoconstriction, an integral part of the response to alerting stimuli in conscious animals, is part of a patterned redistribution of the CO, organized by the brain. 相似文献