表现为慢性脑内血肿的脑血管畸形诊断与治疗

目的：探索CT表现为慢性脑内血肿的脑血管畸形的诊断和外科治疗。方法：回顾性分析10例CT表现为慢性脑内血肿的脑血管畸形，主要症状表现为癫痫，轻瘫和头痛，所有病例均经CT检查，5例经MRI检查，4例经全脑DSA检查，所有病人均经手术治疗，并取得相应资料。结果：术前6例误诊囊性胶质瘤或肿瘤卒中，术后是诊断均为脑血管畸形伴慢性脑内血肿，全组无死亡，除1例轻瘫外均恢复正常；8例临床和影像学随访5月－6年无异常发现。结论：表现慢性脑内血肿的脑血管畸形易误诊为脑胶质瘤，MRI，DSA检查对确诊和治疗有重要意义。     

立体定向~（32）P内放疗和甲氨喋呤内化疗联合治疗脑深部神经胶质瘤

报道４４例脑深部神经胶质瘤采用ＣＴ导向立体定向技术，用放射性胶体磷酸铬（３２Ｐ）进行瘤内放射治疗，其中３０例联合甲氨蝶呤（ＭＴＸ）瘤内化疗。术后经临床和ＣＴ随访６～４８月，结果：临床症状和体征消失１３例，改善２２例，无效或恶化９例。ＣＴ证实显效４例，有效２７例，微效４例，无变化４例，恶化５例。囊性较实质性效果为好，联合治疗较单纯内放疗效果好。作者认为，此法操作简单，效果确定，特别适用于深部和重要功能区的囊性神经胶质瘤，并对联合作用的机理和并发症进行了讨论。     

Submucosal fibrin glue injection for closure of recurrent tracheoesophageal fistula

We describe a new endoscopic technique for closure of recurrent tracheoesophageal fistula in which fibrin glue is injected into the submucosa of the lateral walls of the fistula until the lumen is occluded. This technique eliminates the possibility of the fibrin glue plug becoming dislodged and aspirated. In addition, our technique is simpler and safer in that it does not require diathermy or laser coagulation to deepithelialize the tract, and thereby eliminates the potential for injury to the esophagus and trachea.     

可溶性CXC趋化因子配体16水平与老年男性急性冠状动脉综合征严重程度的相关性

目的 探讨不同类型冠心病患者血中可溶性CXC趋化因子配体16(CXCL16)的水平,以及与冠心病严重程度的关系.方法 选择老年男性共204名,年龄60～92岁,分为对照组(n=40)、稳定型心绞痛组(SAP)(n =80)和急性冠脉综合征组(ACS)(n =84),检测血清CXCL16、生化指标等.结果与对照组(1.87 mg/L)和SAP(2.01 mg/L)患者相比较,ASC患者血清可溶性CXCL16水平(2.35mg/L)显著增高(P =0.001,0.026);CXCL16与年龄(r=0.152,P=0.038)、高敏C反应蛋白(hsCRP,r =0.270,P＜0.001)呈显著相关;将CXCL16水平四分位间距分为Q1～ Q4组,经年龄和hs-CRP校正后,CXCL16水平越高组中ACS的患病风险越大,Q4组(2.270～8.432 mg/L)的OR(95％CI)为7.91(2.41～21.54),而SAP的患病风险无显著性增加,Q4组的OR(95％ CI)为1.72(0.90～3.18).结论老年男性ACS患者血清CXCL16水平较对照组和SAP患者升高,CXCL16水平与老年男性急性冠脉综合征严重程度相关.     

Redox Polymer–Based Nano‐Objects via Polymerization‐Induced Self‐Assembly

Poly(2,2,6,6‐tetramethylpiperidinyloxy‐4‐yl‐methacrylate) (PTMA) redox polymer–based nano‐objects are synthesized by polymerization‐induced self‐assembly with poly[oligo(ethylene glycol) methyl ether methacrylate] and poly[(4‐methacryloyloxy)‐2,2,6,6‐tetramethylpiperidinium chloride] as hydrophilic macro‐chain transfer agents. These hydrophilic blocks are used in order to stabilize hydrophobic PTMA blocks in aqueous medium. The accordingly obtained spherical nano‐objects are observed via transmission electron microscopy analysis. Cyclic voltammetry measurements indicate that the nature and the length of coronal blocks influence the redox process of the PTMA core blocks. Moreover, these electroactive nano‐objects display low viscosities with a shear‐thinning behavior, making them suitable as cathode‐active materials for aqueous flow‐assisted electrochemical systems.     

典型醛类污染物单独及联合作用对小鼠脾淋巴细胞DNA损伤的离体实验研究

应用单细胞凝胶电泳技术(彗星实验)检测了3种典型醛类污染物对小鼠脾淋巴细胞DNA损伤情况。结果发现3种化合物都引起了小鼠脾淋巴细胞产生彗星现象,并且存在一定的剂量-效应关系。表明此3种醛类化合物均可引起细胞DNA发生断裂     

Changes and analysis of anti‐HBs titres after primary immunization in 1‐ to 16‐year‐old Chinese children: A hospital‐based study

Immunization with the hepatitis B vaccine is the most effective measure to prevent Hepatitis B Virus (HBV) infection. The aim of this study was to investigate the change in antibody levels induced by administration of the hepatitis B vaccine in children aged 1‐16 year old in a large sample sized investigation. HBV markers were determined in 93 326 1‐ to 16‐year‐old hospitalized children who completed primary immunization as infants from south‐west China, Chongqing. Analyses were performed on anti‐HBs titre changes with increasing age, and the revaccination effect was evaluated in children aged 7‐14. The percentage of protective antibody was between 45.29% and 63.33% in all age groups, but was higher in the 1‐, 2‐ and 3‐year‐old groups (90.31%, 83.95% and 71.82%, respectively), and the rate of high‐responder was 5.03%‐10.56%, except in the 1‐year‐old group (23.33%). Additionally, 3.33%‐25.79% of subjects had not seroconverted. There was no significant difference in antibody levels between girls and boys (P > .05). The Geometric Mean Titers in children with confirmed revaccination history were significantly higher than those with unknown or no revaccination history (P < .0001). In conclusion, the overall rate of protective anti‐HBs was 67.10% with consecutive age groups from 1 to 16, it decreased from 90.31% to 45.29% for 1‐ to 8‐year‐old individuals, and interestingly, the rate increased from 45.46% to 63.33% for subjects aged 9‐15. Anti‐HBs titres were significantly improved after revaccination. Booster doses are recommended for those without seroconversion, especially children who live in school with other students or have family members with positive HBsAg.