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991.
992.
本文报道了用导数光谱法测定磷酸丙吡胺的尿药浓度,本方法能消除尿中杂质干扰,测定结果准确。6名受试者交叉口服磷酸丙吡胺缓释片和普通片,测得尿药浓度计算消除速度常数K,排泄速率(Δx/Δt)_(max) 所需时间,证明缓稀片药物排泄慢,药效维持时间长,且缓释片的相对生物利用度与普通片基本相同。 相似文献
993.
Cyclosporine and its metabolites in mother and baby 总被引:3,自引:0,他引:3
R Venkataramanan B Koneru C C Wang G J Burckart S N Caritis T E Starzl 《Transplantation》1988,46(3):468-469
994.
Enema reduction of intussusception by hydrostatic pressure under ultrasound guidance: a report of 377 cases 总被引:10,自引:0,他引:10
Three hundred seventy-seven pediatric intussusception patients were treated by normal saline hydrostatic enema under ultrasound guidance from October 1985 to April 1987. Before reduction, the rate of correct diagnosis by ultrasonography was 100%, and the rate of successful reduction was 95.5% in this group. With this technique there is no risk of x-ray exposure to the patient. The definite criteria for reduction are discussed. Clear echogram was shown during reduction and the ileo-ileo-coli intussusception can be diagnosed. Intestinal perforation, if any, can be accurately recognized at once. This technique is believed to be one of the most promising methods in nonoperative treatment of pediatric intussusception. 相似文献
995.
锌对新生大鼠海马培养神经元生长发育的作用 总被引:13,自引:0,他引:13
采用无血清培养的新生大鼠海马神经细胞,观察锌对脑细胞生长发育的作用。结果表明,锌能促进体外培养海马神经元的神经突起生长,突起数增多;神经元的活存数和神经元胞体的直径和面积增加。用流式细胞术分析证明,神经元总蛋白含量增高。本结果提示,锌对海马神经元的生长发育具有促进作用 相似文献
996.
哒嗪酮酸类化合物的合成及其抗惊活性的研究 总被引:1,自引:0,他引:1
以a-酮戊二酸与水合肼与水合肼为原始原料合成了15个N-(3’-磷酸二乙酯丙基)-1,6-二氢-6-氧-3-哒嗪酰胺类化合物,并对它们进行了最大电休克发作(MES)实验,结果表明其中4个化合物表现出中等强度的抗惊活性。 相似文献
997.
对17例胸部冠状面CT增强扫描的应用价值作了介绍,其中16例获得良好结果,与常规体层摄影相似,能使气管、主支气管完整地显示。轴扫只显示气管的某一层面,故对中心型肺癌的定位准确性不如冠扫。增强冠扫后可使纵隔肺门的血管结构清晰地显影,因此能区分脂肪过多症,囊性或血管性病变而明确诊断。 相似文献
998.
作者曾经体外实验证明,均聚寡脱氧胞嘧啶核苷酸片段(dC14)有抗病毒活性,现继续研究其在体内的作用。不给dC14的对照组小鼠,接种腹水瘤细胞后:100%发病和死亡,潜伏期为6d,存活期11d;给每只小鼠dC14 1.3~3.2 mg,发病率和死亡率降低至20%,疾病潜伏期和存活期推迟。在未经dC14处理的种瘤细胞和淋巴组织与经处理的淋巴组织中,多聚酶链反应(PCR)法都检测到病毒核酸,而正常小鼠中则无此种病毒核酸顺序。研究结果提示,dC14对小鼠SRS腹水瘤的发病和生长有抑制作用。此种抑制作用可能是通过抑制病毒基因的表达来实现的。 相似文献
999.
In order to investigate the role of endothelin-1 during ischemia-reperfusion injury, 80 adult male Wistar rats were subjected to three hours of ischemia and one hour of reperfusion. Animals were evenly divided into eight groups. The rats in group 1 served as the normal control group, while the rats in group 2 received an intravenous infusion of endothelin-1 in a dosage of 0.5 ng/kg/min, group 3 in a dosage of 5 ng/kg/min, and group 4 in a dosage of 50 ng/kg/min. The rats in group 5 were infused with angiotensin II (10 ng/kg/min). The rats in group 6 received an intravenous infusion of 10,000 units of superoxide dismutase and 10,000 units of catalase. Group 7 rats were infused with endothelin-1 (50 ng/kg/min), superoxide dismutase (10,000 units), and catalase (10,000 units). Group 8 rats received an infusion of angiotensin II (10 ng/kg/min), superoxide dismutase (10,000 units) and catalase (10,000 units). The infusions were given during the reperfusion period. After one hour of reperfusion, the gastrocnemius and soleus muscles of the experimental animals were excised and assayed for ischemia-reperfusion injury by measuring triphenyltetrazolium chloride (TTC) reduction. The results showed that the limb activity of the ischemic extremity was 40.33 +/- 2.75% in group 1, 41.62 +/- 4.08% in group 2, 14.42 +/- 3.14% in group 3, 4.43 +/- 1.05% in group 4, 23.81 +/- 3.51% in group 5, 57.23 +/- 4.52% in group 6, 31.79 42- 3.63% in group 7, and 27.39 +/- 3.95% in group 8. Endothelin-1 reduced the limb activity in a dose-dependent manner.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
1000.
C Y Chai W C Wu S Wang C K Su Y F Lin C T Yen J S Kuo M J Wayner 《Brain research bulletin》1992,29(1):15-26
The effects of electrical stimulation and microinjection of sodium glutamate (0.5 M) in the sympathetic pressor areas of the dorsal medulla (DM), ventrolateral medulla (VLM), and parvocellular nucleus (PVC) on the knee jerk, crossed extension, and evoked potential of the L5 ventral root produced by intermittent electrical stimulation were studied in 98 adult cats anesthetized with chloralose and urethane. During electrical and glutamate stimulation of these pressor areas, in addition to the rise of systemic arterial blood pressure marked inhibition of the spinal reflex was produced, indicating presence of neuronal perikarya responsible for these actions. Mild to moderate augmentation of spinal reflexes was also observed during brain stimulation but only in a few cases. The magnitude of the somatic effects among the pressor areas of the VLM, DM, and PVC subsequent to glutamate activation was about the same. Induced spinal reflex inhibition, independent from the baroreceptor and vagal influence, remained essentially unaltered after acute midcollicular decerebration. The inhibition was also observed in cats decerebellated 8-10 days in advance. The inhibition was not affected after bilateral electrolytic- or kainic-acid-induced lesions in the paramedian reticular nucleus (PRN). On the contrary, PRN-induced spinal reflex inhibition was attenuated after bilateral lesions in the DM or VLM. Data suggest that there coexists neuronal subpopulations in the VLM, DM, and PVC that can affect both the sympathetic pressor systems and spinal reflexes. 相似文献