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排序方式: 共有106条查询结果,搜索用时 15 毫秒
51.
Hassan Baydoun George Khoueiry Zahraa Ghandour Yefim Olkovsky 《Heart & lung : the journal of critical care》2014
Right and left heart failure are very common clinical syndromes with close correlation. Right-sided or right ventricular heart failure usually occurs as a result of left-sided failure. We report a very rare case of transition from right heart failure due to pulmonary embolism, followed by its resolution, to left heart failure due to Tako-tsubo syndrome within 48 h of hospitalization. 相似文献
52.
This study is conducted on back skin of three female belong to Millivora capenesis wild animals. Histological preparations carried out to reveal the structural features of the stratum of epidermis. The skin ofMillivora capensis was covered with keratinized stratified squamous epithelium, the mean thickness is 427.85 ± 4.28 μm. The superficial layer is stratum corneum. The basic properties of this stratum consist of dead, flattened, polygonal cells which are free from nuclei and keratin accumulate in dead cells in order to give protective feature. The mean thickness of stratum corneum is 90.5 ± 2.44 μm. Beneath the stratum corneum, there is translucent layar composed of keratin fibrils and homogenous materials which is termed Eldin. The mean thickness of stratum lucidum is 18.14±0.52 μm. While the mean thickness of stratum granulosum intensive affinity to basophilic spinosum is formed from prickle cells with cytoplasmic processes like spines which represented the desmosomes. The mean thickness of both stratum basal is 55.63 ± 1.75 μm .Our histological findings revealed epidermal papillae extended to the papillary layer of dermis, and these papillae were bifurcates and some papillae fused with each other in order to give the rigidity and power to epidermis. 相似文献
53.
Drug-loaded temperature-sensitive liposomes (TSL) in combination with hyperthermia (HT) have attracted considerable attention for cancer treatment. Different TSL systems have been designed with wide variations in their temperature sensitivity and drug release profile. Low temperature-sensitive liposomes (LTSL) with the capacity for ultrafast drug release, traditional temperature-sensitive (TTSL) with intermediate drug release properties and non-temperature-sensitive liposomes (NTSL) (no drug release) were dual-labeled with (3)H-cholesteryl hexadecyl ether ((3)H-CHE) lipid and loaded with (14)C-doxorubicin ((14)C-Dox). Their blood profile, serum stability, tissue distribution and tumor localization (B16F10 melanoma) were studied after intravenous administration and mild HT treatment. LTSL showed higher affinity for the liver compared to TTSL and NTSL which were uptaken mainly by spleen. Under normal conditions (no HT) Dox leakage from liposomes was expected, higher for LTSL, less for TTSL and minimal for NTSL. Localized HT did not affect the overall blood circulation or organ accumulation for all TSL studied. Since LTSL showed ultrafast Dox release kinetics at 42 °C, the highest drug accumulation in tumors was observed using this system immediately after HT, however decreased significantly after 24 h. In contrast, TTSL and NTSL showed 2-3 fold increase in both liposome and Dox levels that indicated enhanced tumor extravasation of intact Dox-loaded liposomes during the 60 min HT applications. More interestingly, high levels of drug tumor accumulation were achieved 24 h post-HT. This study offers further understanding on how the mechanisms of drug release from temperature-sensitive liposomes affect their pharmacological profile under mild hyperthermia. 相似文献
54.
Ling?L.?Chuah Alexander?D.?Miras Laura?M.?Perry Andrew?H.?Frankel David?J.?Towey Zahraa?Al-MayahiEmail author William?Svensson Carel?W.?le Roux 《BMC nephrology》2018,19(1):383
Background
Most studies on obesity surgery have measured renal function using the estimated GFR. However, due to the reduction of muscle mass, and therefore creatinine that accompanies weight loss, such measures can falsely suggest an improvement in renal function. To balance the risks of surgery versus any potential benefits on renal function, we need to be able to determine renal function using valid and reliable methodologies. In this pilot study we aimed to measure renal function in patients with CKD undergoing obesity surgery using the gold standard 51Cr-EDTA GFR clearance methodology which is independent of measures of muscle mass.Methods
Nine consecutive obese patients with CKD underwent obesity surgery. Their renal function was assessed using 51Cr-EDTA GFR, cystatin C and serum creatinine as well as using eGFR equations including MDRD CKD Epi, Cockcroft Gault and CKD Epi cystatin before and 12?months after surgery.Results
Renal function using the 51Cr-EDTA measured GFR did not change significantly after surgery. Similar results were obtained when Cystatin C, CKD Epi cystatin, CKD Epi cystatin creatinine and adjusted Cockcroft Gault Creatinine clearance methods were used. In contrast there were either trends or significant improvements in renal function measured using the MDRD and CKD Epi equations.Conclusions
In this pilot study using the gold standard 51Cr-EDTA method we found stabilisation in renal function after obesity surgery. Until further definitive data emerge it is critical to balance the risk and benefits of surgery, especially if renal function may not improve as often as previously suggested.Trial registration
ClinicalTrials.gov NCT01507350. Registered June 2011.55.
56.
57.
Mustapha El Lakis Andreas Giannakou Pavel J. Nockel Douglas Wiseman Sudheer Kumar Gara Dhaval Patel Zahraa Abdul Sater Yevgeniya Y. Kushchayeva Joanna Klubo-Gwiezdzinska Naris Nilubol Maria J. Merino Electron Kebebew 《Surgery》2019,165(1):50-57
Background
There are conflicting reports on whether familial nonmedullary thyroid cancer is more aggressive than sporadic nonmedullary thyroid cancer. Our aim was to determine if the clinical and pathologic characteristics of familial nonmedullary thyroid cancer are different than nonmedullary thyroid cancer.Methods
We compared patients with familial nonmedullary thyroid cancer to a cohort of 53,571 nonmedullary thyroid cancer patients from the Surveillance, Epidemiology, and End Results database.Results
A total of 78 patients with familial nonmedullary thyroid cancer from 31 kindreds presented at a younger age (P?=?.04) and had a greater rate of T1 disease (P?=?.019), lymph node metastasis (P?=?.002), and the classic variant of papillary thyroid cancer on histology (P < .001) compared with the Surveillance, Epidemiology, and End Results cohort. Patients with ≥3 affected family members presented at a younger age (P?=?.04), had a lesser female-to-male ratio (P?=?.04), and had a greater rate of lymph node metastasis (P?=?.009). Compared with the Surveillance, Epidemiology, and End Results cohort, we found a higher prevalence of lymph node metastasis in familial nonmedullary thyroid cancer index cases (P?=?.003) but not in those diagnosed by screening ultrasonography (P?=?.58).Conclusion
Patients with familial nonmedullary thyroid cancer present at a younger age and have a greater rate of lymph node metastasis. The treatment for familial nonmedullary thyroid cancer should be more aggressive in patients who present clinically and in those who have ≥3 first-degree relatives affected. 相似文献58.
Naykky Singh Ospina Diane Donegan Rene Rodriguez-Gutierrez Zahraa Al-Hilli William F. Young 《The American journal of medicine》2017,130(5):603-605
Background
Zollinger-Ellison syndrome is a rare cause of tumoral hypergastrinemia; 1 of 5 patients with this syndrome also has multiple endocrine neoplasia type 1. The diagnosis of this disease is complicated by the widespread use of proton pump inhibitors that can elevate serum gastrin levels, the cornerstone for biochemical diagnosis. Abrupt discontinuation of proton pump inhibitors could lead to adverse outcomes. Clinician awareness of the relationship between Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1 could lead to a safer diagnostic pathway.Methods
We conducted a retrospective review of a cohort of patients with multiple endocrine neoplasia type 1.Results
There were 287 patients with multiple endocrine neoplasia type 1 (73 with gastrinoma) evaluated between 1997 and 2014. Two patients experienced adverse events after proton pump inhibitor therapy was discontinued to re-measure serum gastrin level during the evaluation of severe peptic ulcer disease. In both cases, the diagnosis of multiple endocrine neoplasia type 1 was made after proton pump therapy was discontinued.Conclusion
Abrupt discontinuation of proton pump therapy can lead to adverse outcomes in patients with Zollinger-Ellison syndrome. Clinical assessment for features of multiple endocrine neoplasia type 1 (eg, serum calcium levels, personal and family history of hypercalcemia, pituitary or pancreatic tumors) could identify patients with higher risk for a tumoral source of hypergastrinemia where imaging studies can help support the diagnosis without the potential side effects of abrupt discontinuation of proton pump inhibitor therapy. 相似文献59.
Fan Betty Valente Stephanie A. Shilad Sabrina Al-Hilli Zahraa Radford Diane M. Tu Chao Grobmyer Stephen R. 《Annals of surgical oncology》2019,26(10):3109-3114
Annals of Surgical Oncology - No clear standards regarding number or type of narcotics for adequate postoperative pain control have been established in breast surgery. The authors of this study... 相似文献
60.
Ila Gautham Diane M. Radford Christopher S. Kovacs Benjamin C. Calhoun Gary W. Procop Laura B. Shepardson Andrea E. Dawson Erinn P. Downs‐Kelly Gloria X. Zhang Zahraa Al‐Hilli Alicia A. Fanning Deborah A. Wilson Charles D. Sturgis 《The breast journal》2019,25(1):80-85
Granulomatous mastitis is an uncommon inflammatory disease that typically presents with painful breast lesions. Recent publications have brought to light a specific subset of granulomatous mastitis patients with a distinct histological pattern of disease termed, “cystic neutrophilic granulomatous mastitis” (CNGM). Although many cases of granulomatous lobular mastitis have been thought to be idiopathic, this rare subset of an uncommon disease has been linked to infections with Corynebacterium species. Herein, a cohort of CNGM patients from a large, tertiary care, North‐American, academic medical center is presented. Correlative demographic, clinical, radiographic, pathologic, microbiologic, management, and outcomes data are provided. Collaborative communication between specialists to accurately diagnose and manage these patients is essential to decreasing potential morbidity. 相似文献