全文获取类型
收费全文 | 349246篇 |
免费 | 13199篇 |
国内免费 | 5687篇 |
专业分类
耳鼻咽喉 | 3328篇 |
儿科学 | 10140篇 |
妇产科学 | 7635篇 |
基础医学 | 40307篇 |
口腔科学 | 5986篇 |
临床医学 | 28803篇 |
内科学 | 59691篇 |
皮肤病学 | 3628篇 |
神经病学 | 26940篇 |
特种医学 | 15114篇 |
外国民族医学 | 39篇 |
外科学 | 51463篇 |
综合类 | 18115篇 |
现状与发展 | 13篇 |
一般理论 | 37篇 |
预防医学 | 30661篇 |
眼科学 | 7118篇 |
药学 | 25727篇 |
53篇 | |
中国医学 | 5534篇 |
肿瘤学 | 27800篇 |
出版年
2023年 | 1150篇 |
2022年 | 2798篇 |
2021年 | 3906篇 |
2020年 | 2960篇 |
2019年 | 2903篇 |
2018年 | 25249篇 |
2017年 | 20293篇 |
2016年 | 22273篇 |
2015年 | 5171篇 |
2014年 | 6226篇 |
2013年 | 6449篇 |
2012年 | 15146篇 |
2011年 | 29653篇 |
2010年 | 24470篇 |
2009年 | 16302篇 |
2008年 | 25973篇 |
2007年 | 28152篇 |
2006年 | 7060篇 |
2005年 | 8020篇 |
2004年 | 8068篇 |
2003年 | 8730篇 |
2002年 | 6466篇 |
2001年 | 8136篇 |
2000年 | 8369篇 |
1999年 | 6869篇 |
1998年 | 2650篇 |
1997年 | 2145篇 |
1996年 | 1497篇 |
1995年 | 1405篇 |
1994年 | 1224篇 |
1993年 | 1085篇 |
1992年 | 4055篇 |
1991年 | 4168篇 |
1990年 | 3865篇 |
1989年 | 3769篇 |
1988年 | 3630篇 |
1987年 | 3449篇 |
1986年 | 3195篇 |
1985年 | 3063篇 |
1984年 | 2114篇 |
1983年 | 1841篇 |
1979年 | 1944篇 |
1978年 | 1205篇 |
1975年 | 1207篇 |
1974年 | 1381篇 |
1973年 | 1426篇 |
1972年 | 1366篇 |
1971年 | 1250篇 |
1970年 | 1160篇 |
1969年 | 1142篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Statutory reimbursement agencies as well as private insurers throughout member states of the Organization for Economic Cooperation and Development (OECD) reimburse the cost of medicines on the basis of criteria that include robust clinical evidence, budget impact analysis, and incremental cost effectiveness. The Centers for Medicare and Medicaid Services (CMS) in the US are no exception to this rule and are, in principle, seeking to maximize benefit for their Medicare enrollees, whilst ensuring reasonable drug outlays for the small number of drugs that they reimburse. This paper provides a retrospective analysis of the way two functionally equivalent drugs are treated for reimbursement purposes by the CMS; the period under consideration was 2001–3. The two drugs, epoetin-α and darbepoetin-α, are used for the treatment of anemia in renal failure and in patients receiving chemotherapy. By reviewing the publicly available pharmacological and clinical data of epoetin-α and darbepoetin-α, the paper confirms the two drugs’ functional equivalence, despite their structural differences. The implications of dose conversion ratios and costs to Medicare are subsequently explored. It is argued that the issue of dose equivalence between epoetin-α and darbepoetin-α has significant implications for patients, practitioners, and payors. A payor’s perspective is adopted in this respect, whereby clinical evidence and pricing data are used simultaneously. Based on the clinical evidence, a dose conversion ratio for epoetin-α:darbepoetin-α is established, which achieves a comparable clinical effect for the two drugs and this is set to be <254IU:1μg. The incremental costs to Medicare are calculated subsequently. The Average Wholesale Price and the Outpatient Prospective Payment System rule that Medicare uses to reimburse providers are used and suggest that treatment of cancer patients with chemotherapy-related anemia with epoetin-α would save Medicare an estimated $US600 million each year. Patients would also benefit significantly in terms of lower co-payments for epoetin-α. The evidence is supportive of the decision made by the CMS to reimburse the two drugs at the rate reflecting the achievement of comparable clinical effects and therefore reducing the pass-through payments for darbepoetin-α to zero for the 2002–3 fiscal year. 相似文献
92.
93.
94.
95.
96.
Z. Malazgirt K. Topgul S. Sokmen S. Ersin A. G. Turkcapar H. Gok N. Gonullu M. Paksoy M. Ertem 《Hernia》2006,10(4):326-330
Most of the papers published on spigelian hernia are either case reports or small retrospective series. In this prospective
multicenter study, we aimed to outline the specific features of spigelian hernias and patients’ characteristics more clearly.
Surgeons enrolled patients to be entered into the database as they diagnosed and treated the hernias at will. The baseline
and surgical outcome parameters were noted in each patient. A painful mass was the main presenting complaint in half of 34
patients. Accurate preoperative diagnosis was possible in 31 patients. Open intraperitoneal mesh repair was the preferred
technique. The mean hospital stay and time until return to normal daily activities were 4.1 and 15.6 days. Although a rare
condition, diagnosis of a spigelian hernia is not difficult once remembered. Its surgical repair seems to cause few complications
and is very well tolerated by the patient. 相似文献
97.
98.
Single or combined monoclonal antibodies (McAbs) Zh53, Zh820, and Zh2-1 have been used to eliminate malignant clonogenic cells from human bone marrow. The test of cytotoxicity showed that all of these McAbs could express high specific cytotoxic action against HL-60 cells and were selectively complement-dependent cytotoxic to various types of fresh leukemic cells. Clonogenic assay detected that single treatment with antibody and rabbit complement (RC) could reduce clonogenic units of HL-60 cells by more than 2 logs and two treatments reduced clonogenic units by more than 4 logs. However, combination of 2 McAbs could reduce clonogenic units by 4-5 logs. The data suggest that multiple treatments with McAbs and RC or a combination of 2 McAbs are more effective than a single treatment in eliminating clonogenic tumor cells. Treatment of normal human bone marrow with Zh53, Zh2-1 and RC did not produce a loss of normal CFU-GM, but treatment with Zh820 reduced the clonic units of normal CFU-GM by 24%.
相似文献
99.
This paper reports on 1330 infants, from birth to 24 months old, suffering from diarrhoea and moderate to severe dehydration who were hospitalized in Tehran University Hospital over a period of 11 months. Fifteen per cent of them had signs of shock and 36% had marasmus. All patients were treated orally in two phases: rehydration therapy and maintenance therapy. For rehydration, an isotonic fluid (sodium 80 mmol l-1, potassium 20 mmol l-1) was administered at a rate of 40 ml kg-1 h-1 until all signs of dehydration disappeared. Following complete hydration, the patients were discharged and maintenance therapy was performed at home, by mothers, administering Maintenance Solution (sodium 40 mmol l-1, potassium 30 mmol l-1) ad libitum. Intravenous fluids were not used, even in severe dehydration. The efficacy and safety of this regimen were confirmed by rapid and successful rehydration in 99.7% of the patients and correction of a wide variety of electrolyte abnormalities present on admission, though some relapsed. The study suggests that this protocol could be employed in varied types and severities of dehydration and electrolyte abnormalities, and could also be used in both well nourished infants and in those with severe marasmus. It also demonstrates that mothers can serve as effective health workers and can perform successful maintenance therapy. Nine per cent of treated children required readmission to hospital within 24 h of discharge and a further 8% were hospitalized elsewhere with recurrent symptoms. 相似文献
100.