全文获取类型
收费全文 | 5078篇 |
免费 | 253篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 120篇 |
妇产科学 | 84篇 |
基础医学 | 599篇 |
口腔科学 | 160篇 |
临床医学 | 356篇 |
内科学 | 1215篇 |
皮肤病学 | 157篇 |
神经病学 | 420篇 |
特种医学 | 311篇 |
外科学 | 539篇 |
综合类 | 16篇 |
预防医学 | 215篇 |
眼科学 | 156篇 |
药学 | 423篇 |
中国医学 | 36篇 |
肿瘤学 | 511篇 |
出版年
2023年 | 33篇 |
2022年 | 62篇 |
2021年 | 107篇 |
2020年 | 81篇 |
2019年 | 89篇 |
2018年 | 118篇 |
2017年 | 94篇 |
2016年 | 108篇 |
2015年 | 101篇 |
2014年 | 151篇 |
2013年 | 167篇 |
2012年 | 288篇 |
2011年 | 337篇 |
2010年 | 183篇 |
2009年 | 149篇 |
2008年 | 275篇 |
2007年 | 315篇 |
2006年 | 280篇 |
2005年 | 271篇 |
2004年 | 268篇 |
2003年 | 255篇 |
2002年 | 236篇 |
2001年 | 116篇 |
2000年 | 94篇 |
1999年 | 104篇 |
1998年 | 67篇 |
1997年 | 52篇 |
1996年 | 43篇 |
1995年 | 31篇 |
1994年 | 25篇 |
1993年 | 37篇 |
1992年 | 70篇 |
1991年 | 99篇 |
1990年 | 82篇 |
1989年 | 67篇 |
1988年 | 64篇 |
1987年 | 63篇 |
1986年 | 56篇 |
1985年 | 60篇 |
1984年 | 43篇 |
1983年 | 26篇 |
1982年 | 11篇 |
1981年 | 17篇 |
1979年 | 21篇 |
1978年 | 22篇 |
1977年 | 11篇 |
1974年 | 9篇 |
1973年 | 14篇 |
1972年 | 11篇 |
1969年 | 8篇 |
排序方式: 共有5355条查询结果,搜索用时 15 毫秒
61.
Yuko Isoyama-Shirakawa Katsumasa Nakamura Madoka Abe Naonobu Kunitake Keiji Matsumoto Saiji Ohga Tomonari Sasaki Satoru Uehara Kazuhiro Okushima Yoshiyuki Shioyama Hiroshi Honda 《Journal of radiation research》2015,56(3):583-587
It has been suggested that pain control during intracavitary brachytherapy for cervical cancer is insufficient in most hospitals in Japan. Our hospital began using caudal epidural anesthesia during high-dose-rate (HDR) intracavitary brachytherapy in 2011. The purpose of the present study was to retrospectively investigate the effects of caudal epidural anesthesia during HDR intracavitary brachytherapy for cervical cancer patients. Caudal epidural anesthesia for 34 cervical cancer patients was performed during HDR intracavitary brachytherapy between October 2011 and August 2013. We used the patients'' self-reported Numeric Rating Scale (NRS) score at the first session of HDR intracavitary brachytherapy as a subjective evaluation of pain. We compared NRS scores of the patients with anesthesia with those of 30 patients who underwent HDR intracavitary brachytherapy without sacral epidural anesthesia at our hospital between May 2010 and August 2011. Caudal epidural anesthesia succeeded in 33 patients (97%), and the NRS score was recorded in 30 patients. The mean NRS score of the anesthesia group was 5.17 ± 2.97, significantly lower than that of the control group''s 6.80 ± 2.59 (P = 0.035). The caudal epidural block resulted in no side-effects. Caudal epidural anesthesia is an effective and safe anesthesia option during HDR intracavitary brachytherapy for cervical cancer. 相似文献
62.
Naohiro Tsuyama Hajime Mizuno Atsushi Katafuchi Yu Abe Yumiko Kurosu Mitsuaki Yoshida Kenji Kamiya Akira Sakai 《Journal of radiation research》2015,56(1):46-58
Ionizing radiation (IR) induces cellular stress responses, such as signal transduction, gene expression, protein modification, and metabolite change that affect cellular behavior. We analyzed X-irradiated human Epstein-Barr virus-transformed B lymphoblastoid cells and normal fibroblasts to search for metabolites that would be suitable IR-responsive markers by Liquid Chromotography–Mass spectrometry (LC–MS). Mass spectra, as analyzed with principal component analysis, showed that the proportion of peaks with IR-induced change was relatively small compared with the influence of culture time. Dozens of peaks that had either been upregulated or downregulated by IR were extracted as candidate IR markers. The IR-changed peaks were identified by comparing mock-treated groups to 100 mGy-irradiated groups that had recovered after 10 h, and the results indicated that the metabolites involved in nucleoside synthesis increased and that some acylcarnitine levels decreased in B lymphoblastoids. Some peaks changed by as much as 20 mGy, indicating the presence of an IR-sensitive signal transduction/metabolism control mechanism in these cells. On the other hand, we could not find common IR-changed peaks in fibroblasts of different origin. These data suggest that cell phenotype-specific pathways exist, even in low-dose responses, and could determine cell behavior. 相似文献
63.
64.
65.
Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug‐induced liver injury in rats 下载免费PDF全文
Yutaka Tonomura Yuki Kato Hiroyuki Hanafusa Yuji Morikawa Keigo Matsuyama Takeki Uehara Motonobu Ueno Mikinori Torii 《Journal of applied toxicology : JAT》2015,35(2):165-172
Traditional biomarkers such as alanine and aspartate aminotransferase (ALT, AST) and total bilirubin (TBIL) have been widely used for detecting drug‐induced liver injury (DILI). Although the Food and Drug Administration (FDA) proposed standardized thresholds for human as Hy's law, those for animals have not been determined, and predictability of these biomarkers for future onset of hepatic lesions remains unclear. In this study, we investigated these diagnostic and predictive performance of 10 traditional biomarkers for liver injury by receiver‐operating characteristic (ROC) curve, using a free‐access database where 142 hepatotoxic or non‐hepatotoxic compounds were administrated to male rats (n = 5253). Standardization of each biomarker value was achieved by calculating the ratio to control mean value, and the thresholds were determined under the condition of permitting 5% false positive. Of these 10 biomarkers, AST showed the best diagnostic performance. Furthermore, ALT and TBIL also showed high performance under the situation of hepatocellular necrosis and bile duct injury, respectively. Additionally, the availability of the diagnostic thresholds in difference testing facility was confirmed by the application of these thresholds to in‐house prepared dataset. Meanwhile, incorrect diagnosis by the thresholds was also observed. Regarding prediction, all 10 biomarkers showed insufficient performance for future onset of hepatic lesions. In conclusion, the standardized diagnostic thresholds enable consistent evaluation of traditional biomarkers among different facilities, whereas it was suggested that novel biomarker is required for more accurate diagnosis and prediction of DILI. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
66.
Shingo Nasu Kunimitsu Kawahara Yuki Han Norio Okamoto Yoshitaka Tamura Hidekazu Suzuki Takayuki Shiroyama Yumiko Samejima Tomohiro Kanai Yoshimi Noda Ayako Tanaka Naoko Morishita Kayo Ueda Shoji Hashimoto Tomonori Hirashima Takayuki Nagai 《Internal medicine (Tokyo, Japan)》2021,60(3):445
Miliary tuberculosis is a potentially lethal type of tuberculosis that results from the hematogenous dissemination of Mycobacterium tuberculosis bacilli. We herein describe the case of a 34-year-old man that presented with a one-month history of cough and fever, while his sputum smear results were negative. Chest computed tomography revealed bilateral centrilobular ground-glass opacification (GGO), suggestive of hypersensitivity pneumonitis; thus, bronchoscopy was performed. Cryobiopsy specimens revealed necrotic granulomas. A re-examination of sputum after bronchoscopy identified Mycobacterium tuberculosis, and miliary tuberculosis was diagnosed. A cryobiopsy might be useful for diagnosing miliary tuberculosis pathologically, particularly when miliary nodules may be masked by GGO. 相似文献
67.
Miwa Kawanaka Ken Nishino Yumiko Morimoto Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Mitsuhiko Suehiro Takako Sasai Ken Haruma Hirofumi Kawamoto 《Internal medicine (Tokyo, Japan)》2021,60(9):1397
A 44-year-old patient progressed from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) cirrhosis. She was diagnosed with NAFL via a liver biopsy. At 56 years old, she was diagnosed with NASH stage 3 via a second liver biopsy. One year later, she was diagnosed with NASH cirrhosis via a third liver biopsy. This is the first study to report the gradual deterioration of liver histology shown via three liver biopsies and fibrosis markers in a patient who progressed from NAFL to NASH cirrhosis. Following menopause, it is necessary to be aware of the rapid development of liver fibrosis. 相似文献
68.
Shinichi Wada Mayu Kamei Naoko Uehara Koji Tsuzaki Toshiaki Hamano 《Internal medicine (Tokyo, Japan)》2021,60(10):1607
A 69-year-old man was admitted to our hospital for progressive muscle weakness in both lower limbs and limb ataxia (day 0). Nerve conduction studies showed low compound muscle action potential amplitudes at rest and increased amplitudes after maximum voluntary contraction. Blood testing revealed SOX-1 antibodies. He was diagnosed with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS). He died from aspiration pneumonia on day 9. Small-cell lung carcinoma (SCLC), which had not been obvious on computed tomography, was found during the autopsy. Patients with PCD-LEMS who test positive for SOX-1 antibodies should be carefully evaluated for SCLC. 相似文献
69.
70.
Matsuda Hiroshi Okita Kyoji Motoi Yumiko Mizuno Toshiki Ikeda Manabu Sanjo Nobuo Murakami Koji Kambe Taiki Takayama Toshiki Yamada Kei Suehiro Takashi Matsunaga Keiko Yokota Takanori Tateishi Ukihide Shigemoto Yoko Kimura Yukio Chiba Emiko Kawashima Takahiro Tomo Yui Tachimori Hisateru Kimura Yuichi Sato Noriko 《Annals of nuclear medicine》2022,36(12):1039-1049
Annals of Nuclear Medicine - Amyloid positron emission tomography (PET) can reliably detect senile plaques and fluorinated ligands are approved for clinical use. However, the clinical impact of... 相似文献