全文获取类型
收费全文 | 371篇 |
免费 | 26篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 5篇 |
妇产科学 | 4篇 |
基础医学 | 54篇 |
口腔科学 | 2篇 |
临床医学 | 31篇 |
内科学 | 142篇 |
皮肤病学 | 6篇 |
神经病学 | 17篇 |
特种医学 | 11篇 |
外科学 | 58篇 |
综合类 | 1篇 |
预防医学 | 6篇 |
眼科学 | 2篇 |
药学 | 22篇 |
肿瘤学 | 35篇 |
出版年
2024年 | 6篇 |
2023年 | 11篇 |
2022年 | 26篇 |
2021年 | 31篇 |
2020年 | 17篇 |
2019年 | 22篇 |
2018年 | 18篇 |
2017年 | 17篇 |
2016年 | 14篇 |
2015年 | 9篇 |
2014年 | 15篇 |
2013年 | 24篇 |
2012年 | 30篇 |
2011年 | 24篇 |
2010年 | 12篇 |
2009年 | 9篇 |
2008年 | 25篇 |
2007年 | 24篇 |
2006年 | 17篇 |
2005年 | 12篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 2篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1993年 | 1篇 |
1989年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1965年 | 1篇 |
1926年 | 1篇 |
排序方式: 共有399条查询结果,搜索用时 15 毫秒
41.
Kunihiko TERADA Shigeo MURO Tadashi OHARA Akane HARUNA Satoshi MARUMO Megumi KUDO Emiko OGAWA Yuma HOSHINO Toyohiro HIRAI Akio NIIMI Michiaki MISHIMA 《Respirology (Carlton, Vic.)》2009,14(8):1151-1155
Background and objective: The causes of exacerbations in COPD patients are poorly understood. This study examined the association between cough-reflex sensitivity in patients with stable COPD and the frequency of subsequent exacerbations.
Methods: The sampling frame for cases and controls for this study was patients attending a hospital outpatient clinic. cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C5 ). Subsequent COPD exacerbations were identified prospectively via symptom-based diaries over a 12-month period.
Results: The study group comprised 45 COPD subjects and 10 controls. Mean log C5 was lower in the COPD group than in the control group (0.97 (95% confidence interval (CI): 0.76–1.18) versus 1.26 (95% CI: 0.81–1.71), P = 0.095). In the COPD group, log C5 was negatively correlated with serum CRP level ( r = −0.36, P = 0.02) and significantly associated with the exacerbation frequency ( r = −0.38, P = 0.01). Stepwise multiple regression analysis showed that cough-reflex sensitivity was significantly associated with exacerbation frequency ( r 2 = 0.15, P = 0.01).
Conclusions: Hypersensitivity of the cough reflex to inhaled capsaicin might reflect airway inflammation in stable COPD patients, which predisposes to frequent exacerbations. 相似文献
Methods: The sampling frame for cases and controls for this study was patients attending a hospital outpatient clinic. cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C
Results: The study group comprised 45 COPD subjects and 10 controls. Mean log C
Conclusions: Hypersensitivity of the cough reflex to inhaled capsaicin might reflect airway inflammation in stable COPD patients, which predisposes to frequent exacerbations. 相似文献
42.
Toshiyuki Kita Masaki Fujimura Shigeharu Myou Kazuyoshi Watanabe Yuko Waseda Shinji Nakao 《Allergology international》2009,58(2):267-275
BackgroundPhosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling.ObjectiveThe aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 and 1 dual inhibitor, on chronic airway inflammation and remodeling following chronic exposure to aerosolized antigen in mice.MethodsOvalbumin (OVA) was administered intraperitoneally to BALB/c mice on days 0 and 14, and the mice were then exposed to aerosolized OVA daily for 4 weeks. Twenty-four hours following the final inhalation, bronchial responsiveness to acetylcholine was measured, and histologic examination and hydroxyproline content of the lung were evaluated.ResultsBronchial responsiveness to acetylcholine, number of inflammatory cells and eosinophils in the lamina propria, thickness of epithelial and subepithelial collagen layers, and hydroxyproline content of the lung increased following chronic exposure to OVA for 7 weeks. KF19514 significantly prevented all of these changes.ConclusionsPhosphodiesterase 4 and 1 inhibitors such as KF19514 may help prevent bronchial hyperresponsiveness and chronic asthma-induced airway remodeling. 相似文献
43.
44.
Sato A Hara T Nakamura H Kato N Hoshino Y Kondo N Mishima M Yodoi J 《Antioxidants & redox signaling》2006,8(9-10):1891-1896
Thioredoxin-1 (TRX) is a small redox-active protein with antioxidative effects and redox-regulating functions. Cigarette smoking is a major etiological factor in the pathogenesis of a variety of diseases and recruits systemic immune and inflammatory responses. This report demonstrates that TRX attenuates the systemic inflammatory responses induced by cigarette smoking. The mRNA expressions of tumor necrosis factor alpha (TNF-alpha) and macrophage migration inhibitory factor (MIF) were suppressed in the spleen of TRX overexpressing transgenic mice (TRX-tg) exposed to cigarette smoking, compared with control C57BL/6 mice. In addition, protein carbonylation, a marker of cellular protein oxidation, was enhanced by cigarette smoking in the tissues of heart and liver in control mice more than in TRX-tg mice. These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking. 相似文献
45.
Yuma Yamada Kohei Nakamura Ryo Furukawa Eriko Kawamura Takuya Moriwaki Kenji Matsumoto Katsuhiro Okuda Mitsuru Shindo Hideyoshi Harashima 《Journal of pharmaceutical sciences》2013,102(3):1008-1015
The fact that mitochondrial dysfunction has been implicated in a variety of human diseases suggests that they would be expected as a target organelle for these diseases. Bongkrekic acid (BKA) is a chemical that functions as a ligand of the adenine nucleotide translocator and is known to potently inhibit the mitochondrial permeability transition that is associated with apoptosis. Thus, delivering it to mitochondria would be an innovative therapy for the treatment of mitochondrial diseases that are largely associated with apoptosis. Here, we report on the use of a MITO-Porter, an innovative nanocarrier for mitochondrial delivery via mitochondrial membrane fusion, for delivering BKA to mitochondria. We first constructed a BKA-MITO-Porter, in which BKA is contained in lipid envelopes of a MITO-Porter. We then confirmed that the BKA–MITO-Porter was efficiently internalized into cells and is delivered to mitochondria, similar to a conventional MITO-Porter. Moreover, we evaluated the antiapoptosis effect of the BKA–MITO-Porter in HeLa cells by measuring caspase 3/7 activity. The findings confirmed that the BKA–MITO-Porter showed a strong antiapoptosis effect compared with naked BKA. The results reported here demonstrate its potential for the use in therapies aimed at mitochondrial diseases, as a mitochondrial medicine candidate. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:1008–1015, 2013 相似文献
46.
47.
Takafumi Minami Yuma Fukutomi Reiko Inada Manabu Tsuda Kiyoshi Sekiya Masaki Miyazaki Fumio Tsuji Masami Taniguchi 《Allergology international》2019,68(4):440-449
BackgroundIdentification of sensitized allergens for patients with respiratory allergy is an important step in disease care and environmental allergen control. The Japanese archipelago belongs to various climate categories due to its length from north to south which transverse the subarctic in the north to the subtropical in the south, suggesting substantial regional differences in dominant environmental allergens. However, few studies have assessed the regional differences in the prevalence of sensitization to environmental allergens.MethodsWe requested three major clinical testing laboratories to provide us with summarized results of antigen-specific IgE-antibody (Ab) measurements. These measurements were collected for clinical purposes throughout Japan from 2002 through 2011. The prevalence of positivity for IgE-Ab against 19 environmental allergens was calculated for each prefecture in order to evaluate regional differences.ResultsTest data on specific IgE-Ab of 19,969,753 orders were analyzed. The prevalence of positivity for house dust mites was high and the regional difference was low, whereas apparent regional differences were found for pollen, insects, and fungi. The prevalence of positivity for Japanese cedar was low in Hokkaido and Okinawa, while those to alder was highest in Hokkaido. Higher prevalence for insects was observed in southern areas (Okinawa and prefectures in Kyusyu).ConclusionsFindings of this study clearly demonstrated regional differences in the prevalence of sensitization to environmental allergens in Japan and the study also provides useful information for the clinician when deciding which allergens should preferentially be measured for IgE-Ab after considering regional difference. 相似文献
48.
Masui K Yoshimura K Sakura Y Ito H Yoshida T Mishina M Okuno H 《Hinyokika kiyo. Acta urologica Japonica》2011,57(8):417-423
We investigated potential risk factors, including factors related to lower urinary tract symptoms (LUTS), for falls and fractures at night among outpatients and inpatients in a general hospital, via a questionnaire. The questionnaire included items to record the age, sex, number of consulting doctors, history of 11 particular medical diseases, LUTS, sleep, and falls and fractures at night. We distributed the questionnaire to 1,334 patients 51 years old or older in our hospital. Of the questionnaires completed, 96.9% were valid for analysis. Multivariate analyses revealed that "drinking water before bedtime or while in bed" was the strongest risk factor (odds ratio=7.499) for bone fractures while "postural syncope" was the strongest risk factor (odds ratio=5.041, except past medical history) for falls. In terms of LUTS, urge incontinence was a significant risk factor for falls. 相似文献
49.
Satoshi Yamaguchi Mariko Ishida Kanako Hidaka Shinya Gomi Sachiyo Takayama Kazuki Sato Yuma Yoshioka Nozomu Wakayama Kuwon Sekine Shoji Matsune Toshiaki Otsuka Kimihiro Okubo 《Auris, nasus, larynx》2018,45(3):533-539
Objective
Clarification of the association between the swallowing function and respiratory and phonatory functions.Methods
The subjects were 30 patients with a chief complaint of swallowing disorder with clear consciousness capable of retaining a sitting position. Patients with organic and functional diseases of the larynx were excluded. Twenty-two and eight patients were male and female, respectively, and the mean age was 77.0 ± 14.6 years old. The chest expansion score was measured as an index of the respiratory function, and the maximum phonation time (MPT) was measured as an index of the phonatory function. The presence or absence of aspiration was judged using videoendoscopic swallowing study (VESS) and videofluoroscopic swallow studies (VFSS). The patients were divided into those with and without aspiration, and the chest expansion score and MPT were compared. In addition, the distance of laryngeal elevation was measured in the lateral view of VFSS, and its correlations with the chest expansion score and MPT were closely analyzed. To evaluate reliability of the test, the distance of laryngeal elevation and videoendoscopic score were compared between the presence and absence of aspiration.Results
The distance of laryngeal elevation was significantly shortened and the videoendoscopic score was significantly higher in the group with aspiration, as previously reported. On comparison of the chest expansion score between the groups with and without aspiration, no significant difference was noted at the axillary or xiphoid process level, and shortening was significant only at the 10th rib level in the group with aspiration. On comparison of MPT, it was significantly shortened in the group with aspiration. In addition, a significant positive correlation with the distance of laryngeal elevation was noted in both chest expansion score and MPT.Conclusion
It was suggested that declines of the respiratory and phonatory functions are risk factors of aspiration through limiting laryngeal elevation, and the chest expansion score at the 10th rib level and MPT are useful for screening of aspiration. 相似文献50.
Tatsuya Konishi Hiroaki Ogawa Yuho Najima Shinpei Hashimoto Atsushi Wada Hiroto Adachi Ryosuke Konuma Yuya Kishida Akihito Nagata Yuta Yamada Satoshi Kaito Junichi Mukae Atsushi Marumo Yuma Noguchi Takashi Toya Aiko Igarashi Takeshi Kobayashi Kazuteru Ohashi Noriko Doki Katsuyuki Karasawa 《Journal of radiation research》2020,61(6):969