全文获取类型
收费全文 | 619篇 |
免费 | 14篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 7篇 |
妇产科学 | 26篇 |
基础医学 | 41篇 |
口腔科学 | 1篇 |
临床医学 | 25篇 |
内科学 | 159篇 |
皮肤病学 | 26篇 |
神经病学 | 10篇 |
特种医学 | 13篇 |
外科学 | 287篇 |
综合类 | 5篇 |
预防医学 | 6篇 |
眼科学 | 2篇 |
药学 | 5篇 |
中国医学 | 1篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 7篇 |
2022年 | 13篇 |
2021年 | 26篇 |
2020年 | 19篇 |
2019年 | 15篇 |
2018年 | 19篇 |
2017年 | 11篇 |
2016年 | 9篇 |
2015年 | 15篇 |
2014年 | 22篇 |
2013年 | 25篇 |
2012年 | 32篇 |
2011年 | 53篇 |
2010年 | 22篇 |
2009年 | 17篇 |
2008年 | 26篇 |
2007年 | 28篇 |
2006年 | 32篇 |
2005年 | 45篇 |
2004年 | 19篇 |
2003年 | 23篇 |
2002年 | 26篇 |
2001年 | 6篇 |
2000年 | 22篇 |
1999年 | 14篇 |
1998年 | 12篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1991年 | 9篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1979年 | 5篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1965年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有642条查询结果,搜索用时 10 毫秒
11.
Tomoko Shimoike Masayoshi Goto Itsuro Nakano Takeaki Sato Yoshikatsu Migita Tetsuhide Ito Toshihiko Yanase Shu-Ichi Sezai Tsunemichi Suzuki Hajime Nawata 《Journal of gastroenterology》1997,32(6):830-835
A case of acinar-islet cell carcinoma presenting as insulinoma is reported. The patient was a 28-year-old man who presented with two convulsive episodes. Fajans' index [immunoreactive insulin (IRI; μU/ml/ glucose mg/dl)] and Turner's [IRI (μU/ml) × 100/glucose (mg/dl)—30] index were high (2.8 and 308, respectively), as were serum proinsulin levels (550pg/ml). Abdominal computed tomography and angiography revealed a highly vascular tumor in the pancreatic tail and several similar tumors in the liver. Histologic features of a biopsy specimen from a hepatic tumor were those of a malignant pancreatic endocrine tumor. Insulin secretion by the liver metastases was confirmed by venous sampling after arterial stimulation with calcium. These findings led us to diagnose malignant insulinoma with liver metastases. Serum levels of α-fetoprotein and trypsin were markedly elevated, to 2234ng/ml (normal <10) and 22000ng/ml (normal<460) respectively, and these levels continued to rise with further growth of the liver metastases. Immunohistochemically, the metastatic liver tumor specimen was positive for α-fetoprotein, α1-antichymotrypsin, chromogranin A, and neuron-specific enolase. These findings of amphicrine features in the tumor were indicative of acinar-islet cell carcinoma that produced α-fetoprotein and trypsin in addition to insulin. 相似文献
12.
Akira Sezai Shunji Osaka Hiroko Yaoita Yusuke Ishii Munehito Arimoto Hiroaki Hata Motomi Shiono 《Annals of thoracic and cardiovascular surgery》2015,21(3):247-253
In this study, we investigated the early and long-term results of conventional aortic valve replacement (AVR) in very old patients.Methods: Seventy-five patients with aortic stenosis underwent conventional AVR for patients aged 80 years.We examined early death and major adverse cardiovascular and cerebrovascular event (MACCE).Results: The operative mortality was 0% for isolated AVR and 19.2% for concomitant surgery. The postoperative survival rate and MACCE free-rate were no significant differences between the isolated AVR and the concomitant surgery. Univariate analysis confirmed that cardiac dysfunction, severe chronic kidney disease (CKD), hemodialysis, + coronary artery bypass grafting, and norepinephrine use were risk factor of early death. Univariate analysis confirmed that severe CKD, BNP >1000 pg/ml, aortic cross clamping time (ACCT) >180 min, and non-use carperitide and multivariate analysis confirmed that ACCT >180 min, and non-use carperitide were risk factor of MACCE.Conclusions: This study showed that the results of conventional AVR in very old patients were not satisfactory. However, the results obtained with isolated AVR were favorable with no operative deaths. The present study demonstrated that preoperative cardiac function, preoperative renal function, and operative factors have an important impact on early mortality and MACCE. 相似文献
13.
14.
Hemangiomas are the most common benign primary tumors of the liver and their prevalence ranges from 0.4% to 20%. Approximately 85% of hemangiomas are clinically asymptomatic and are incidentally detected in imaging studies performed for other causes. In a very small minority of patients, nausea, vomiting, abdominal pain, distension, palpable mass, obstructive jaundice, bleeding, and signs and symptoms of Budd-Chiari syndrome may develop due to compression of bile duct, hepatic vein, portal vein, and adjacent organs. Occasionally, external compression of inferior vena cava may lead to edema and/or indirect symptoms such as deep vein thrombosis of the lower limbs. In this report, we present a case of giant hepatic hemangioma that completely filled the right lobe of the liver. The patient presented with bilateral lower limb edema and pain. A computed tomography scan detected a 9 × 11 × 12 cm mass indicative of a hemangioma in the right lobe of the liver that compressed the inferior vena cava. The patient refused treatment initially but returned 6 months later presenting with the same symptoms. At that time, the mass had increased in size and a hepatectomy was performed, preserving the middle hepatic vein. By postoperative month 13, the swelling in the lower extremities had decreased significantly and the inferior vena cava appeared normal. 相似文献
15.
16.
Keito Suzuki MD Akira Sezai MD PhD Masashi Tanaka MD PhD 《Journal of cardiac surgery》2020,35(1):236-238
Essential thrombocythemia (ET) is a rare condition with an incidence of several persons per million in Japan, while the incidence of thrombosis ranges from 11% to 25%. We present a woman in her 70 seconds with ET who developed small intestinal necrosis and thrombosis in the proximal descending aorta. The patient underwent partial small bowel resection and replacement of the descending aorta, followed by multiple reoperations for thrombotic and hemorrhagic complications. She eventually died of empyema and sepsis caused by Klebsiella oxytoca. In patients with ET and large vessel thrombosis, we have to carefully judge the indications for surgery. 相似文献
17.
18.
Mitsumasa Hata Motomi Shiono Hiroaki Hata Akira Sezai Kenji Akiyama Yukihiko Orime Shinji Wakui 《Surgery today》2014,44(9):1669-1673
Purpose
We assessed the incidence of coronary artery disease (CAD) during hospitalization after emergency surgery for a type A acute aortic dissection.Methods
A total of 123 patients underwent multi-slice computed tomography (MSCT) scans during an early stage after surgery. The patients were divided into two groups: group I consisted of 14 patients (11.4 %) who had coronary artery stenosis of more than 75 % on MSCT, and group II consisted of 109 patients (88.6 %) who had no coronary lesions.Results
The prevalence of diabetes, dyslipidemia and a smoking history was significantly higher in group I. Although the serum low-density lipoprotein cholesterol levels were similar, the high-density lipoprotein cholesterol (HDL) level was significantly lower in group I (36.4 ± 7.9 mg/dl) than in group II (49.6 ± 13.5 mg/dl, P = 0.0005). The maximum carotid intima-media thickness (IMT) was significantly thicker in group I (1.17 ± 0.37 mm) compared to group II (0.96 ± 0.33 mm, P = 0.0297). The logistic regression analysis detected that a carotid IMT over 1.1 mm (odds ratio 4.35, P = 0.0371) and HDL less than 40 mg/dl (odds ratio 3.90, P = 0.0482) were predictors for CAD.Conclusions
CAD screening should be recommended for patients with aortic dissection who have several atherosclerosis risk factors, even after emergency surgery. 相似文献19.
Takashi Nojiri Masayoshi Inoue Kazuhiro Yamamoto Hajime Maeda Yukiyasu Takeuchi Tomoyuki Nakagiri Yasushi Shintani Masato Minami Noriyoshi Sawabata Meinoshin Okumura 《Surgery today》2014,44(2):285-290
Purpose
A new diagnosis of chronic obstructive pulmonary disease is often made during the evaluation of patients requiring lung cancer surgery. The objective of the present study was to evaluate the clinical effects of inhaled tiotropium on the postoperative cardiopulmonary complications in patients with untreated chronic obstructive pulmonary disease requiring lung cancer surgery.Methods
A retrospective study involving 104 consecutive patients with moderate to severe chronic obstructive pulmonary disease who underwent a lobectomy for lung cancer at two specialized thoracic centers between April 2008 and October 2011 was performed. The results were compared between patients who did and did not receive inhaled tiotropium during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. The postoperative white blood cell counts and C-reactive protein levels as biomarkers of inflammation were also examined.Results
The incidence of postoperative cardiopulmonary complications was significantly lower in the tiotropium group than in the control group (18 vs. 48 %, P = 0.001). Patients in the tiotropium group also showed significantly lower white blood cell counts and C-reactive protein levels postoperatively.Conclusions
Inhaled tiotropium treatment during the perioperative period had a prophylactic effect on postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery. 相似文献20.