全文获取类型
收费全文 | 2858篇 |
免费 | 162篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 147篇 |
妇产科学 | 58篇 |
基础医学 | 339篇 |
口腔科学 | 54篇 |
临床医学 | 155篇 |
内科学 | 647篇 |
皮肤病学 | 25篇 |
神经病学 | 145篇 |
特种医学 | 106篇 |
外科学 | 653篇 |
综合类 | 12篇 |
预防医学 | 54篇 |
眼科学 | 101篇 |
药学 | 231篇 |
中国医学 | 31篇 |
肿瘤学 | 272篇 |
出版年
2024年 | 2篇 |
2023年 | 16篇 |
2022年 | 35篇 |
2021年 | 87篇 |
2020年 | 42篇 |
2019年 | 66篇 |
2018年 | 86篇 |
2017年 | 71篇 |
2016年 | 73篇 |
2015年 | 96篇 |
2014年 | 119篇 |
2013年 | 126篇 |
2012年 | 164篇 |
2011年 | 214篇 |
2010年 | 105篇 |
2009年 | 116篇 |
2008年 | 172篇 |
2007年 | 209篇 |
2006年 | 181篇 |
2005年 | 194篇 |
2004年 | 212篇 |
2003年 | 166篇 |
2002年 | 186篇 |
2001年 | 28篇 |
2000年 | 29篇 |
1999年 | 23篇 |
1998年 | 26篇 |
1997年 | 32篇 |
1996年 | 25篇 |
1995年 | 27篇 |
1994年 | 17篇 |
1993年 | 9篇 |
1992年 | 12篇 |
1991年 | 9篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 7篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1976年 | 4篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1956年 | 2篇 |
排序方式: 共有3046条查询结果,搜索用时 11 毫秒
61.
We report on a Japanese boy with Noonan syndrome who had short stature, bilateral cryptorchidism, poor pubertal development, mild mental retardation, complex cardiac lesions consisting of hypertrophic cardiomyopathy, mitral valve stenosis and insufficiency, subvalvular aortic stenosis, and single coronary artery, and various dysmorphic features including hypertelorism, epicanthic folds, low set malrotated ears, high arched palate, micrognathia, webbed neck, low posterior hairline, shield chest, pectus excavatum, cubitus valgus, borderline short metatarsals, lymphedema, redundant skin, and nail dysplasia. Because of marked lymphedema in the bilateral lower legs, lymphatic scintigraphy was carried out at 13.3 years of age, indicating extreme lymphstasis in the lower extremities, severe lymphstasis in the forearm, the elbow, and the axillary regions, moderate lymphstasis around the ascending aorta, and mild lymphstasis in the bilateral lungs. The results, in conjunction with those suggested in Turner syndrome, imply that lymphatic hypoplasia/dysplasia and resultant distended lymphatics and lymphedema are relevant to the development of not only soft tissue and visceral anomalies but also skeletal anomalies in Noonan syndrome. 相似文献
62.
Satoshi Nozaki Aya Mawatari Yuka Nakatani Emi Hayashinaka Yasuhiro Wada Yukihiro Nomura Takahito Kitayoshi Kouji Akimoto Shinji Ninomiya Hisashi Doi Yasuyoshi Watanabe 《Molecular imaging and biology》2018,20(6):1001-1007
Purpose
Thiamine is an essential component of glucose metabolism and energy production. The disulfide derivative, thiamine tetrahydrofurfuryl disulfide (TTFD), is better absorbed than readily-available water-soluble thiamine salts because it does not require the rate-limiting transport system required for thiamine absorption. However, the detailed pharmacokinetics of thiamine and TTFD under normal and pathological conditions have not yet been clarified. C-11-labeled thiamine and TTFD were recently synthesized by our group. In this study, to clarify the differences in pharmacokinetics and metabolism of these probes, a quantitative PET imaging study and radiometabolite analysis of C-11-labeled thiamine and TTFD were performed in the rat heart.Procedures
Positron emission tomography (PET) imaging with [11C]thiamine and [11C]TTFD was performed in normal rats to determine the pharmacokinetics of these probes, and the radiometabolites of both probes from the blood and heart tissue were analyzed by thin-layer chromatography.Results
Accumulation of [11C]TTFD was significantly higher than that of [11C]thiamine in the rat heart. Moreover, as a result of the radiometabolite analysis of heart tissue at 15 min after the injection of [11C]TTFD, thiamine pyrophosphate, which serves as a cofactor for the enzymes involved in glucose metabolism, was found as the major radiometabolite and at a significantly higher level than in the [11C]thiamine-injected group.Conclusions
PET imaging techniques for visualizing the kinetics and metabolism of thiamine using [11C]thiamine and [11C]TTFD were developed in this study. Consequently, noninvasive PET imaging for the pathophysiology of thiamine-related cardiac function may provide novel information about heart failure and related disorders.63.
Akira Yamashita Tetsuo Maeda Yasuhiro Myojo Yukihiro Wato Keisuke Ohta Hideo Inaba 《The American journal of emergency medicine》2018,36(12):2203-2210
Purpose
To investigate temporal variations in dispatcher-assisted and bystander-initiated resuscitation efforts and their association with survival after bystander-witnessed out-of-hospital cardiac arrests (OHCAs).Methods
We retrospectively analyzed the neurologically favorable 1-month survival and the parameters related to dispatcher assisted cardiopulmonary resuscitation (DA-CPR) and bystander CPR (BCPR) for 227,524 OHCA patients between 2007 and 2013 in Japan. DA-CPR sensitivity for OHCAs, bystander's compliance to DA-CPR assessed by the proportion of bystanders who follow DA-CPR, and performance of BCPR measured by the rate of bystander-initiated CPR in patients without DA-CPR were calculated as indices of resuscitation efforts.Results
Performance of BCPR was only similar to temporal variations in the survival (correlation between hourly paired values, R2 = 0.263, P = 0.01): a lower survival rate (3.4% vs 4.2%) and performance of BCPR (23.1% vs 30.8%) during night-time (22:00–5:59) than during non-night-time. In subgroup analyses based on interaction tests, all three indices deteriorated during night-time when OHCAs were witnessed by non-family (adjusted odds ratio, 0.73–0.82), particularly in non-elderly patients. The rate of public access defibrillation for these OHCAs markedly decreased during night-time (adjusted odds ratio, 0.49) with delayed emergency calls and BCPR initiation. Multivariable logistic regression analyses revealed that the survival rate of non-family-witnessed OHCAs was 1.83-fold lower during night-time than during non-night-time.Conclusions
Dispatcher-assisted and bystander-initiated resuscitation efforts are low during night-time in OHCAs witnessed by non-family. A divisional alert system to recruit well-trained individuals is needed in order to improve the outcomes of night-time OHCAs witnessed by non-family bystanders. 相似文献64.
65.
Genda Takuya Ichida Takafumi Tanaka Eiji Mochida Satoshi Ueno Yoshiyuki Terai Shuji Inui Ayano Ueda Yoshihide Ohdan Hideki Egawa Hiroto Umeshita Koji Furukawa Hiroyuki Inomata Yukihiro 《Journal of gastroenterology》2022,57(7):495-504
Journal of Gastroenterology - Following liver transplantation (LT), allograft liver failure can be developed by various causes and requires re-LT. Hence, this study aimed to clarify the... 相似文献
66.
67.
Yukihiro Sugimoto Hiroshi Semba Shinji Fujii Eri Furukawa Ryouichi Kurano 《Nihon Kokyūki Gakkai zasshi》2007,45(6):460-464
We report 8 rare cases of primary lung cancer which showed a thin-walled cavity on chest X-ray and CT. We analyzed 8 cases (7 men, 1 woman) of primary lung cancer with thin-walled cavities admitted to our hospital between 1995 and 2006. The subjects were aged between 45 and 84 years of age (median: 72 years old). The reason for detection was treatment for tuberculosis in 1 case, ileus owing to metastasis to the small intestine in 1 case and tension pnumathorax 1 case, while 5 cases had abnormal chest x-ray film shadows without symptoms. Histologically, there were 5 cases of adenocarcinoma, 2 of squamous cell carcinoma, and 1 of adenosquamous cell carcinoma. Though various reports on the mechanism of the development of thin-walled cavity formation have been made, we suggest that it mainly develops by a check-valve mechanism, based on evaluation of the clinical course. 相似文献
68.
Clinical Significance of Fasting Serum Bile Acid in the Long-Term Observation of Chronic Liver Disease 总被引:4,自引:0,他引:4
Yukihiro Kishimoto Satoshi Hijiya Isamu Takeda 《The American journal of gastroenterology》1985,80(2):136-138
Fasting serum bile acid (FSBA) was serially measured by a fluorescent enzyme method in a follow-up study of 61 patients with chronic liver disease. In chronic inactive hepatitis, fluctuation of FSBA was within the normal range in both the exacerbated state and in remission. In chronic active hepatitis, FSBA was abnormally elevated in both states, but the difference was not significant. In chronic active hepatitis where FSBA was elevated in the remission state above its value in the exacerbated state, exacerbation of the disease occurred repeatedly during the follow-up period. In compensated liver cirrhosis progressing into the decompensated form, FSBA levels increased before a decrease in the serum values of albumin, cholesterol, and cholinesterase, and an elevation of bilirubin. In liver cirrhosis, FSBA levels increased above 100 microM, 1-4 months before the appearance of ascites. 相似文献
69.
Yoshimoto S Hirooka K Irino H Abe H Yasuoka Y Yamamoto H Hashimoto K Chin W Koretsune Y Kusuoka H Yasumura Y 《Japanese heart journal》2004,45(4):679-683
This report describes a patient with a single coronary artery in whom the right coronary artery originated from the distal left circumflex artery. Single coronary artery is a rare congenital anomaly of the coronary circulation which is often associated with other congenital cardiac malformations. This anomaly is thought to be clinically significant especially in patients with atrial fibrillation, although no other associated cardiac anomaly was detected. 相似文献
70.
Masashi Takahashi Junya Fukuoka Norihisa Nitta Ryutaro Takazakura Yukihiro Nagatani Yoko Murakami Hideji Otani Kiyoshi Murata 《INT J CHRONIC OBSTR》2008,3(2):193-204
The term ‘emphysema’ is generally used in a morphological sense, and therefore imaging modalities have an important role in diagnosing this disease. In particular, high resolution computed tomography (HRCT) is a reliable tool for demonstrating the pathology of emphysema, even in subtle changes within secondary pulmonary lobules. Generally, pulmonary emphysema is classified into three types related to the lobular anatomy: centrilobular emphysema, panlobular emphysema, and paraseptal emphysema. In this pictorial review, we discuss the radiological – pathological correlation in each type of pulmonary emphysema. HRCT of early centrilobular emphysema shows an evenly distributed centrilobular tiny areas of low attenuation with ill-defined borders. With enlargement of the dilated airspace, the surrounding lung parenchyma is compressed, which enables observation of a clear border between the emphysematous area and the normal lung. Because the disease progresses from the centrilobular portion, normal lung parenchyma in the perilobular portion tends to be preserved, even in a case of far-advanced pulmonary emphysema. In panlobular emphysema, HRCT shows either panlobular low attenuation or ill-defined diffuse low attenuation of the lung. Paraseptal emphysema is characterized by subpleural well-defined cystic spaces. Recent topics related to imaging of pulmonary emphysema will also be discussed, including morphometry of the airway in cases of chronic obstructive pulmonary disease, combined pulmonary fibrosis and pulmonary emphysema, and bronchogenic carcinoma associated with bullous lung disease. 相似文献