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Conventional hemorrhoidectomy is applied for the treatment of prolapsing internal hemorrhoids. Recently, less-invasive treatments such as sclerotherapy using aluminum potassium sulphate/tannic acid (ALTA) and a procedure for prolapse and hemorrhoids (PPH) have been introduced. We compared the results of sclerotherapy with ALTA and an improved type of PPH03 with those of hemorrhoidectomy. Between January 2006 and March 2009, we performed hemorrhoidectomy in 464 patients, ALTA in 940 patients, and PPH in 148 patients with second- and third-degree internal hemorrhoids according to the Goligher''s classification. The volume of ALTA injected into a hemorrhoid was 7.3 ± 2.2 (mean ± SD) mL. The duration of the operation was significantly shorter in ALTA (13 ± 2 minutes) than in hemorrhoidectomy (43 ± 5 minutes) or PPH (32 ± 12 minutes). Postoperative pain, requiring intravenous pain medications, occurred in 65 cases (14%) in hemorrhoidectomy, in 16 cases (1.7%) in ALTA, and in 1 case (0.7%) in PPH. The disappearance rates of prolapse were 100% in hemorrhoidectomy, 96% in ALTA, and 98.6% in PPH. ALTA can be performed on an outpatient basis without any severe pain or complication, and PPH is a useful alternative treatment with less pain. Less-invasive treatments are beneficial when performed with care to avoid complications. 相似文献
44.
Rin Asao Katsuhiko Asanuma Fumiko Kodama Miyuki Akiba-Takagi Yoshiko Nagai-Hosoe Takuto Seki Yukihiko Takeda Isao Ohsawa Satoshi Mano Kiyoshi Matsuoka Hiroyuki Kurosawa Shinya Ogasawara Yoshiaki Hirayama Sakari Sekine Satoshi Horikoshi Masanori Hara Yasuhiko Tomino 《Clinical journal of the American Society of Nephrology》2012,7(9):1385-1393
45.
Yukihiko Hiroshima Fumio Nakamura Hiroshi Miyamoto Ryutaro Mori Koichi Taniguchi Ryusei Matsuyama Hirotoshi Akiyama Kuniya Tanaka Yasushi Ichikawa Shingo Kato Noritoshi Kobayashi Kensuke Kubota Yoji Nagashima Yoshio Goshima Itaru Endo 《Annals of surgical oncology》2013,20(3):369-378
Background
Pancreatic cancer is an aggressive malignancy with one of the worst mortality rates of all cancers. Recently, collapsin response mediator proteins (CRMPs) were reported to be associated with proliferation, apoptosis, differentiation, and invasion in several cancers. However, CRMP expression and their role in pancreatic cancer have not been investigated. This study aimed to clarify the clinical significance of CRMPs in pancreatic cancer.Methods
Expression of crmp genes in 11 pairs of pancreatic cancer and corresponding noncancerous pancreas tissues were examined by real-time RT-PCR. Knockdown of CRMP4 expression using siRNA was examined in pancreatic cancer cell lines to determine whether CRMP4 regulates cell proliferation and invasion in vitro. Furthermore, CRMP4 protein levels in primary tumors of pancreatic cancer (n = 53) were examined by immunohistochemistry and compared with the clinicopathological features of the tumors.Results
Of all the CRMPs, only CRMP4 was differentially expressed in pancreatic cancer tissues (p = 0.008). CRMP4 knockdown using siRNA reduced cellular invasion, but did not affect proliferation. The expression of CRMP4 was detected immunohistochemically in 34 (64.2 %) of the 53 pancreatic cancer samples, and CRMP4 expression was correlated with severe venous invasion (p = 0.044), stage (p = 0.019), and liver metastasis (p = 0.021). Multivariate analyses suggested that venous invasion and CRMP4 overexpression were prognostic factors for survival.Conclusions
Our results suggested that CRMP4 is significantly associated with poor prognosis by promoting liver metastasis and can serve as a novel therapeutic target for pancreatic cancer.46.
Marisa Iborra Belén Beltrán Agnes Fernández-Clotet Eva Iglesias-Flores Pablo Navarro Montserrat Rivero Ana Gutiérrez Mónica Sierra-Ausin Francisco Mesonero Rocío Ferreiro-Iglesias Joaquín Hinojosa Xavier Calvet Beatriz Sicilia Carlos González-Muñoza Beatriz Antolín María González-Vivo Ana Y. Carbajo Santiago García-López Albert Martín-Cardona Gerard Surís María Dolores Martin-Arranz Ruth de Francisco Fiorella Cañete Eugeni Domènech Pilar Nos GETECCU group 《Alimentary pharmacology & therapeutics》2020,52(6):1017-1030
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48.
Mitsumasa Hata Motomi Shiono Hiroaki Hata Akira Sezai Kenji Akiyama Yukihiko Orime Shinji Wakui 《Surgery today》2014,44(9):1669-1673
Purpose
We assessed the incidence of coronary artery disease (CAD) during hospitalization after emergency surgery for a type A acute aortic dissection.Methods
A total of 123 patients underwent multi-slice computed tomography (MSCT) scans during an early stage after surgery. The patients were divided into two groups: group I consisted of 14 patients (11.4 %) who had coronary artery stenosis of more than 75 % on MSCT, and group II consisted of 109 patients (88.6 %) who had no coronary lesions.Results
The prevalence of diabetes, dyslipidemia and a smoking history was significantly higher in group I. Although the serum low-density lipoprotein cholesterol levels were similar, the high-density lipoprotein cholesterol (HDL) level was significantly lower in group I (36.4 ± 7.9 mg/dl) than in group II (49.6 ± 13.5 mg/dl, P = 0.0005). The maximum carotid intima-media thickness (IMT) was significantly thicker in group I (1.17 ± 0.37 mm) compared to group II (0.96 ± 0.33 mm, P = 0.0297). The logistic regression analysis detected that a carotid IMT over 1.1 mm (odds ratio 4.35, P = 0.0371) and HDL less than 40 mg/dl (odds ratio 3.90, P = 0.0482) were predictors for CAD.Conclusions
CAD screening should be recommended for patients with aortic dissection who have several atherosclerosis risk factors, even after emergency surgery. 相似文献49.
Katsunobu Tsuneoka Yukihiko Tameda Koujirou Takase Takeshi Nakano 《Journal of gastroenterology》1996,31(5):669-678
Bone mineral density (BMD) of the lumber vertebrae and factors related to bone metabolism were determined in patients with
chronic viral hepatitis and patients with liver cirrhosis to clarify correlations between hepatic dysfunction, considered
to be one of the causes of hepatic osteodystrophy, and decrease in bone mass. BMD of the second to fourth lumbar vertebrae
was determined with a Lunar (Madison, WI, USA) DPX, a dual-energy X-ray absorptiometry diagnostic system. BMD was significantly
lowest in patients with liver cirrhosis, followed by patients with chronic hepatitis, and healthy subjects, in this order.
There was a significantly positive but weak correlation between albumin and BMD. Levels of 25(OH)D and 1,25(OH)2D were significantly lower in patients with liver cirrhosis than in those with chronic hepatitis. BMD and vitamin D were decreased
in all patients whose cholinesterase (ChE) was below 0.3ΔpH. Urinary pyridinoline(Upyr) was significantly higher in the patients
with liver cirrhosis, in whom bone mass was decreased, than in the patients with chronic hepatitis, whereas serum osteocalcin
levels were distributed in the upper normal range in patients with chronic hepatitis and those with liver cirrhosis. There
was a positive correlation between 25(OH)D and serum osteocalcin levels in patients with liver cirrhosis. These results indicate
that osteogenesis is decreased and suggest that the decrease in BMD which occurs in viral liver cirrhosis, probably related
to decreased, bone formation and slight promotion of bone resorption, reflects deranged hepatic function. This is the first
report of Upyr and urinary deoxypyridinoline (UDpyr) determination in patients with liver cirrhosis and patients with chronic
hepatitis. The negative correlation of Upyr and UDpyr with ChE is a novel finding. 相似文献
50.
Autoimmunity causes pathological conditions resulting in autoimmune diseases (ADs). Although autoimmunity is a mystery, immunological dogma suggests that autoreactive cell reactivation (ACR) breaks self-tolerance and induces autoimmunity. Thus, ACR is a royal pathway for ADs. Cumulative evidence implicates environmental factors as secondary triggers of ADs in the genetically susceptible hosts. Infection is the most likely trigger. Although several mechanisms have been proposed to explain how infectious agents trigger ADs, ACR is assumed to be an essential pathway. 相似文献