Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis.

A genome-wide screen was conducted using a large white sample to identify QTLs for FNCS geometry. We found significant linkage of FNCS parameters to 20q12 and Xq25, plus significant epistatic interactions and sex-specific QTLs influencing FNCS geometry variation. INTRODUCTION: Bone geometry, a highly heritable trait, is a critical component of bone strength that significantly determines osteoporotic fracture risk. Specifically, femoral neck cross-sectional (FNCS) geometry is significantly associated with hip fracture risk as well as genetic factors. However, genetic research in this respect is still in its infancy. MATERIALS AND METHODS: To identify the underlying genomic regions influencing FNCS variables, we performed a remarkably large-scale whole genome linkage scan involving 3998 individuals from 434 pedigrees for four FNCS geometry parameters, namely buckling ratio (BR), cross-sectional area (CSA), cortical thickness (CT), and section modulus (Z). The major statistical approach adopted is the variance component method implemented in SOLAR. RESULTS: Significant linkage evidence (threshold LOD = 3.72 after correction for tests of multiple phenotypes) was found in the regions of 20q12 and Xq25 for CT (LOD = 4.28 and 3.90, respectively). We also identified eight suggestive linkage signals (threshold LOD = 2.31 after correction for multiple tests) for the respective geometry traits. The above findings were supported by principal component linkage analysis. Of them, 20q12 was of particular interest because it was linked to multiple FNCS geometry traits and significantly interacted with five other genomic loci to influence CSA variation. The effects of 20q12 on FNCS geometry were present in both male and female subgroups. Subgroup analysis also revealed the presence of sex-specific quantitative trait loci (QTLs) for FNCS traits in the regions such as 2p14, 3q26, 7q21 and 15q21. CONCLUSIONS: Our findings laid a foundation for further replication and fine-mapping studies as well as for positional and functional candidate gene studies, aiming at eventually finding the causal genetic variants and hidden mechanisms concerning FNCS geometry variation and the associated hip fractures.     

Intravenous Gammaglobulin (IVIG): A Novel Approach to Improve Transplant Rates and Outcomes in Highly HLA-Sensitized Patients

Intravenous immunoglobulin (IVIG) products are derived from pooled human plasma and have been used for the treatment of primary immunodeficiency disorders for more than 24 years. Shortly after their introduction, IVIG products were also found to be effective in the treatment of autoimmune and inflammatory disorders. Over the past 2 decades, the list of diseases where IVIG has a demonstrable beneficial effect has grown rapidly. These include Kawasaki disease, Guillain-Barre syndrome, myasthenia gravis, dermatomyositis and demyelinating polyneuropathy. Recently, we have described a beneficial effect on the reduction of anti-HLA antibodies with subsequent improvement in transplantation of highly HLA-sensitized patients as well as a potent anti-inflammatory effect that is beneficial in the treatment of antibody-mediated rejection (AMR). These advancements have enabled transplantation of patients previously considered untransplantable. These studies and relevant mechanism(s) of action will be discussed here.     

录像脑电图对癫痫治疗撤药的指导价值

目的 观察3年无发作癫痫患者停药前脑电图异常率，并指导停药。方法 对26例无发作患者在停药前实施录像脑电监护。结果 26例病人中，9例发现异常，而且这些异常大多出现在睡眠期和病史较长、多药联合治疗和全面性发作的患者。结论 癫痫患者停药前实施录像脑电图监护是必要的。     

LEEP刀治疗与护理相结合治疗宫颈疾病的作用

目的探讨LEEP刀治疗与护理相结合在治疗宫颈疾病中的作用。方法选择应用LEEP刀治疗与红外光治疗两组患者各60例。比较其疗效和护理作用。结果LEEP刀治疗比红外光治疗宫颈疾病效果要好。结论LEEP刀治疗与护理相结合对宫颈疾病的治疗值得推广应用。     

Effects of Activated Complement on Lung Fluid Exchange in Conscious Goats:Role of Superoxide Anion

The effects of zymosan-activated plasma(ZAP)on lung fluid exchangeand on superoxide anion production by granulocytes were studied in 8 consciousgoats with chronic lung lymph fistula,It was found that after ZAP infusion, thecirculating granulocytes were activated and the release of superoxide anions wasmarkedly enhanced. There was an increase in lung lymph flow and proteinconcentration.It suggests that the superoxide anion released by the stimulatedgranulocytes can play a role in inducing lung injury by the activated complement.     

血液透析对慢性肾功能衰竭患者血浆心钠素水平的影响

本文观察了15例慢性肾功能衰竭病人透析前后的血浆心钠素浓度改变.患者透析前血浆心钠素浓度较正常人明显增高(P相似文献   

羊踯躅根治疗慢性肾小球肾炎的实验及临床研究

本文用反复静脉注射小剂量牛血清白蛋白复制家兔慢性肾炎,用羊踯躅根治疗。同时,用该药对慢性肾炎病人进行疗效观察。阳性组兔肾小球呈现中至重度颗粒形免疫荧光,肾组织呈明显慢性硬化性肾小球肾炎改变。尿蛋白±～++。治疗组兔及病人治疗后病变及症状均明显减轻或消失。结果提示循环免疫复合物反复沉着可引起兔类似人类的慢性硬化性肾小球肾炎,羊踯躅根对病变有一定的控制和治疗作用,这可能与其抑制免疫发病机制有关。     

番荔枝开花生物学与人工授粉研究

对三年生番荔枝（Ancnona squamosa L.)实生树的开花生物学和人工授粉进行了研究并发现；番荔枝的花有两荔异熟现象，人工授粉能提高座果率，简便而有效的方法是用毛笔直接从树上花药自然裂开的花上聚花粉并立即授在花药没裂开的花上，授粉后两周的座果率达87．9％，授 在花药裂开的花上，座果率为5．3％，与对照照座果率4．4％没有区别，说明花药裂开柱头容受性完全消失，花药裂开时间与品种特有关，目前，广东栽培的番荔枝分为花药早上裂开和傍开两种类型，这两种类型的不同品种之间授粉也能提高座果率，授粉后两周的座果率为83．3％。说明花裂开关12h柱头容受性仍完全正常。     

51例早孕妇女绒毛超氧化物歧化酶测定结果分析

本文采用改良的邻革之酚自氧化法,对51例无遗传性疾病早孕妇女绒毛细胞进行了SOD活力测定。其比活力为426.2±48.4u/mg蛋白(x±SD),测定值范围为217.2～589.1u/mg蛋白,P95>915.0u/mg蛋白。