全文获取类型
收费全文 | 514051篇 |
免费 | 82844篇 |
国内免费 | 25592篇 |
专业分类
耳鼻咽喉 | 5443篇 |
儿科学 | 10182篇 |
妇产科学 | 7739篇 |
基础医学 | 66861篇 |
口腔科学 | 14543篇 |
临床医学 | 68563篇 |
内科学 | 88126篇 |
皮肤病学 | 12135篇 |
神经病学 | 34571篇 |
特种医学 | 17918篇 |
外国民族医学 | 176篇 |
外科学 | 59124篇 |
综合类 | 70359篇 |
现状与发展 | 89篇 |
一般理论 | 86篇 |
预防医学 | 36991篇 |
眼科学 | 12517篇 |
药学 | 50945篇 |
364篇 | |
中国医学 | 24331篇 |
肿瘤学 | 41424篇 |
出版年
2024年 | 1605篇 |
2023年 | 7136篇 |
2022年 | 15985篇 |
2021年 | 21797篇 |
2020年 | 20542篇 |
2019年 | 22900篇 |
2018年 | 23583篇 |
2017年 | 24019篇 |
2016年 | 23916篇 |
2015年 | 29776篇 |
2014年 | 34980篇 |
2013年 | 35255篇 |
2012年 | 36393篇 |
2011年 | 39187篇 |
2010年 | 32668篇 |
2009年 | 25573篇 |
2008年 | 26414篇 |
2007年 | 25158篇 |
2006年 | 23969篇 |
2005年 | 22333篇 |
2004年 | 16322篇 |
2003年 | 15096篇 |
2002年 | 13133篇 |
2001年 | 11718篇 |
2000年 | 10706篇 |
1999年 | 9939篇 |
1998年 | 5924篇 |
1997年 | 6075篇 |
1996年 | 4673篇 |
1995年 | 4235篇 |
1994年 | 3671篇 |
1993年 | 2564篇 |
1992年 | 3463篇 |
1991年 | 3061篇 |
1990年 | 2606篇 |
1989年 | 2363篇 |
1988年 | 2037篇 |
1987年 | 1872篇 |
1986年 | 1573篇 |
1985年 | 1276篇 |
1984年 | 942篇 |
1983年 | 786篇 |
1982年 | 581篇 |
1981年 | 503篇 |
1980年 | 435篇 |
1979年 | 486篇 |
1978年 | 375篇 |
1977年 | 375篇 |
1976年 | 324篇 |
1974年 | 298篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
41.
42.
43.
Julie Despres Yasmina Ramdani Marine di Giovanni Magalie Bnard Abderrakib Zahid Mait Montero‐Hadjadje Florent Yvergnaux Thibaut Saguet Azeddine Driouich Marie‐Laure Follet‐Gueye 《Experimental dermatology》2019,28(8):922-932
It is well recognized that the world population is ageing rapidly. Therefore, it is important to understand ageing processes at the cellular and molecular levels to predict the onset of age‐related diseases and prevent them. Recent research has focused on the identification of ageing biomarkers, including those associated with the properties of the Golgi apparatus. In this context, Golgi‐mediated glycosylation of proteins has been well characterized. Additionally, other studies show that the secretion of many compounds, including pro‐inflammatory cytokines and extracellular matrix–degrading enzymes, is modified during ageing, resulting in physical and functional skin degradation. Since the Golgi apparatus is a central organelle of the secretory pathway, we investigated its structural organization in senescent primary human dermal fibroblasts using confocal and electron microscopy. In addition, we monitored the expression of Golgi‐related genes in the same cells. Our data showed a marked alteration in the Golgi morphology during replicative senescence. In contrast to its small and compact structure in non‐senescent cells, the Golgi apparatus exhibited a large and expanded morphology in senescent fibroblasts. Our data also demonstrated that the expression of many genes related to Golgi structural integrity and function was significantly modified in senescent cells, suggesting a relationship between Golgi apparatus function and ageing. 相似文献
44.
Jakub Pazdrowski Aleksandra Daczak‐Pazdrowska Adriana Polaska Joanna Ka
mierska Wojciech Barczak Mateusz Szewczyk Pawe Golusiski Zygmunt Adamski Ryszard aba Wojciech Golusiski 《Skin research and technology》2019,25(6):857-861
Radiodermatitis is one of the commonest side effects of radiotherapy. They are usually assessed by semi‐quantitative clinical scores, which are not validated and may be subject to inter‐observer variability. A few previous studies suggested that high‐frequency ultrasonography (HF‐USG) is useful in the assessment of the acute phase of radiation dermatitis in breast cancer patients. (a) To monitor skin changes by HF‐USG during the course of radiotherapy due to head and neck cancers, and (b) to determine whether there is any connection between skin sonograms and the skin scoring criteria. This prospective, observational study includes patients diagnosed with head and neck cancers, treated with radiotherapy or concomitant chemoradiation. The final analysis includes six patients. In every patient, the HF‐USG as well as dermatological assessment (target lesion score—TLS and CACE v. 4.0) were performed 4×: before, in the middle, day after, and 3 months after radiotherapy. There were significant differences between non‐irradiated skin thickness and thickness of skin with clinically obvious radiodermatitis (TLS grade 1‐4; P < .0001), as well as between irradiated, unchanged skin thickness (TLS grade 0) and thickness of skin with clinically obvious radiodermatitis (TLS grade 1‐4; P = .0002). There was no significant difference between non‐irradiated and irradiated, unchanged skin thickness (TLS grade 0; P = .9318). In four patients, we demonstrated subepidermal low echogenic band (SLEB). HF‐USG can be useful tool to noninvasive and objective assessment of skin changes during radiotherapy. 相似文献
45.
Jean‐Franois Etter 《Addiction (Abingdon, England)》2019,114(12):2252-2256
46.
47.
Stepanova E. S. Makarenkova L. M. Chistyakov V. V. Rybakov Yu. L. Gukasov V. M. Fedotcheva T. A. Parshin V. A. Votyakov V. A. Shimanovskii N. L. 《Pharmaceutical Chemistry Journal》2019,52(12):1016-1020
Pharmaceutical Chemistry Journal - An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was... 相似文献
48.
49.
背景 慢性阻塞性肺疾病(COPD)患者肺栓塞(PE)发生率显著高于常人,但目前不伴红细胞增多的COPD患者并发PE的机制尚不明确。目的 探讨不伴红细胞增多的COPD患者并发PE的影响因素。方法 本研究为回顾性病例对照研究。收集2017年1-12月在新疆医科大学第一附属医院呼吸与呼吸危重症中心住院治疗的血红蛋白(Hb)≤140 g/L的COPD患者。依据肺多层螺旋CT肺血管成像(CTPA)检查结果将患者分为并发PE组和单纯COPD组。记录患者的年龄、性别、合并症、服用抗血小板或抗凝药物史。采用倾向性评分匹配(PSM)方法,通过二元Logistic回归分析估计倾向性评分值,采用1∶1最邻近原则匹配,卡钳值为0.05,筛选出基线相同的两组病例。记录患者的D-二聚体、血常规检查结果,比较两组间差异;分析不伴红细胞增多的COPD患者并发PE的影响因素,红细胞分布宽度(RDW)与中性粒细胞/淋巴细胞比值(NLR)的相关性。结果 共纳入病例339例,其中单纯COPD组289例,并发PE组50例。采用PSM方法筛选两组患者,最终得到单纯COPD组、并发PE组各50例进行后续研究。并发PE组患者D-二聚体、中性粒细胞计数(N)、RDW、NLR高于单纯COPD组,淋巴细胞计数(L)低于单纯COPD组(P<0.05)。二元Logistic回归分析结果显示,RDW是不伴红细胞增多的COPD患者并发PE的影响因素〔OR=1.561,95%CI(1.096,2.225),P<0.05〕。Spearman秩相关分析结果显示,不伴红细胞增多的COPD患者RDW与NLR呈正相关(rs=0.225,P<0.05)。结论 RDW升高是Hb≤140 g/L的COPD患者并发PE的危险因素,且RDW与NLR呈正相关。 相似文献
50.