箭叶淫羊藿叶水提取液抗心律失常作用的研究

目的：了解箭叶淫羊藿叶（Epimedium Breuicornum Maxin EBM)水提取液的抗心律失常作用。方法：常规抗心律失常的方法。结果：箭叶淫羊藿叶水提取液对氯仿诱发的小鼠室颤，氯化钙诱发的大鼠室颤均有明显的预防作用，对乌头碱诱发的大鼠心律失常有明显的治疗效果。但不能对抗肾上腺素诱发的家兔心律失常。箭叶淫羊藿叶水提取液可降低蟾蜍离体坐骨神经动作电位。结论：提示箭叶淫羊藿叶水提取液抗心律失常作用可能与其抑制Na^ ,Ca^2 内流有关。进一步提示箭叶淫羊藿叶水提取液抗心律失常作用可能与其抑制Na^ ，内流有关。而与阻断β－肾上腺素受体无关。     

NSE与视频脑电图在儿童热性惊厥的相关性研究

Objective: To evaluate the diagnostic value of serum neuron specific enolase and Video EEG inFebrile Convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day afterseizure in 40 children with simple febrile convulsion and 18 with complex febrile convulsion. Video EEG was per-formed at 1st, 7th and 30th day in all the patients. Results: There were significant differences between NSE levels at24th hour and on 7th day after convulsion (P<0.01). NSE concentrations in patients with SFC and CFC were also     

曲美他嗪治疗稳定性心绞痛临床观察

目的 :观察曲美他嗪治疗稳定性心绞痛的临床疗效。方法 :观察曲美他嗪治疗 (60mg/d)前后 3 4例稳定性心绞痛病人的心绞痛发作次数、硝酸甘油消耗量、运动试验结果、静息心电图、心率及血压。结果 :曲美他嗪治疗后稳定性心绞痛病人的心绞痛发作次数、硝酸甘油消耗量、总运动时间及静息心电图均较治疗前明显改善 (P <0 .0 1) ;心率及血压无明显变化。结论 :曲美他嗪可改善接受常规治疗的稳定性心绞痛病人的临床表现     

益糖宁对大鼠实验性2型糖尿病的研究

目的 :探讨补肾活血中药益糖宁冲剂对糖尿病大鼠体重、血糖、甘油三酯及 C肽的影响。方法 :健康 SD大鼠 5 0只 ,雄性 ,共分七组 ,分别为正常对照组 ,高脂组 ,高、中、低剂量中药组 ,降糖舒组和模型组。治疗 4周后于禁食 1 2 h采血测定血糖、甘油三酯、C肽、SOD( superoyade,SOD) ,2 h后再测定餐后血糖、餐后 C肽。结果 :糖尿病大鼠普遍存在高血糖、高甘油三酯血症及空腹 C肽低下。高、中剂量组餐后 2 h C肽水平增高至接近正常水平 ( P>0 .0 5 ) ,低剂量组、降糖舒组和模型组餐后 2 h C肽仍低下 ,与正常组比较仍具显著性意义 ( P<0 .0 5 )。高剂量组空腹血糖与其他组比较P<0 .0 5。各糖尿病大鼠较正常组 SOD不同程度下降 ,高、中剂量益糖宁冲剂 SOD与正常组比较P>0 .0 5。结论 :益糖宁冲剂能改善糖尿病大鼠症状 ,具有一定降糖作用 ,且能提高 C肽和 SOD水平     

230例打鼾患者多导睡眠图分析

目的　探讨多导睡眠图 (PSG)对睡眠呼吸暂停综合征 (SAS)的诊断价值及睡眠呼吸暂停综合征 (SAS)对睡眠结构、血氧、心血管系统的影响。方法　对 2 30例打鼾患者进行多导睡眠图监测。结果　 2 30例诊断SAS10 8例 (46 9% ) ,单纯鼾症 (SS) 12 2例 ,SAS与SS组两组相比在睡眠结构、呼吸紊乱、血氧、心血管系统变化等差异有显著性。结论　PSG是诊断SAS、判定病情程度、指导治疗的一种良好方法     

Comparison of Family clinic Community Health Service Model with State—owned Community Health Service Model

Based on a survey of community health service organization in several cities,community health service model based on the family clinic was compared with state-owned community health service model,and status quo,advantages and problems of family community health service organization were analyzed.Furthermore,policies for the management of community health service organization based on the family clinic were put forward.     

Invasion of the skull base by carcinomas: histopathologically evidenced findings with CT and MRI

The depth and extent of the invasion of the skull base by a tumor are the most critical information for successful en bloc resection of the tumor. The only means available for the evaluation of these factors are CT or MRI images. In order to clarify the ability of these imaging modes to delineate the invasion of the skull base, preoperative images of ten patients who underwent en bloc resection of skull base tumors at Kobe University Hospital were compared with the histopathological findings of the resected specimens. CT proved to be superior to MRI for evaluating bone destruction of the skull base. On the other hand, MRI provided more useful information about intracranial invasion than CT. As a hypertrophic linear shadow on Gd-enhanced MRI represented dural invasion or thickened dura mater adjacent to the tumor, this technique should be taken into consideration to determine the dural resection. We concluded that preoperative evaluation of the depth of skull base invasion by both CT and Gd-enhanced MRI is essential for planning complete tumor resection.     

HPLC/MS Determination of Enalapril and Enalaprilat in the Blood Plasma

A reproducible and sensitive analytical procedure has been developed for the quantitative determination of enalapril and enalaprilat in the blood plasma by high-performance liquid chromatography with mass-spectrometric detection (HPLC/MS). For increasing the sensitivity and reproducibility of analyses, the samples were treated with diazomethane in order to obtain methyl esters of the analyzed compounds. The quantitative determination was carried out using the internal standard method; the internal standard was captopril. The detection was performed in the positive ion mode for ions with m/z = 377 (enalaprilat methyl ester), 391 (enalapril methyl ester), and 267 (captopril methyl ester). Enalapril, enalaprilat, and captopril were isolated from the blood plasma and purified by means of solid-phase extraction. The calibration plot is linear in the concentration range from 0.5 to 200 ng/ml. The detection limits for both enalaprilat and enalapril in the blood plasma are 0.1 ng/ml.__________Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 2, pp. 49 – 52, February, 2005.