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Hamada M. M. Sayed Ahmed Mahmoud Youssef Youssef M. Mosaad 《Clinical rheumatology》2010,29(11):1237-1243
Rheumatoid arthritis (RA) patients have increased mortality largely as a result of cardiovascular diseases (CVD) that cannot
be explained by traditional risk factors, suggesting that systemic inflammation may accelerate atherosclerosis. We investigated
the presence of subclinical atherosclerosis in early RA (<12 months) and the possible association of RA-related risk factors.
Forty patients with early RA and 40 controls matched for age, sex, and traditional risk factors for CVD were selected. Carotid
US examination, assay of lipogram, C-reactive protein (CRP), and oxidized low-density lipoprotein antibodies (OxLDL-ab) were
done. RA patients had significantly higher carotid intima-media thickness (cIMT) values and more plaque than the control (P < 0.001 and P = 0.0122, respectively). CRP and OxLDL-ab were significantly higher in RA patients than controls. Traditional risk factors
and RA-related risk factors (disease duration, DAS-28, duration of treatment with steroids, erythrocyte sedimentation rate,
and CRP) as well as OxLDL and cIMT were significantly higher in RA with plaques compared to those without plaques. Regression
analysis identified the age of patients, CRP, and OxLDL-ab as an independent risk factor associated with the presence of atherosclerosis.
Conclusion: there is increased prevalence of carotid plaques in patients with recent-onset RA compared to matched controls.
The accelerated atherosclerosis is predicted by age, CRP, and oxLDL-ab. The association of plaques with elevated CRP and OxLDL-ab
support the hypothesis that chronic systemic autoimmune inflammatory process is probably a driving force for premature atherosclerosis. 相似文献
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Rima Moghnieh Dania Abdallah Lyn Awad Tamima Jisr Anas Mugharbil Ali Youssef Hani Tamim Samer Khaldieh Oula Massri Najat Rashini Youssef Hamdan Ahmad Ibrahim 《Infection》2018,46(6):823-835
Purpose
In this study, we assessed the incidence, contributing factors and outcome of prolonged neutropenia above 7 days and of bacteraemia in patients with lymphoma and multiple myeloma who underwent autologous haematopoietic stem cell transplantation (AHSCT) without antibacterial prophylaxis.Methods
This is a retrospective chart review of 190 adult patients who underwent AHSCT between 2005 and 2015 at a Lebanese hospital.Results
Neutropenia of 7 days duration and longer was documented in 66% of the patient population. Through univariate analysis, patients with lymphoma were significantly more likely to have prolonged neutropenia (≥?7 days) compared to those with myeloma. Mucositis above grade 3, diarrhoea and fever were more likely to occur in patients with prolonged neutropenia. Bacteraemia was documented in 12.6% of the patients. Total mortality rate was 3.7%, and that attributed to bacteraemia was 12.5% in the bacteraemia subgroup. Among bacterial isolates recovered from clinical specimens (89 isolates), 70% were Gram-negative, of which 57% were fluoroquinolone susceptible. Ninety-five percent of the Gram-negative bacteria causing bacteraemia were susceptible to fluoroquinolones.Conclusion
Bacterial pathogens causing bacteraemia were still highly susceptible to fluoroquinolones, despite the high prevalence of fluoroquinolone-resistant strains in the general bacterial ecology. Accordingly, the pertinence of fluoroquinolone prophylaxis in the AHSCT setting warrants further investigation. Moreover, continuous surveillance of local antibiograms in this patient population has become a must in an era of preponderant antibiotic resistance.40.
Nihal Fathi Samar H. Goma Nadia M. Ismail Abeer M. Ghandour Sally S. Youssef Nisreen A. Mohammed Eman Mosad 《The Egyptian Rheumatologist》2018,40(1):45-49