Comparison and correlation study of synovial ultrasound indices and serum VEGF in rheumatoid wrist arthritis before and after treatment

Clinical Rheumatology - Rheumatoid wrist arthritis is a chronic autoimmune disease, resulting in joint deformity and functional impairment. We aimed to compare the wrist synovial ultrasound indices...     

Sturge–Weber Syndrome Is Associated with Cortical Dysplasia ILAE Type IIIc and Excessive Hypertrophic Pyramidal Neurons in Brain Resections for Intractable Epilepsy

Sturge–Weber syndrome (SWS) is a rare syndrome characterized by capillary‐venous malformations involving skin and brain. Many patients with SWS also suffer from drug‐resistant epilepsy. We retrospectively studied a series of six SWS patients with epilepsy and extensive neurosurgical resections. At time of surgery, the patients' age ranged from 11 to 35 years (with a mean of 20.2 years). All surgical specimens were well preserved, which allowed a systematic microscopical inspection utilizing the 2011 ILAE classification for focal cortical dysplasia (FCD). Neuropathology revealed dysmorphic‐like neurons with hypertrophic cell bodies reminiscent to those described for FCD type IIa in all cases. However, gross architectural abnormalities of neocortical layering typical for FCD type IIa were missing, and we propose to classify this pattern as FCD ILAE type IIIc. In addition, our patients with earliest seizure onset also showed polymicrogyria (PMG; n = 4). The ictal onset zones were identified in all patients by subdural electrodes, and these areas always showed histopathological evidence for FCD type IIIc. Four out of five patients had favorable seizure control after surgery with a mean follow‐up period of 1.7 years. We concluded from our study that FCD type IIIc and PMG are frequently associated findings in SWS. FCD type IIIc may play a major epileptogenic role in SWS and complete resection of the associated FCD should be considered a prognostic key factor to achieve seizure control.     

Anisotropic tough poly(vinyl alcohol)/graphene oxide nanocomposite hydrogels for potential biomedical applications

Hydrogels, one of the most important bioinspired materials, are receiving increasing attention because of their potential applications as scaffolds for artificial tissue engineering and vehicles for drug delivery, etc. However, these applications are always severely limited by their microstructure and mechanical behavior. Here we report the fabrication of a tough polyvinyl alcohol/graphene oxide (PVA/GO) nanocomposite hydrogel through a simple and effective directional freezing–thawing (DFT) technique. The resulting hydrogels show well-developed anisotropic microstructure and excellent mechanical properties with the assistance of DFT method and lamellar graphene. The hydrogels with anisotropic porous structures that consisted of micro-sized fibers and lamellas exhibit high tensile strengths, up to 1.85 MPa with a water content of 90%. More interestingly, the PVA/GO composite hydrogels exhibit the better thermostability, which can maintain the original shape when swollen in hot water (65 °C). In addition, the hydrogels with biocompatibility show good drug release efficiency due to the unique hierarchical structure. The successful synthesis of such hydrogel materials might pave the way to explore applications in biomedical and soft robotics fields.

Tough PVA/GO nanocomposite hydrogel with well-developed anisotropic microstructure and excellent mechanical properties.     

The history of interventional therapy for liver cancer in China

In China interventional therapy of liver cancer started in the 1980s. It is well-known that Professor Lin Gui is the founding father of Interventional radiology. Under the leadership of Lin Gui and other professors, interventional therapy of liver cancer has swiftly progressed in China. Indeed, TAI, TAE, TACE and ablation therapy have witnessed great innovations in hardware facilities, technical means, and therapeutic philosophy, while incorporating Chinese characteristics. As with the development of combined interventional therapy in China, interventional treatment of liver cancer has gradually started the process of precision and individualization. Actually, multidisciplinary, multimodal, and polymorphic treatments will be the most suitable pattern for liver cancer in the future, among which combination of interventional therapy with targeted, immunological treatments and information technology (IT) tools may bring a revolutionary breakthrough in liver cancer treatment.     

高校女教师情绪智力与教学效能感的关系研究

目的:了解高校女教师情绪智力与教学效能感之间的关系,为高校女教师教学效能感及能力的提高提供科学依据。方法 :采用情绪智力量表(EIS)和教学效能感量表(UTES),对整群随机抽取的成都中医药大学88名在职女教师进行问卷调查。结果 :高校女教师教龄组各年龄段在情绪智力的差异有统计学意义。情绪智力总分与教学效能感总分、个人教学效能感和专业教学效能感有显著正相关,其中个人教学效能感与情绪感知、他人情绪管理有显著正相关;专业教学效能感与情绪感知、他人情绪管理和情绪表达有显著正相关。他人情绪管理这个维度进入教学效能感的回归方程,情绪智力主要通过理解他人情绪这个维度对教师教学效能感进行影响。结论 :情绪感知及他人情绪管理是高校女教师教学效能感的重要预测指标。     

Combining early post-resuscitation EEG and HRV features improves the prognostic performance in cardiac arrest model of rats

Objective

Early and reliable prediction of neurological outcome remains a challenge for comatose survivors of cardiac arrest (CA). The purpose of this study was to evaluate the predictive ability of EEG, heart rate variability (HRV) features and the combination of them for outcome prognostication in CA model of rats.

前部缺血性视神经病变的不典型荧光素眼底血管造影表现

目的探讨前部缺血性视神经病变(AION)患者的非典型荧光素眼底血管造影(FFA)表现。方法回顾性分析45例(52只眼)经临床确诊为AION患者的临床检查过程,比较分析其不典型的FFA表现等。结果45例(52只眼)呈典型AION表现者23例(25只眼),不典型表现者22例(27只眼)。不典型AION患者FFA表现为造影早中晚期均呈视乳头持续弱荧光等不典型表现。结论前部缺血性视神经病变有多种FFA表现。     

不同角膜屈光手术对基底膜下神经的影响

目的：观察角膜屈光不同术式后基底膜下神经恢复情况。
　　方法：角膜激光共焦显微镜观察术后1 mo 的 LASEK 12眼、LASIK 12眼、FLEx 12眼、SMILE 12眼,并对部分其它术后时段进行了对比观察。
　　结果：术后1 mo SMILE组基底膜下神经均未见明显破坏,走行规律,完整,切口处被切断神经对合良好;LASEK, LASIK和FLEx基底膜下神经仍现不同程度损害,其它时段眼显示随着时间推移,逐渐形成交通支。
　　结论：SMILE手术对基底膜下神经影响小,相对于其他几种角膜屈光手术,在术后神经恢复方面可能有一定优势。     

A novel method to prepare tussah/Bombyx mori silk fibroin-based films

The possibility of using silk fibroin in biomaterials for tissue engineering is a subject of broad interest. In this study, Bombyx mori/tussah silk fibroin (BSF/TSF) blend films were prepared by solution casting using CaCl₂/formic acid as a co-solvent and water as a rinse solvent. The morphology, crystallinity, thermal resistance, mechanical properties and water contact angle of the blend films as well as the biocompatibility were investigated. The BSF/TSF blend films displayed a smooth surface and specific nanostructure in their cross-section, originating from the nanofibril-preservation during fibroin dissolution. The water rinse process induced the formation of a stable β-sheet structure. The BSF film showed superior mechanical properties to the TSF film, and the blending with TSF led to a significant reduction in the strength and elasticity of blend films. However, adding the TSF component could regulate the hydrophilic properties and enhance cell growth on the blend films. The BSF/TSF blend films with specific nanostructure, stable secondary structure, appropriate mechanical properties, and good biocompatibility, are promising candidates for application in regenerative medicine.

A novel method is reported to prepare tussah/Bombyx mori silk fibroin blend films featured transparent, flexible and biocompatible.     

西安某高校研究生夜磨牙症现状调查

目的了解高校研究生夜磨牙症的发生情况及相关影响因素。方法选取西安交通大学2014年参加体检的1 944名研究生进行问卷调查和口腔检查,对检查结果进行统计学分析。结果高校研究生夜磨牙症发病率为14.0%;男生发病率为13.9%,女生发病率为14.2%,女生略高于男生,但差异无统计学意义。41.0%的被调查者称有室友患夜磨牙症,其中73.7%的人认为会影响晚上休息。熬夜、精神紧张、父母磨牙、颞颌关节紊乱为夜磨牙症的危险因素(P0.01)。结论高校研究生夜磨牙症发生率较高,对自身健康和同住人员均有影响,但就诊率较低。故学校应加强健康教育,预防和减少学生人群夜磨牙症的发生。