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Yuriko Masuda Yasunori Nawa Wataru Inami Yoshimasa Kawata 《Biomedical optics express》2015,6(8):3128-3133
Intracellular structures of HeLa cells are observed using a direct electron beam excitation-assisted fluorescence (D-EXA) microscope. In this microscope, a silicon nitride membrane is used as a culture plate, which typically has a low biocompatibility between the sample and the silicon nitride surface to prevent the HeLa cells from adhering strongly to the surface. In this work, the surface of silicon nitride is modified to allow strong cell attachment, which enables high-resolution observation of intracellular structures and an increased signal-to-noise ratio. In addition, the penetration depth of the electron beam is evaluated using Monte Carlo simulations. We can conclude from the results of the observations and simulations that the surface modification technique is promising for the observation of intracellular structures using the D-EXA microscope.OCIS codes: (170.0170) Medical optics and biotechnology, (170.0180) Microscopy 相似文献
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Oku T Maeda M Waga E Wada Y Nagamachi Y Fujita M Suzuki Y Nagashima K Niitsu Y 《Journal of gastroenterology》2005,40(10):987-992
Cholangitis and pancreatitis associated with cytomegalovirus (CMV) infection in an immunocompetent patient is reported. Endoscopic
retrograde cholangiography performed on a 55-year-old man for evaluation of the cause of jaundice and liver dysfunction revealed
a distal focal irregular narrowing of the common bile duct. Microscopic findings of the resected specimen showed chronic cholangitis
and CMV pancreatitis. Immunohistochemistry disclosed that epithelial cells in the inflamed bile duct were positive for CMV
antigen, which was compatible with CMV cholangitis. Inflammation of the biliary tract or pancreas by CMV has been commonly
reported as a complication in immunocompromised patients. Our report appears to be a rare case, but suggests that CMV cholangitis
or pancreatitis should be considered in the differential diagnoses of common bile duct stenosis or pancreatitis even in immunocompetent
individuals. 相似文献
77.
Mikami M Sadahira Y Suetsugu Y Wada H Sugihara T 《International journal of hematology》2004,80(4):365-369
We report a case of a very rare disorder, histiocytic sarcoma, from a review of our autopsy cases. The neoplastic cells that
proliferated in organs throughout the body were large cells containing eosinophilic cytoplasm and pleomorphic nuclei with
prominent nucleoli. In the bone marrow, erythrophagocytosis by neoplastic cells was observed. The neoplastic cells were positive
not only for lysozymes and CD68 (KP-1, PG-M1, and Ki-M1P) but also for a monocyte/macrophage-specific marker, CD163. In contrast,
the results of tests for markers of myeloid cells, lymphoid cells, and epithelial cells were all negative. In a polymerase
chain reaction study of paraffin-embedded tissues, analyses for the rearrangement of immunoglobulin heavy chain and T-cell
receptor-γ genes were negative. The current World Health Organization diagnostic criteria for histiocytic sarcoma regard immunohistochemical
investigation as crucial. In this regard, the highly specific positivity for CD163 in this patient indicates that immunohistochemical
staining of CD163 is very useful for the diagnosis of histiocytic sarcoma. 相似文献
78.
Isolated ACTH deficiency with Graves' disease: a case report 总被引:1,自引:0,他引:1
A 60-year-old man was hospitalized with complaints of general malaise and weight loss. On admission, ACTH and cortisol levels were low, and thyroid function tests revealed hyperthyroidism. These findings and further examination led to a diagnosis of isolated ACTH deficiency (IAD) with Graves' disease. It is known that IAD is frequently associated with thyroid disease, but its association with Graves' disease is rare. The present case is worth noting, because some reports indicate that aggravation of associated Graves' disease may concomitantly aggravate adrenal insufficiency in patients with IAD. 相似文献
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Ryosuke Sakemi Suketo So Yosuke Morimitsu Hajime Imada Hiroshi Ishihara Kenjiro Kuhara Yuichiro Oku Hiroya Terabe Masahiro Kishi Ei Sasaki Miyuki Sakemi Masayuki Shimokobe 《Clinical journal of gastroenterology》2014,7(4):310-315
Primary squamous cell carcinoma is rarely observed, with a reported incidence of 0.04–0.07 % of all gastric cancers. An 81-year-old male underwent chemoradiotherapy for type 1 gastric cancer of the posterior wall of the cardiac region in 2005. The tumor disappeared after 1 year of therapy, following which an area of white epithelium, approximately 30 mm in diameter and continuous with the esophageal mucosa, became visible. Biopsy of the white epithelium indicated normal squamous epithelium. An elevated lesion was subsequently detected in the area of white epithelium on upper gastrointestinal endoscopy during a follow-up examination 5 years after therapy. As a biopsy of the same site indicated squamous cell carcinoma, we performed endoscopic submucosal dissection. Histopathological examination indicated high-grade fibrosis due to radiotherapy and showed a moderately differentiated squamous cell carcinoma invading the scarred portion. We describe a case where the developmental process of a squamous cell carcinoma was observed using endoscopy, including narrow band imaging with magnification. This carcinoma likely originated from squamous metaplasia that developed after chemoradiotherapy was administered for a gastric cancer. 相似文献